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Gene: BCO2 |
Gene summary for BCO2 |
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Gene information | Species | Human | Gene symbol | BCO2 | Gene ID | 83875 |
Gene name | beta-carotene oxygenase 2 | |
Gene Alias | B-DIOX-II | |
Cytomap | 11q23.1 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | Q9BYV7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83875 | BCO2 | S43 | Human | Liver | Cirrhotic | 3.92e-18 | -5.37e-01 | -0.0187 |
83875 | BCO2 | HCC1_Meng | Human | Liver | HCC | 5.28e-23 | -5.99e-01 | 0.0246 |
83875 | BCO2 | HCC2_Meng | Human | Liver | HCC | 1.13e-18 | -5.54e-01 | 0.0107 |
83875 | BCO2 | cirrhotic1 | Human | Liver | Cirrhotic | 1.44e-05 | -6.67e-02 | 0.0202 |
83875 | BCO2 | cirrhotic2 | Human | Liver | Cirrhotic | 2.12e-08 | -4.34e-01 | 0.0201 |
83875 | BCO2 | cirrhotic3 | Human | Liver | Cirrhotic | 3.20e-06 | -2.08e-01 | 0.0215 |
83875 | BCO2 | p6 | Human | Liver | Cyst | 2.39e-03 | -6.05e-01 | -0.0218 |
83875 | BCO2 | HCC1 | Human | Liver | HCC | 5.62e-05 | -6.05e-01 | 0.5336 |
83875 | BCO2 | HCC2 | Human | Liver | HCC | 2.01e-07 | -6.05e-01 | 0.5341 |
83875 | BCO2 | HCC5 | Human | Liver | HCC | 3.00e-07 | -5.73e-01 | 0.4932 |
83875 | BCO2 | Pt13.a | Human | Liver | HCC | 3.02e-14 | -5.25e-01 | 0.021 |
83875 | BCO2 | Pt13.b | Human | Liver | HCC | 1.25e-10 | -5.39e-01 | 0.0251 |
83875 | BCO2 | Pt13.c | Human | Liver | HCC | 5.30e-09 | -5.66e-01 | 0.0076 |
83875 | BCO2 | Pt14.c | Human | Liver | HCC | 4.05e-02 | -5.70e-01 | 0.0054 |
83875 | BCO2 | Pt14.d | Human | Liver | HCC | 1.09e-16 | -5.75e-01 | 0.0143 |
83875 | BCO2 | S014 | Human | Liver | HCC | 5.42e-11 | -5.76e-01 | 0.2254 |
83875 | BCO2 | S015 | Human | Liver | HCC | 1.82e-08 | -5.84e-01 | 0.2375 |
83875 | BCO2 | S016 | Human | Liver | HCC | 2.37e-16 | -5.94e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200037712 | Liver | Cirrhotic | regulation of reactive oxygen species metabolic process | 67/4634 | 157/18723 | 6.07e-07 | 1.32e-05 | 67 |
GO:00725937 | Liver | Cirrhotic | reactive oxygen species metabolic process | 92/4634 | 239/18723 | 1.57e-06 | 3.03e-05 | 92 |
GO:004424212 | Liver | Cirrhotic | cellular lipid catabolic process | 82/4634 | 214/18723 | 6.91e-06 | 1.08e-04 | 82 |
GO:001604212 | Liver | Cirrhotic | lipid catabolic process | 112/4634 | 320/18723 | 2.31e-05 | 3.03e-04 | 112 |
GO:00060815 | Liver | Cirrhotic | cellular aldehyde metabolic process | 28/4634 | 60/18723 | 1.83e-04 | 1.71e-03 | 28 |
GO:00067202 | Liver | Cirrhotic | isoprenoid metabolic process | 46/4634 | 116/18723 | 2.71e-04 | 2.41e-03 | 46 |
GO:00067212 | Liver | Cirrhotic | terpenoid metabolic process | 38/4634 | 97/18723 | 1.16e-03 | 7.89e-03 | 38 |
GO:00518815 | Liver | Cirrhotic | regulation of mitochondrial membrane potential | 30/4634 | 74/18723 | 1.97e-03 | 1.23e-02 | 30 |
GO:004244511 | Liver | Cirrhotic | hormone metabolic process | 73/4634 | 218/18723 | 2.22e-03 | 1.36e-02 | 73 |
GO:012025411 | Liver | Cirrhotic | olefinic compound metabolic process | 51/4634 | 153/18723 | 1.03e-02 | 4.61e-02 | 51 |
GO:004424222 | Liver | HCC | cellular lipid catabolic process | 134/7958 | 214/18723 | 2.07e-09 | 5.79e-08 | 134 |
GO:001604221 | Liver | HCC | lipid catabolic process | 175/7958 | 320/18723 | 6.50e-06 | 7.88e-05 | 175 |
GO:200037722 | Liver | HCC | regulation of reactive oxygen species metabolic process | 92/7958 | 157/18723 | 3.34e-05 | 3.35e-04 | 92 |
GO:000608112 | Liver | HCC | cellular aldehyde metabolic process | 39/7958 | 60/18723 | 3.61e-04 | 2.50e-03 | 39 |
GO:005188112 | Liver | HCC | regulation of mitochondrial membrane potential | 45/7958 | 74/18723 | 1.13e-03 | 6.43e-03 | 45 |
GO:007259312 | Liver | HCC | reactive oxygen species metabolic process | 124/7958 | 239/18723 | 2.05e-03 | 1.04e-02 | 124 |
GO:000672011 | Liver | HCC | isoprenoid metabolic process | 65/7958 | 116/18723 | 2.23e-03 | 1.11e-02 | 65 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCO2 | SNV | Missense_Mutation | c.511N>A | p.Ala171Thr | p.A171T | Q9BYV7 | protein_coding | tolerated(0.58) | benign(0.38) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BCO2 | SNV | Missense_Mutation | c.808N>A | p.Val270Met | p.V270M | Q9BYV7 | protein_coding | deleterious(0.02) | possibly_damaging(0.897) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BCO2 | SNV | Missense_Mutation | c.416N>T | p.Arg139Leu | p.R139L | Q9BYV7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
BCO2 | SNV | Missense_Mutation | c.955T>C | p.Phe319Leu | p.F319L | Q9BYV7 | protein_coding | tolerated(0.27) | benign(0.02) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
BCO2 | SNV | Missense_Mutation | rs752219938 | c.1016N>A | p.Arg339His | p.R339H | Q9BYV7 | protein_coding | tolerated(1) | benign(0.001) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
BCO2 | insertion | Frame_Shift_Ins | novel | c.9dupT | p.Arg4SerfsTer75 | p.R4Sfs*75 | Q9BYV7 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BCO2 | SNV | Missense_Mutation | rs781512153 | c.1440N>A | p.Phe480Leu | p.F480L | Q9BYV7 | protein_coding | deleterious(0) | benign(0.378) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BCO2 | SNV | Missense_Mutation | novel | c.850N>C | p.Tyr284His | p.Y284H | Q9BYV7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCO2 | SNV | Missense_Mutation | novel | c.338N>T | p.Arg113Ile | p.R113I | Q9BYV7 | protein_coding | deleterious(0.04) | benign(0.435) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCO2 | SNV | Missense_Mutation | novel | c.778N>A | p.Asp260Asn | p.D260N | Q9BYV7 | protein_coding | tolerated(0.21) | benign(0.021) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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