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Gene: C12orf56 |
Gene summary for C12ORF56 |
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Gene information | Species | Human | Gene symbol | C12orf56 | Gene ID | 115749 |
Gene name | chromosome 12 open reading frame 56 | |
Gene Alias | C12orf56 | |
Cytomap | 12q14.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q8IXR9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115749 | C12orf56 | LZE24T | Human | Esophagus | ESCC | 9.53e-03 | 1.46e-01 | 0.0596 |
115749 | C12orf56 | P2T-E | Human | Esophagus | ESCC | 2.63e-06 | 1.35e-01 | 0.1177 |
115749 | C12orf56 | P4T-E | Human | Esophagus | ESCC | 1.93e-08 | 1.84e-01 | 0.1323 |
115749 | C12orf56 | P5T-E | Human | Esophagus | ESCC | 6.86e-04 | 1.05e-01 | 0.1327 |
115749 | C12orf56 | P8T-E | Human | Esophagus | ESCC | 5.67e-25 | 4.25e-01 | 0.0889 |
115749 | C12orf56 | P10T-E | Human | Esophagus | ESCC | 4.33e-19 | 3.50e-01 | 0.116 |
115749 | C12orf56 | P12T-E | Human | Esophagus | ESCC | 1.01e-23 | 4.28e-01 | 0.1122 |
115749 | C12orf56 | P15T-E | Human | Esophagus | ESCC | 2.25e-22 | 5.29e-01 | 0.1149 |
115749 | C12orf56 | P16T-E | Human | Esophagus | ESCC | 8.53e-08 | 9.56e-02 | 0.1153 |
115749 | C12orf56 | P20T-E | Human | Esophagus | ESCC | 1.16e-14 | 3.15e-01 | 0.1124 |
115749 | C12orf56 | P21T-E | Human | Esophagus | ESCC | 4.39e-06 | 1.46e-01 | 0.1617 |
115749 | C12orf56 | P22T-E | Human | Esophagus | ESCC | 5.00e-08 | 1.13e-01 | 0.1236 |
115749 | C12orf56 | P23T-E | Human | Esophagus | ESCC | 6.88e-13 | 3.75e-01 | 0.108 |
115749 | C12orf56 | P26T-E | Human | Esophagus | ESCC | 1.60e-08 | 1.07e-01 | 0.1276 |
115749 | C12orf56 | P27T-E | Human | Esophagus | ESCC | 9.30e-25 | 5.01e-01 | 0.1055 |
115749 | C12orf56 | P28T-E | Human | Esophagus | ESCC | 1.81e-07 | 1.81e-01 | 0.1149 |
115749 | C12orf56 | P30T-E | Human | Esophagus | ESCC | 1.10e-07 | 3.36e-01 | 0.137 |
115749 | C12orf56 | P31T-E | Human | Esophagus | ESCC | 4.61e-07 | 7.96e-02 | 0.1251 |
115749 | C12orf56 | P32T-E | Human | Esophagus | ESCC | 1.94e-08 | 1.60e-01 | 0.1666 |
115749 | C12orf56 | P36T-E | Human | Esophagus | ESCC | 1.12e-05 | 2.97e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C12orf56 | SNV | Missense_Mutation | novel | c.734N>A | p.Gly245Glu | p.G245E | Q8IXR9 | protein_coding | tolerated(0.1) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C12orf56 | SNV | Missense_Mutation | c.1642N>G | p.Gln548Glu | p.Q548E | Q8IXR9 | protein_coding | tolerated(0.38) | benign(0.215) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C12orf56 | SNV | Missense_Mutation | novel | c.740G>C | p.Gly247Ala | p.G247A | Q8IXR9 | protein_coding | tolerated(0.11) | probably_damaging(0.992) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C12orf56 | SNV | Missense_Mutation | novel | c.1067A>C | p.Lys356Thr | p.K356T | Q8IXR9 | protein_coding | deleterious(0.01) | possibly_damaging(0.644) | TCGA-VS-A8QH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD |
C12orf56 | SNV | Missense_Mutation | novel | c.1262G>A | p.Arg421Lys | p.R421K | Q8IXR9 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C12orf56 | SNV | Missense_Mutation | novel | c.336N>T | p.Leu112Phe | p.L112F | Q8IXR9 | protein_coding | tolerated(0.24) | probably_damaging(0.998) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C12orf56 | SNV | Missense_Mutation | novel | c.1739N>T | p.Arg580Met | p.R580M | Q8IXR9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C12orf56 | SNV | Missense_Mutation | c.1541N>A | p.Ala514Asp | p.A514D | Q8IXR9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
C12orf56 | SNV | Missense_Mutation | c.398A>C | p.Lys133Thr | p.K133T | Q8IXR9 | protein_coding | tolerated(0.51) | benign(0.051) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
C12orf56 | deletion | Frame_Shift_Del | c.1657delN | p.Cys553AlafsTer23 | p.C553Afs*23 | Q8IXR9 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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