![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: BCL7C |
Gene summary for BCL7C |
![]() |
Gene information | Species | Human | Gene symbol | BCL7C | Gene ID | 9274 |
Gene name | BAF chromatin remodeling complex subunit BCL7C | |
Gene Alias | SMARCJ3 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q8WUZ0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9274 | BCL7C | GSM4909281 | Human | Breast | IDC | 1.83e-25 | 6.44e-01 | 0.21 |
9274 | BCL7C | GSM4909282 | Human | Breast | IDC | 2.30e-09 | 4.40e-01 | -0.0288 |
9274 | BCL7C | GSM4909286 | Human | Breast | IDC | 4.29e-23 | 4.96e-01 | 0.1081 |
9274 | BCL7C | GSM4909291 | Human | Breast | IDC | 6.47e-04 | 3.53e-01 | 0.1753 |
9274 | BCL7C | GSM4909295 | Human | Breast | IDC | 4.53e-08 | 4.79e-01 | 0.0898 |
9274 | BCL7C | GSM4909298 | Human | Breast | IDC | 1.43e-13 | 4.28e-01 | 0.1551 |
9274 | BCL7C | GSM4909306 | Human | Breast | IDC | 1.20e-16 | 5.43e-01 | 0.1564 |
9274 | BCL7C | GSM4909311 | Human | Breast | IDC | 1.10e-07 | -1.21e-01 | 0.1534 |
9274 | BCL7C | GSM4909317 | Human | Breast | IDC | 4.53e-06 | 2.72e-01 | 0.1355 |
9274 | BCL7C | GSM4909319 | Human | Breast | IDC | 2.23e-13 | 1.02e-01 | 0.1563 |
9274 | BCL7C | GSM4909321 | Human | Breast | IDC | 1.66e-03 | 1.76e-01 | 0.1559 |
9274 | BCL7C | DCIS2 | Human | Breast | DCIS | 8.57e-67 | 3.06e-01 | 0.0085 |
9274 | BCL7C | LZE20T | Human | Esophagus | ESCC | 6.34e-07 | 3.46e-01 | 0.0662 |
9274 | BCL7C | LZE22D1 | Human | Esophagus | HGIN | 4.27e-03 | 9.13e-02 | 0.0595 |
9274 | BCL7C | LZE22T | Human | Esophagus | ESCC | 2.01e-03 | 2.45e-01 | 0.068 |
9274 | BCL7C | LZE24T | Human | Esophagus | ESCC | 2.31e-12 | 5.13e-01 | 0.0596 |
9274 | BCL7C | LZE21T | Human | Esophagus | ESCC | 9.78e-03 | 3.79e-01 | 0.0655 |
9274 | BCL7C | P1T-E | Human | Esophagus | ESCC | 5.68e-13 | 6.60e-01 | 0.0875 |
9274 | BCL7C | P2T-E | Human | Esophagus | ESCC | 5.30e-48 | 9.27e-01 | 0.1177 |
9274 | BCL7C | P4T-E | Human | Esophagus | ESCC | 3.08e-35 | 8.16e-01 | 0.1323 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCL7C | SNV | Missense_Mutation | c.209N>A | p.Arg70His | p.R70H | Q8WUZ0 | protein_coding | tolerated(0.06) | probably_damaging(0.991) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | |
BCL7C | SNV | Missense_Mutation | c.475N>A | p.Glu159Lys | p.E159K | Q8WUZ0 | protein_coding | deleterious(0) | benign(0.197) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BCL7C | SNV | Missense_Mutation | novel | c.509C>T | p.Pro170Leu | p.P170L | Q8WUZ0 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
BCL7C | SNV | Missense_Mutation | c.475G>A | p.Glu159Lys | p.E159K | Q8WUZ0 | protein_coding | deleterious(0) | benign(0.197) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
BCL7C | SNV | Missense_Mutation | novel | c.308C>T | p.Ser103Leu | p.S103L | Q8WUZ0 | protein_coding | deleterious(0.03) | possibly_damaging(0.838) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
BCL7C | SNV | Missense_Mutation | novel | c.94G>A | p.Glu32Lys | p.E32K | Q8WUZ0 | protein_coding | deleterious(0.01) | benign(0.048) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
BCL7C | SNV | Missense_Mutation | rs375059314 | c.424N>T | p.Arg142Trp | p.R142W | Q8WUZ0 | protein_coding | deleterious(0.02) | benign(0) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BCL7C | SNV | Missense_Mutation | c.425N>A | p.Arg142Gln | p.R142Q | Q8WUZ0 | protein_coding | tolerated(0.55) | benign(0) | TCGA-BR-7196-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD | |
BCL7C | SNV | Missense_Mutation | rs188345023 | c.208N>T | p.Arg70Cys | p.R70C | Q8WUZ0 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-CD-8529-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | epirubicin | CR |
BCL7C | SNV | Missense_Mutation | c.191N>A | p.Gly64Asp | p.G64D | Q8WUZ0 | protein_coding | tolerated(0.15) | possibly_damaging(0.744) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |