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Gene: BCAS4 |
Gene summary for BCAS4 |
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Gene information | Species | Human | Gene symbol | BCAS4 | Gene ID | 55653 |
Gene name | breast carcinoma amplified sequence 4 | |
Gene Alias | CNOL | |
Cytomap | 20q13.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8TDM0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55653 | BCAS4 | GSM4909281 | Human | Breast | IDC | 6.95e-03 | 1.26e-01 | 0.21 |
55653 | BCAS4 | GSM4909286 | Human | Breast | IDC | 4.32e-07 | 2.37e-01 | 0.1081 |
55653 | BCAS4 | GSM4909293 | Human | Breast | IDC | 2.90e-02 | 1.13e-01 | 0.1581 |
55653 | BCAS4 | GSM4909298 | Human | Breast | IDC | 2.15e-06 | 1.85e-01 | 0.1551 |
55653 | BCAS4 | GSM4909301 | Human | Breast | IDC | 1.20e-05 | 2.71e-01 | 0.1577 |
55653 | BCAS4 | GSM4909302 | Human | Breast | IDC | 1.87e-06 | 2.76e-01 | 0.1545 |
55653 | BCAS4 | GSM4909304 | Human | Breast | IDC | 2.46e-11 | 3.47e-01 | 0.1636 |
55653 | BCAS4 | GSM4909306 | Human | Breast | IDC | 5.69e-05 | 1.59e-01 | 0.1564 |
55653 | BCAS4 | GSM4909307 | Human | Breast | IDC | 1.17e-11 | 3.53e-01 | 0.1569 |
55653 | BCAS4 | GSM4909308 | Human | Breast | IDC | 8.28e-25 | 5.03e-01 | 0.158 |
55653 | BCAS4 | GSM4909315 | Human | Breast | IDC | 4.27e-02 | 1.51e-01 | 0.21 |
55653 | BCAS4 | GSM4909317 | Human | Breast | IDC | 7.96e-07 | 2.31e-01 | 0.1355 |
55653 | BCAS4 | GSM4909319 | Human | Breast | IDC | 4.34e-06 | 1.57e-01 | 0.1563 |
55653 | BCAS4 | GSM4909321 | Human | Breast | IDC | 9.70e-05 | 2.67e-01 | 0.1559 |
55653 | BCAS4 | ctrl6 | Human | Breast | Precancer | 4.57e-08 | 3.62e-01 | -0.0061 |
55653 | BCAS4 | brca2 | Human | Breast | Precancer | 8.35e-03 | 1.51e-01 | -0.024 |
55653 | BCAS4 | brca3 | Human | Breast | Precancer | 2.73e-03 | 1.16e-01 | -0.0263 |
55653 | BCAS4 | brca10 | Human | Breast | Precancer | 8.61e-26 | 6.11e-01 | -0.0029 |
55653 | BCAS4 | M1 | Human | Breast | IDC | 1.17e-09 | 3.35e-01 | 0.1577 |
55653 | BCAS4 | DCIS2 | Human | Breast | DCIS | 4.20e-05 | -2.66e-02 | 0.0085 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCAS4 | SNV | Missense_Mutation | c.419G>T | p.Arg140Leu | p.R140L | Q8TDM0 | protein_coding | deleterious(0.03) | possibly_damaging(0.653) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BCAS4 | SNV | Missense_Mutation | novel | c.411G>T | p.Gln137His | p.Q137H | Q8TDM0 | protein_coding | deleterious(0.01) | probably_damaging(0.958) | TCGA-56-A62T-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
BCAS4 | SNV | Missense_Mutation | novel | c.412G>T | p.Ala138Ser | p.A138S | Q8TDM0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-56-A62T-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
BCAS4 | SNV | Missense_Mutation | c.321N>A | p.Met107Ile | p.M107I | Q8TDM0 | protein_coding | deleterious(0.04) | benign(0.029) | TCGA-J9-A52D-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | |
BCAS4 | SNV | Missense_Mutation | rs368879764 | c.419N>A | p.Arg140Gln | p.R140Q | Q8TDM0 | protein_coding | tolerated(0.08) | possibly_damaging(0.521) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
BCAS4 | SNV | Missense_Mutation | rs564853296 | c.613N>A | p.Val205Ile | p.V205I | Q8TDM0 | protein_coding | tolerated_low_confidence(0.43) | benign(0.015) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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