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Gene: C10orf11 |
Gene summary for C10ORF11 |
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Gene information | Species | Human | Gene symbol | C10orf11 | Gene ID | 83938 |
Gene name | leucine rich melanocyte differentiation associated | |
Gene Alias | C10orf11 | |
Cytomap | 10q22.2-q22.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A087WWI0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83938 | C10orf11 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.72e-65 | 1.10e+00 | 0.294 |
83938 | C10orf11 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.89e-03 | 4.33e-01 | 0.3487 |
83938 | C10orf11 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.35e-15 | 5.55e-01 | 0.281 |
83938 | C10orf11 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.15e-20 | 4.46e-01 | 0.3859 |
83938 | C10orf11 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.94e-18 | 6.60e-01 | 0.2585 |
83938 | C10orf11 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.76e-28 | 5.42e-01 | 0.3005 |
83938 | C10orf11 | AEH-subject2 | Human | Endometrium | AEH | 2.75e-02 | -9.93e-02 | -0.2525 |
83938 | C10orf11 | EEC-subject1 | Human | Endometrium | EEC | 3.51e-03 | -9.93e-02 | -0.2682 |
83938 | C10orf11 | EEC-subject2 | Human | Endometrium | EEC | 3.29e-02 | -9.93e-02 | -0.2607 |
83938 | C10orf11 | EEC-subject3 | Human | Endometrium | EEC | 3.71e-04 | -9.93e-02 | -0.2525 |
83938 | C10orf11 | EEC-subject4 | Human | Endometrium | EEC | 3.51e-03 | -9.93e-02 | -0.2571 |
83938 | C10orf11 | EEC-subject5 | Human | Endometrium | EEC | 1.56e-02 | -9.93e-02 | -0.249 |
83938 | C10orf11 | GSM5276934 | Human | Endometrium | EEC | 3.29e-02 | -9.93e-02 | -0.0913 |
83938 | C10orf11 | GSM5276935 | Human | Endometrium | EEC | 1.56e-02 | -9.93e-02 | -0.123 |
83938 | C10orf11 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.56e-02 | -9.93e-02 | -0.1934 |
83938 | C10orf11 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 8.54e-03 | -9.93e-02 | -0.1916 |
83938 | C10orf11 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 7.40e-03 | -9.93e-02 | -0.1269 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C10orf11 | SNV | Missense_Mutation | novel | c.268N>G | p.Leu90Val | p.L90V | protein_coding | tolerated(0.07) | benign(0.377) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C10orf11 | SNV | Missense_Mutation | novel | c.110A>C | p.Asp37Ala | p.D37A | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
C10orf11 | SNV | Missense_Mutation | novel | c.586C>A | p.Leu196Ile | p.L196I | protein_coding | tolerated(0.2) | benign(0.108) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
C10orf11 | SNV | Missense_Mutation | rs567691214 | c.625G>A | p.Val209Ile | p.V209I | protein_coding | tolerated(0.5) | benign(0.015) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
C10orf11 | SNV | Missense_Mutation | novel | c.626T>C | p.Val209Ala | p.V209A | protein_coding | tolerated(0.56) | benign(0.22) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
C10orf11 | SNV | Missense_Mutation | novel | c.403T>G | p.Phe135Val | p.F135V | protein_coding | deleterious(0.01) | possibly_damaging(0.84) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C10orf11 | SNV | Missense_Mutation | c.158N>A | p.Arg53Lys | p.R53K | protein_coding | tolerated(0.92) | benign(0) | TCGA-G3-A7M9-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
C10orf11 | SNV | Missense_Mutation | c.602G>T | p.Gly201Val | p.G201V | protein_coding | deleterious(0.03) | possibly_damaging(0.847) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C10orf11 | SNV | Missense_Mutation | c.366N>C | p.Leu122Phe | p.L122F | protein_coding | tolerated(0.32) | benign(0.087) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C10orf11 | SNV | Missense_Mutation | novel | c.341C>T | p.Ala114Val | p.A114V | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-77-8128-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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