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Gene: BCHE |
Gene summary for BCHE |
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Gene information | Species | Human | Gene symbol | BCHE | Gene ID | 590 |
Gene name | butyrylcholinesterase | |
Gene Alias | BCHED | |
Cytomap | 3q26.1 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | P06276 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
590 | BCHE | P2T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.18e-01 | 0.1177 |
590 | BCHE | P10T-E | Human | Esophagus | ESCC | 1.43e-42 | 8.10e-01 | 0.116 |
590 | BCHE | P11T-E | Human | Esophagus | ESCC | 9.07e-04 | 2.52e-01 | 0.1426 |
590 | BCHE | P12T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.01e-01 | 0.1122 |
590 | BCHE | P22T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.07e-02 | 0.1236 |
590 | BCHE | P26T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.52e-01 | 0.1276 |
590 | BCHE | P30T-E | Human | Esophagus | ESCC | 4.84e-02 | 1.61e-01 | 0.137 |
590 | BCHE | P32T-E | Human | Esophagus | ESCC | 1.85e-18 | 4.01e-01 | 0.1666 |
590 | BCHE | P37T-E | Human | Esophagus | ESCC | 5.37e-05 | 1.69e-01 | 0.1371 |
590 | BCHE | P40T-E | Human | Esophagus | ESCC | 6.35e-03 | 1.42e-01 | 0.109 |
590 | BCHE | P61T-E | Human | Esophagus | ESCC | 3.65e-02 | 1.04e-01 | 0.099 |
590 | BCHE | P62T-E | Human | Esophagus | ESCC | 1.16e-21 | 4.38e-01 | 0.1302 |
590 | BCHE | P74T-E | Human | Esophagus | ESCC | 8.96e-18 | 5.31e-01 | 0.1479 |
590 | BCHE | P89T-E | Human | Esophagus | ESCC | 3.35e-02 | 3.46e-01 | 0.1752 |
590 | BCHE | P107T-E | Human | Esophagus | ESCC | 4.67e-06 | 1.52e-01 | 0.171 |
590 | BCHE | HTA12-23-1 | Human | Pancreas | PDAC | 1.44e-05 | 5.53e-01 | 0.3405 |
590 | BCHE | HTA12-25-1 | Human | Pancreas | PDAC | 3.07e-08 | 5.45e-01 | 0.313 |
590 | BCHE | HTA12-26-1 | Human | Pancreas | PDAC | 7.59e-10 | 5.37e-01 | 0.3728 |
590 | BCHE | HTA12-29-1 | Human | Pancreas | PDAC | 5.86e-19 | 5.00e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:0048545111 | Esophagus | ESCC | response to steroid hormone | 204/8552 | 339/18723 | 4.47e-08 | 8.11e-07 | 204 |
GO:000758410 | Esophagus | ESCC | response to nutrient | 114/8552 | 174/18723 | 9.43e-08 | 1.56e-06 | 114 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:00332734 | Esophagus | ESCC | response to vitamin | 60/8552 | 93/18723 | 1.89e-04 | 1.21e-03 | 60 |
GO:003196020 | Esophagus | ESCC | response to corticosteroid | 95/8552 | 167/18723 | 2.27e-03 | 9.99e-03 | 95 |
GO:005138420 | Esophagus | ESCC | response to glucocorticoid | 85/8552 | 148/18723 | 2.60e-03 | 1.11e-02 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCHE | SNV | Missense_Mutation | c.407N>A | p.Thr136Asn | p.T136N | P06276 | protein_coding | deleterious(0.02) | possibly_damaging(0.649) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
BCHE | SNV | Missense_Mutation | c.493N>A | p.Glu165Lys | p.E165K | P06276 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
BCHE | SNV | Missense_Mutation | c.935N>G | p.Thr312Ser | p.T312S | P06276 | protein_coding | tolerated(1) | benign(0) | TCGA-JW-A5VG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
BCHE | SNV | Missense_Mutation | c.1534N>G | p.Gln512Glu | p.Q512E | P06276 | protein_coding | tolerated(1) | benign(0.007) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
BCHE | SNV | Missense_Mutation | c.1355N>A | p.Arg452Gln | p.R452Q | P06276 | protein_coding | deleterious(0.05) | benign(0.12) | TCGA-A6-6650-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BCHE | SNV | Missense_Mutation | c.401A>T | p.Asn134Ile | p.N134I | P06276 | protein_coding | deleterious(0.02) | possibly_damaging(0.839) | TCGA-A6-A56B-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD | |
BCHE | SNV | Missense_Mutation | rs762936157 | c.990N>A | p.Met330Ile | p.M330I | P06276 | protein_coding | tolerated(0.15) | benign(0.015) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BCHE | SNV | Missense_Mutation | c.1409N>G | p.Ile470Ser | p.I470S | P06276 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
BCHE | SNV | Missense_Mutation | c.1761N>A | p.Asn587Lys | p.N587K | P06276 | protein_coding | deleterious(0.01) | benign(0.148) | TCGA-AA-A01V-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BCHE | SNV | Missense_Mutation | c.1028N>A | p.Thr343Asn | p.T343N | P06276 | protein_coding | tolerated(0.06) | possibly_damaging(0.86) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
590 | BCHE | DRUGGABLE GENOME, ENZYME | RVT-103+RVT-104 | |||
590 | BCHE | DRUGGABLE GENOME, ENZYME | rivastigmine | RIVASTIGMINE | 18780301,25376930,17047484,12668920 | |
590 | BCHE | DRUGGABLE GENOME, ENZYME | IMMUNOTOXIN | 10198815 | ||
590 | BCHE | DRUGGABLE GENOME, ENZYME | MEPTAZINOL | MEPTAZINOL | ||
590 | BCHE | DRUGGABLE GENOME, ENZYME | Tetra-hydro-isoquinoline derivative 2 | |||
590 | BCHE | DRUGGABLE GENOME, ENZYME | Succinylcholine | SUXAMETHONIUM | ||
590 | BCHE | DRUGGABLE GENOME, ENZYME | Tetra-hydro-isoquinoline derivative 1 | |||
590 | BCHE | DRUGGABLE GENOME, ENZYME | RIVASTIGMINE | RIVASTIGMINE | ||
590 | BCHE | DRUGGABLE GENOME, ENZYME | ISOFLUROPHATE | ISOFLUROPHATE | ||
590 | BCHE | DRUGGABLE GENOME, ENZYME | Quinazoline alkaloid derivative 1 |
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