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Gene: BRI3BP |
Gene summary for BRI3BP |
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Gene information | Species | Human | Gene symbol | BRI3BP | Gene ID | 140707 |
Gene name | BRI3 binding protein | |
Gene Alias | BNAS1 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8WY22 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140707 | BRI3BP | HTA11_347_2000001011 | Human | Colorectum | AD | 1.36e-11 | 5.56e-01 | -0.1954 |
140707 | BRI3BP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.63e-02 | 2.85e-01 | 0.3859 |
140707 | BRI3BP | A015-C-203 | Human | Colorectum | FAP | 1.50e-04 | -1.67e-01 | -0.1294 |
140707 | BRI3BP | A002-C-205 | Human | Colorectum | FAP | 6.36e-04 | -1.14e-01 | -0.1236 |
140707 | BRI3BP | A002-C-114 | Human | Colorectum | FAP | 1.29e-02 | -1.51e-01 | -0.1561 |
140707 | BRI3BP | A015-C-104 | Human | Colorectum | FAP | 2.00e-04 | -1.45e-01 | -0.1899 |
140707 | BRI3BP | A002-C-016 | Human | Colorectum | FAP | 2.29e-02 | -1.62e-01 | 0.0521 |
140707 | BRI3BP | A015-C-002 | Human | Colorectum | FAP | 1.57e-02 | -2.41e-01 | -0.0763 |
140707 | BRI3BP | A002-C-116 | Human | Colorectum | FAP | 2.04e-03 | -1.33e-01 | -0.0452 |
140707 | BRI3BP | A018-E-020 | Human | Colorectum | FAP | 5.57e-05 | -2.16e-01 | -0.2034 |
140707 | BRI3BP | LZE7T | Human | Esophagus | ESCC | 2.20e-05 | 2.37e-01 | 0.0667 |
140707 | BRI3BP | P2T-E | Human | Esophagus | ESCC | 9.79e-42 | 8.82e-01 | 0.1177 |
140707 | BRI3BP | P4T-E | Human | Esophagus | ESCC | 8.53e-28 | 8.57e-01 | 0.1323 |
140707 | BRI3BP | P5T-E | Human | Esophagus | ESCC | 7.12e-25 | 5.70e-01 | 0.1327 |
140707 | BRI3BP | P8T-E | Human | Esophagus | ESCC | 4.45e-06 | 2.41e-01 | 0.0889 |
140707 | BRI3BP | P9T-E | Human | Esophagus | ESCC | 1.02e-06 | 9.87e-02 | 0.1131 |
140707 | BRI3BP | P10T-E | Human | Esophagus | ESCC | 9.59e-04 | 1.21e-01 | 0.116 |
140707 | BRI3BP | P11T-E | Human | Esophagus | ESCC | 1.37e-11 | 3.06e-01 | 0.1426 |
140707 | BRI3BP | P12T-E | Human | Esophagus | ESCC | 3.09e-04 | 1.20e-01 | 0.1122 |
140707 | BRI3BP | P15T-E | Human | Esophagus | ESCC | 3.47e-06 | 1.79e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRI3BP | SNV | Missense_Mutation | rs201462094 | c.511N>A | p.Val171Met | p.V171M | Q8WY22 | protein_coding | tolerated(0.18) | benign(0.052) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
BRI3BP | SNV | Missense_Mutation | c.655N>T | p.Ser219Cys | p.S219C | Q8WY22 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.639) | TCGA-33-4586-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
BRI3BP | SNV | Missense_Mutation | novel | c.407A>T | p.Tyr136Phe | p.Y136F | Q8WY22 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
BRI3BP | SNV | Missense_Mutation | c.248N>T | p.Gly83Val | p.G83V | Q8WY22 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-39-5016-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BRI3BP | SNV | Missense_Mutation | rs769412405 | c.389N>C | p.Gly130Ala | p.G130A | Q8WY22 | protein_coding | tolerated(0.25) | benign(0.181) | TCGA-43-2578-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BRI3BP | SNV | Missense_Mutation | novel | c.209A>G | p.Gln70Arg | p.Q70R | Q8WY22 | protein_coding | tolerated(0.32) | benign(0.402) | TCGA-77-8153-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BRI3BP | SNV | Missense_Mutation | rs145269757 | c.490G>A | p.Val164Ile | p.V164I | Q8WY22 | protein_coding | tolerated(0.93) | benign(0.003) | TCGA-M7-A71Z-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
BRI3BP | SNV | Missense_Mutation | c.509G>A | p.Cys170Tyr | p.C170Y | Q8WY22 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BRI3BP | SNV | Missense_Mutation | c.710G>A | p.Arg237His | p.R237H | Q8WY22 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.982) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
BRI3BP | SNV | Missense_Mutation | rs769016056 | c.289G>A | p.Glu97Lys | p.E97K | Q8WY22 | protein_coding | deleterious(0.04) | benign(0.177) | TCGA-VQ-A91S-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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