![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ARRDC3 |
Gene summary for ARRDC3 |
![]() |
Gene information | Species | Human | Gene symbol | ARRDC3 | Gene ID | 57561 |
Gene name | arrestin domain containing 3 | |
Gene Alias | TLIMP | |
Cytomap | 5q14.3 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q96B67 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57561 | ARRDC3 | CCI_2 | Human | Cervix | CC | 1.73e-05 | 7.39e-01 | 0.5249 |
57561 | ARRDC3 | CCI_3 | Human | Cervix | CC | 4.51e-08 | 7.76e-01 | 0.516 |
57561 | ARRDC3 | sample3 | Human | Cervix | CC | 4.44e-02 | 2.22e-01 | 0.1387 |
57561 | ARRDC3 | H2 | Human | Cervix | HSIL_HPV | 1.30e-02 | 2.49e-01 | 0.0632 |
57561 | ARRDC3 | TD9 | Human | Lung | IAC | 6.91e-05 | 7.72e-01 | 0.088 |
57561 | ARRDC3 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.83e-03 | 7.40e-01 | -0.1406 |
57561 | ARRDC3 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 2.16e-04 | 7.10e-01 | -0.1408 |
57561 | ARRDC3 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 6.19e-03 | 5.90e-01 | -0.138 |
57561 | ARRDC3 | RNA-P17T-P17T-2 | Human | Lung | IAC | 9.09e-03 | 1.32e-01 | 0.3371 |
57561 | ARRDC3 | RNA-P17T-P17T-4 | Human | Lung | IAC | 9.53e-06 | 3.32e-01 | 0.343 |
57561 | ARRDC3 | RNA-P17T-P17T-8 | Human | Lung | IAC | 2.82e-08 | 3.18e-01 | 0.3329 |
57561 | ARRDC3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 4.77e-07 | 1.68e-01 | -0.2116 |
57561 | ARRDC3 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 5.11e-03 | 2.66e-01 | -0.1941 |
57561 | ARRDC3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.06e-02 | 1.51e-01 | -0.2119 |
57561 | ARRDC3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 5.81e-05 | 6.18e-02 | -0.0166 |
57561 | ARRDC3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.08e-11 | 7.77e-02 | -0.0132 |
57561 | ARRDC3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.70e-13 | 6.02e-02 | -0.013 |
57561 | ARRDC3 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 9.50e-08 | 1.66e-01 | -0.0121 |
57561 | ARRDC3 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 6.84e-12 | 8.50e-01 | -0.0961 |
57561 | ARRDC3 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 1.25e-08 | 6.84e-01 | -0.0876 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:190332010 | Cervix | CC | regulation of protein modification by small protein conjugation or removal | 66/2311 | 242/18723 | 2.31e-10 | 3.46e-08 | 66 |
GO:003139610 | Cervix | CC | regulation of protein ubiquitination | 59/2311 | 210/18723 | 5.90e-10 | 7.51e-08 | 59 |
GO:00400133 | Cervix | CC | negative regulation of locomotion | 76/2311 | 391/18723 | 3.47e-05 | 5.60e-04 | 76 |
GO:00514387 | Cervix | CC | regulation of ubiquitin-protein transferase activity | 18/2311 | 53/18723 | 3.69e-05 | 5.84e-04 | 18 |
GO:00313983 | Cervix | CC | positive regulation of protein ubiquitination | 25/2311 | 119/18723 | 5.09e-03 | 3.01e-02 | 25 |
GO:19033224 | Cervix | CC | positive regulation of protein modification by small protein conjugation or removal | 28/2311 | 138/18723 | 5.26e-03 | 3.08e-02 | 28 |
GO:003139615 | Cervix | HSIL_HPV | regulation of protein ubiquitination | 33/737 | 210/18723 | 1.02e-11 | 6.81e-09 | 33 |
GO:190332015 | Cervix | HSIL_HPV | regulation of protein modification by small protein conjugation or removal | 34/737 | 242/18723 | 1.16e-10 | 4.31e-08 | 34 |
