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Gene: BTBD7 |
Gene summary for BTBD7 |
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Gene information | Species | Human | Gene symbol | BTBD7 | Gene ID | 55727 |
Gene name | BTB domain containing 7 | |
Gene Alias | FUP1 | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0001763 | UniProtAcc | Q9P203 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55727 | BTBD7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.42e-07 | -4.47e-01 | 0.0155 |
55727 | BTBD7 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.67e-02 | 3.62e-01 | -0.1954 |
55727 | BTBD7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.17e-03 | -3.33e-01 | 0.294 |
55727 | BTBD7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.95e-11 | -4.82e-01 | 0.3859 |
55727 | BTBD7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.49e-13 | -5.65e-01 | 0.3005 |
55727 | BTBD7 | F007 | Human | Colorectum | FAP | 2.31e-02 | -3.29e-01 | 0.1176 |
55727 | BTBD7 | A001-C-207 | Human | Colorectum | FAP | 5.04e-06 | -3.96e-01 | 0.1278 |
55727 | BTBD7 | A015-C-203 | Human | Colorectum | FAP | 1.44e-35 | -6.07e-01 | -0.1294 |
55727 | BTBD7 | A015-C-204 | Human | Colorectum | FAP | 5.88e-09 | -4.13e-01 | -0.0228 |
55727 | BTBD7 | A014-C-040 | Human | Colorectum | FAP | 8.76e-05 | -4.79e-01 | -0.1184 |
55727 | BTBD7 | A002-C-201 | Human | Colorectum | FAP | 5.13e-18 | -4.19e-01 | 0.0324 |
55727 | BTBD7 | A002-C-203 | Human | Colorectum | FAP | 9.05e-08 | -2.94e-01 | 0.2786 |
55727 | BTBD7 | A001-C-119 | Human | Colorectum | FAP | 5.83e-11 | -5.70e-01 | -0.1557 |
55727 | BTBD7 | A001-C-108 | Human | Colorectum | FAP | 1.56e-18 | -4.12e-01 | -0.0272 |
55727 | BTBD7 | A002-C-205 | Human | Colorectum | FAP | 4.47e-28 | -6.23e-01 | -0.1236 |
55727 | BTBD7 | A001-C-104 | Human | Colorectum | FAP | 3.26e-04 | -3.94e-01 | 0.0184 |
55727 | BTBD7 | A015-C-005 | Human | Colorectum | FAP | 2.07e-06 | -3.64e-01 | -0.0336 |
55727 | BTBD7 | A015-C-006 | Human | Colorectum | FAP | 7.53e-20 | -6.28e-01 | -0.0994 |
55727 | BTBD7 | A015-C-106 | Human | Colorectum | FAP | 2.73e-21 | -4.70e-01 | -0.0511 |
55727 | BTBD7 | A002-C-114 | Human | Colorectum | FAP | 9.60e-23 | -6.11e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0022612 | Colorectum | AD | gland morphogenesis | 42/3918 | 118/18723 | 1.62e-04 | 2.23e-03 | 42 |
GO:0001763 | Colorectum | AD | morphogenesis of a branching structure | 56/3918 | 196/18723 | 6.60e-03 | 4.09e-02 | 56 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00226122 | Colorectum | MSS | gland morphogenesis | 41/3467 | 118/18723 | 2.02e-05 | 4.30e-04 | 41 |
GO:00017631 | Colorectum | MSS | morphogenesis of a branching structure | 55/3467 | 196/18723 | 6.70e-04 | 7.25e-03 | 55 |
GO:0061138 | Colorectum | MSS | morphogenesis of a branching epithelium | 51/3467 | 182/18723 | 1.06e-03 | 1.05e-02 | 51 |
GO:00487324 | Colorectum | FAP | gland development | 103/2622 | 436/18723 | 3.61e-08 | 3.12e-06 | 103 |
GO:00226123 | Colorectum | FAP | gland morphogenesis | 34/2622 | 118/18723 | 2.13e-05 | 5.12e-04 | 34 |
GO:00017632 | Colorectum | FAP | morphogenesis of a branching structure | 44/2622 | 196/18723 | 8.79e-04 | 9.01e-03 | 44 |
GO:0060688 | Colorectum | FAP | regulation of morphogenesis of a branching structure | 15/2622 | 50/18723 | 2.68e-03 | 2.08e-02 | 15 |
GO:00611381 | Colorectum | FAP | morphogenesis of a branching epithelium | 39/2622 | 182/18723 | 3.98e-03 | 2.76e-02 | 39 |
GO:00487325 | Colorectum | CRC | gland development | 88/2078 | 436/18723 | 1.62e-08 | 2.79e-06 | 88 |
GO:00226124 | Colorectum | CRC | gland morphogenesis | 29/2078 | 118/18723 | 2.74e-05 | 7.49e-04 | 29 |
GO:00606881 | Colorectum | CRC | regulation of morphogenesis of a branching structure | 14/2078 | 50/18723 | 8.08e-04 | 1.02e-02 | 14 |
GO:00017633 | Colorectum | CRC | morphogenesis of a branching structure | 36/2078 | 196/18723 | 1.64e-03 | 1.70e-02 | 36 |
GO:2000027 | Colorectum | CRC | regulation of animal organ morphogenesis | 24/2078 | 125/18723 | 5.12e-03 | 3.92e-02 | 24 |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTBD7 | SNV | Missense_Mutation | c.921N>C | p.Leu307Phe | p.L307F | Q9P203 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
BTBD7 | SNV | Missense_Mutation | c.2830N>T | p.Asp944Tyr | p.D944Y | Q9P203 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BTBD7 | SNV | Missense_Mutation | c.3194C>T | p.Thr1065Ile | p.T1065I | Q9P203 | protein_coding | tolerated_low_confidence(0.09) | probably_damaging(0.991) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BTBD7 | SNV | Missense_Mutation | rs546190692 | c.1784N>T | p.Thr595Met | p.T595M | Q9P203 | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-AA-3692-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | PD |
BTBD7 | SNV | Missense_Mutation | novel | c.1648C>A | p.Leu550Ile | p.L550I | Q9P203 | protein_coding | tolerated(0.27) | benign(0.19) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BTBD7 | SNV | Missense_Mutation | rs780909487 | c.1307N>T | p.Ser436Leu | p.S436L | Q9P203 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTBD7 | SNV | Missense_Mutation | rs780909487 | c.1307N>T | p.Ser436Leu | p.S436L | Q9P203 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
BTBD7 | SNV | Missense_Mutation | c.3292G>A | p.Gly1098Ser | p.G1098S | Q9P203 | protein_coding | deleterious_low_confidence(0.03) | benign(0.007) | TCGA-CA-5256-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
BTBD7 | SNV | Missense_Mutation | c.638G>T | p.Arg213Met | p.R213M | Q9P203 | protein_coding | deleterious(0.03) | possibly_damaging(0.866) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BTBD7 | SNV | Missense_Mutation | rs61747488 | c.1075G>T | p.Ala359Ser | p.A359S | Q9P203 | protein_coding | tolerated(0.65) | benign(0.071) | TCGA-CM-6675-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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