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Gene: ATP2A3 |
Gene summary for ATP2A3 |
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Gene information | Species | Human | Gene symbol | ATP2A3 | Gene ID | 489 |
Gene name | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 | |
Gene Alias | SERCA3 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A8K9K1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
489 | ATP2A3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.99e-07 | 5.96e-01 | -0.1808 |
489 | ATP2A3 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.21e-06 | 4.74e-01 | -0.1954 |
489 | ATP2A3 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.01e-04 | 1.15e+00 | -0.2602 |
489 | ATP2A3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 9.08e-08 | 1.32e+00 | -0.2196 |
489 | ATP2A3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.76e-02 | 3.69e-01 | -0.1207 |
489 | ATP2A3 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.70e-35 | 1.18e+00 | -0.1464 |
489 | ATP2A3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.03e-14 | 5.88e-01 | -0.1001 |
489 | ATP2A3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.14e-04 | 7.79e-01 | -0.1706 |
489 | ATP2A3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.68e-03 | 6.15e-01 | -0.0842 |
489 | ATP2A3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.19e-03 | -2.72e-01 | 0.294 |
489 | ATP2A3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.71e-08 | -3.43e-01 | 0.3859 |
489 | ATP2A3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.06e-03 | -3.58e-01 | 0.2585 |
489 | ATP2A3 | A015-C-203 | Human | Colorectum | FAP | 3.81e-11 | 4.16e-01 | -0.1294 |
489 | ATP2A3 | A001-C-119 | Human | Colorectum | FAP | 1.23e-02 | 4.30e-01 | -0.1557 |
489 | ATP2A3 | A002-C-205 | Human | Colorectum | FAP | 2.35e-04 | -6.09e-02 | -0.1236 |
489 | ATP2A3 | A015-C-005 | Human | Colorectum | FAP | 8.30e-06 | 5.65e-01 | -0.0336 |
489 | ATP2A3 | A015-C-006 | Human | Colorectum | FAP | 1.74e-04 | 2.46e-01 | -0.0994 |
489 | ATP2A3 | A002-C-114 | Human | Colorectum | FAP | 1.66e-07 | 3.64e-01 | -0.1561 |
489 | ATP2A3 | A015-C-104 | Human | Colorectum | FAP | 4.07e-08 | 3.14e-01 | -0.1899 |
489 | ATP2A3 | A002-C-016 | Human | Colorectum | FAP | 1.46e-02 | 6.83e-02 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0043281 | Colorectum | AD | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 72/3918 | 209/18723 | 3.70e-06 | 1.03e-04 | 72 |
GO:2000116 | Colorectum | AD | regulation of cysteine-type endopeptidase activity | 79/3918 | 235/18723 | 3.74e-06 | 1.03e-04 | 79 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
GO:0010952 | Colorectum | AD | positive regulation of peptidase activity | 68/3918 | 197/18723 | 6.30e-06 | 1.59e-04 | 68 |
GO:0070059 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 29/3918 | 63/18723 | 7.03e-06 | 1.73e-04 | 29 |
GO:0052548 | Colorectum | AD | regulation of endopeptidase activity | 124/3918 | 432/18723 | 6.58e-05 | 1.07e-03 | 124 |
GO:0010950 | Colorectum | AD | positive regulation of endopeptidase activity | 59/3918 | 179/18723 | 1.11e-04 | 1.65e-03 | 59 |
GO:2001056 | Colorectum | AD | positive regulation of cysteine-type endopeptidase activity | 47/3918 | 148/18723 | 1.30e-03 | 1.14e-02 | 47 |
GO:0043280 | Colorectum | AD | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 42/3918 | 129/18723 | 1.33e-03 | 1.16e-02 | 42 |
GO:0051100 | Colorectum | AD | negative regulation of binding | 50/3918 | 162/18723 | 1.84e-03 | 1.51e-02 | 50 |
GO:0032091 | Colorectum | AD | negative regulation of protein binding | 30/3918 | 94/18723 | 8.26e-03 | 4.85e-02 | 30 |
GO:00458621 | Colorectum | SER | positive regulation of proteolysis | 106/2897 | 372/18723 | 8.40e-11 | 1.20e-08 | 106 |
GO:00971931 | Colorectum | SER | intrinsic apoptotic signaling pathway | 87/2897 | 288/18723 | 1.67e-10 | 2.32e-08 | 87 |
GO:00510981 | Colorectum | SER | regulation of binding | 97/2897 | 363/18723 | 1.98e-08 | 1.43e-06 | 97 |
GO:00349761 | Colorectum | SER | response to endoplasmic reticulum stress | 74/2897 | 256/18723 | 3.01e-08 | 2.05e-06 | 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa05017 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa04260 | Colorectum | AD | Cardiac muscle contraction | 32/2092 | 87/8465 | 7.92e-03 | 3.13e-02 | 2.00e-02 | 32 |
hsa04972 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa050171 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa042601 | Colorectum | AD | Cardiac muscle contraction | 32/2092 | 87/8465 | 7.92e-03 | 3.13e-02 | 2.00e-02 | 32 |
hsa049721 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050172 | Colorectum | SER | Spinocerebellar ataxia | 46/1580 | 143/8465 | 6.78e-05 | 7.51e-04 | 5.45e-04 | 46 |
hsa049192 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa042602 | Colorectum | SER | Cardiac muscle contraction | 31/1580 | 87/8465 | 1.30e-04 | 1.30e-03 | 9.47e-04 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP2A3 | SNV | Missense_Mutation | rs772135441 | c.2464N>T | p.Arg822Trp | p.R822W | Q93084 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATP2A3 | SNV | Missense_Mutation | novel | c.1708N>T | p.Pro570Ser | p.P570S | Q93084 | protein_coding | tolerated(0.06) | benign(0.209) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATP2A3 | SNV | Missense_Mutation | c.2476N>A | p.Glu826Lys | p.E826K | Q93084 | protein_coding | deleterious(0.01) | possibly_damaging(0.882) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP2A3 | SNV | Missense_Mutation | c.2728T>C | p.Cys910Arg | p.C910R | Q93084 | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-Q1-A6DW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ATP2A3 | SNV | Missense_Mutation | c.2155N>A | p.Ala719Thr | p.A719T | Q93084 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP2A3 | SNV | Missense_Mutation | c.2976G>A | p.Met992Ile | p.M992I | Q93084 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP2A3 | SNV | Missense_Mutation | novel | c.1693N>A | p.Ala565Thr | p.A565T | Q93084 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ATP2A3 | SNV | Missense_Mutation | rs751615148 | c.2414C>T | p.Thr805Met | p.T805M | Q93084 | protein_coding | deleterious(0.01) | possibly_damaging(0.455) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
ATP2A3 | SNV | Missense_Mutation | c.1231N>A | p.Val411Met | p.V411M | Q93084 | protein_coding | tolerated(0.07) | benign(0.015) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ATP2A3 | SNV | Missense_Mutation | c.1466G>A | p.Arg489Gln | p.R489Q | Q93084 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
489 | ATP2A3 | DRUGGABLE GENOME, TRANSPORTER, ENZYME | celecoxib | CELECOXIB | 22336956 |
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