GO:004358813 | Cervix | HSIL_HPV | skin development | 31/737 | 263/18723 | 5.32e-08 | 3.89e-06 | 31 |
GO:005143815 | Cervix | HSIL_HPV | regulation of ubiquitin-protein transferase activity | 11/737 | 53/18723 | 5.49e-06 | 2.07e-04 | 11 |
GO:003139812 | Cervix | HSIL_HPV | positive regulation of protein ubiquitination | 13/737 | 119/18723 | 8.24e-04 | 1.07e-02 | 13 |
GO:190332212 | Cervix | HSIL_HPV | positive regulation of protein modification by small protein conjugation or removal | 13/737 | 138/18723 | 3.16e-03 | 2.88e-02 | 13 |
GO:19033208 | Lung | IAC | regulation of protein modification by small protein conjugation or removal | 64/2061 | 242/18723 | 1.38e-11 | 4.83e-09 | 64 |
GO:00313968 | Lung | IAC | regulation of protein ubiquitination | 53/2061 | 210/18723 | 4.65e-09 | 7.07e-07 | 53 |
GO:19033223 | Lung | IAC | positive regulation of protein modification by small protein conjugation or removal | 31/2061 | 138/18723 | 8.03e-05 | 1.65e-03 | 31 |
GO:00435882 | Lung | IAC | skin development | 49/2061 | 263/18723 | 1.56e-04 | 2.82e-03 | 49 |
GO:00313982 | Lung | IAC | positive regulation of protein ubiquitination | 26/2061 | 119/18723 | 4.61e-04 | 6.77e-03 | 26 |
GO:00514385 | Lung | IAC | regulation of ubiquitin-protein transferase activity | 14/2061 | 53/18723 | 1.39e-03 | 1.53e-02 | 14 |
GO:0040013 | Lung | IAC | negative regulation of locomotion | 60/2061 | 391/18723 | 4.94e-03 | 3.78e-02 | 60 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARRDC3 | SNV | Missense_Mutation | novel | c.137N>A | p.Ser46Tyr | p.S46Y | Q96B67 | protein_coding | deleterious(0) | benign(0.444) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARRDC3 | SNV | Missense_Mutation | novel | c.146N>G | p.Ile49Ser | p.I49S | Q96B67 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARRDC3 | SNV | Missense_Mutation | c.1078A>G | p.Asn360Asp | p.N360D | Q96B67 | protein_coding | tolerated(0.4) | benign(0) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
ARRDC3 | SNV | Missense_Mutation | novel | c.980N>G | p.Gln327Arg | p.Q327R | Q96B67 | protein_coding | tolerated(0.21) | benign(0.033) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARRDC3 | SNV | Missense_Mutation | novel | c.203N>C | p.Asn68Thr | p.N68T | Q96B67 | protein_coding | tolerated(0.07) | benign(0.187) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARRDC3 | SNV | Missense_Mutation | novel | c.137N>A | p.Ser46Tyr | p.S46Y | Q96B67 | protein_coding | deleterious(0) | benign(0.444) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARRDC3 | insertion | Frame_Shift_Ins | novel | c.171_172insA | p.Arg58ThrfsTer4 | p.R58Tfs*4 | Q96B67 | protein_coding | TCGA-CA-6719-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
ARRDC3 | SNV | Missense_Mutation | rs777796833 | c.1075N>T | p.Arg359Trp | p.R359W | Q96B67 | protein_coding | tolerated(0.05) | benign(0.165) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARRDC3 | SNV | Missense_Mutation | c.850N>T | p.Arg284Cys | p.R284C | Q96B67 | protein_coding | tolerated(0.06) | possibly_damaging(0.88) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARRDC3 | SNV | Missense_Mutation | c.751N>T | p.Arg251Cys | p.R251C | Q96B67 | protein_coding | tolerated(0.12) | probably_damaging(0.998) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |