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Gene: BCS1L |
Gene summary for BCS1L |
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Gene information | Species | Human | Gene symbol | BCS1L | Gene ID | 617 |
Gene name | BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone | |
Gene Alias | BCS | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R467 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
617 | BCS1L | LZE4T | Human | Esophagus | ESCC | 2.55e-10 | 2.33e-01 | 0.0811 |
617 | BCS1L | LZE24T | Human | Esophagus | ESCC | 2.90e-10 | 1.76e-01 | 0.0596 |
617 | BCS1L | P2T-E | Human | Esophagus | ESCC | 8.46e-14 | 2.37e-01 | 0.1177 |
617 | BCS1L | P4T-E | Human | Esophagus | ESCC | 2.81e-08 | 1.98e-01 | 0.1323 |
617 | BCS1L | P5T-E | Human | Esophagus | ESCC | 1.30e-13 | 3.36e-01 | 0.1327 |
617 | BCS1L | P8T-E | Human | Esophagus | ESCC | 3.14e-15 | 1.99e-01 | 0.0889 |
617 | BCS1L | P9T-E | Human | Esophagus | ESCC | 4.95e-09 | 1.84e-01 | 0.1131 |
617 | BCS1L | P10T-E | Human | Esophagus | ESCC | 2.55e-11 | 1.84e-01 | 0.116 |
617 | BCS1L | P11T-E | Human | Esophagus | ESCC | 1.58e-09 | 3.20e-01 | 0.1426 |
617 | BCS1L | P12T-E | Human | Esophagus | ESCC | 3.06e-12 | 2.07e-01 | 0.1122 |
617 | BCS1L | P15T-E | Human | Esophagus | ESCC | 1.76e-16 | 3.20e-01 | 0.1149 |
617 | BCS1L | P16T-E | Human | Esophagus | ESCC | 1.10e-14 | 3.16e-01 | 0.1153 |
617 | BCS1L | P17T-E | Human | Esophagus | ESCC | 3.41e-07 | 3.31e-01 | 0.1278 |
617 | BCS1L | P19T-E | Human | Esophagus | ESCC | 1.25e-05 | 4.07e-01 | 0.1662 |
617 | BCS1L | P20T-E | Human | Esophagus | ESCC | 5.38e-20 | 3.92e-01 | 0.1124 |
617 | BCS1L | P21T-E | Human | Esophagus | ESCC | 4.16e-26 | 4.91e-01 | 0.1617 |
617 | BCS1L | P22T-E | Human | Esophagus | ESCC | 1.53e-16 | 2.20e-01 | 0.1236 |
617 | BCS1L | P23T-E | Human | Esophagus | ESCC | 2.04e-16 | 2.80e-01 | 0.108 |
617 | BCS1L | P24T-E | Human | Esophagus | ESCC | 5.21e-19 | 3.96e-01 | 0.1287 |
617 | BCS1L | P26T-E | Human | Esophagus | ESCC | 2.65e-07 | 1.61e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:0072655110 | Esophagus | ESCC | establishment of protein localization to mitochondrion | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:0070585110 | Esophagus | ESCC | protein localization to mitochondrion | 100/8552 | 125/18723 | 2.96e-15 | 1.77e-13 | 100 |
GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
GO:0010257110 | Esophagus | ESCC | NADH dehydrogenase complex assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:0032981110 | Esophagus | ESCC | mitochondrial respiratory chain complex I assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:001700413 | Esophagus | ESCC | cytochrome complex assembly | 34/8552 | 36/18723 | 5.08e-10 | 1.31e-08 | 34 |
GO:005120515 | Esophagus | ESCC | protein insertion into membrane | 46/8552 | 57/18723 | 5.90e-08 | 1.04e-06 | 46 |
GO:000853512 | Esophagus | ESCC | respiratory chain complex IV assembly | 24/8552 | 26/18723 | 6.87e-07 | 8.99e-06 | 24 |
GO:003361712 | Esophagus | ESCC | mitochondrial cytochrome c oxidase assembly | 21/8552 | 22/18723 | 8.75e-07 | 1.13e-05 | 21 |
GO:009015118 | Esophagus | ESCC | establishment of protein localization to mitochondrial membrane | 26/8552 | 30/18723 | 3.79e-06 | 4.12e-05 | 26 |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:007265512 | Liver | HCC | establishment of protein localization to mitochondrion | 98/7958 | 120/18723 | 1.18e-18 | 1.46e-16 | 98 |
GO:007058512 | Liver | HCC | protein localization to mitochondrion | 101/7958 | 125/18723 | 1.53e-18 | 1.86e-16 | 101 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCS1L | SNV | Missense_Mutation | c.937N>A | p.Leu313Ile | p.L313I | Q9Y276 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
BCS1L | SNV | Missense_Mutation | novel | c.614T>C | p.Val205Ala | p.V205A | Q9Y276 | protein_coding | deleterious(0) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BCS1L | SNV | Missense_Mutation | novel | c.758N>C | p.Leu253Pro | p.L253P | Q9Y276 | protein_coding | deleterious(0) | benign(0.081) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BCS1L | SNV | Missense_Mutation | rs747956412 | c.269N>A | p.Arg90His | p.R90H | Q9Y276 | protein_coding | tolerated(0.15) | benign(0.009) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BCS1L | insertion | Frame_Shift_Ins | novel | c.596_597insTT | p.Arg200SerfsTer56 | p.R200Sfs*56 | Q9Y276 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
BCS1L | SNV | Missense_Mutation | c.464N>A | p.Arg155Gln | p.R155Q | Q9Y276 | protein_coding | tolerated(0.14) | possibly_damaging(0.473) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BCS1L | SNV | Missense_Mutation | rs121908577 | c.548N>A | p.Arg183His | p.R183H | Q9Y276 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCS1L | SNV | Missense_Mutation | c.599N>A | p.Arg200Gln | p.R200Q | Q9Y276 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BCS1L | SNV | Missense_Mutation | rs144823158 | c.821N>T | p.Pro274Leu | p.P274L | Q9Y276 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BCS1L | SNV | Missense_Mutation | novel | c.113N>C | p.Leu38Pro | p.L38P | Q9Y276 | protein_coding | tolerated(0.2) | possibly_damaging(0.516) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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