Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ARRDC1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ARRDC1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ARRDC1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ARRDC1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ARRDC1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ARRDC1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:01401128 | Esophagus | ESCC | extracellular vesicle biogenesis | 20/8552 | 23/18723 | 4.97e-05 | 3.86e-04 | 20 |
GO:0045746 | Esophagus | ESCC | negative regulation of Notch signaling pathway | 28/8552 | 36/18723 | 8.62e-05 | 6.22e-04 | 28 |
GO:00085935 | Esophagus | ESCC | regulation of Notch signaling pathway | 59/8552 | 95/18723 | 9.12e-04 | 4.65e-03 | 59 |
GO:01401125 | Liver | Cirrhotic | extracellular vesicle biogenesis | 14/4634 | 23/18723 | 2.50e-04 | 2.26e-03 | 14 |
GO:014011211 | Liver | HCC | extracellular vesicle biogenesis | 17/7958 | 23/18723 | 2.28e-03 | 1.13e-02 | 17 |
GO:00072196 | Oral cavity | OSCC | Notch signaling pathway | 92/7305 | 172/18723 | 7.84e-05 | 6.08e-04 | 92 |
GO:00085934 | Oral cavity | OSCC | regulation of Notch signaling pathway | 53/7305 | 95/18723 | 6.64e-04 | 3.72e-03 | 53 |
GO:01401127 | Oral cavity | OSCC | extracellular vesicle biogenesis | 17/7305 | 23/18723 | 7.28e-04 | 3.98e-03 | 17 |
GO:014011213 | Oral cavity | LP | extracellular vesicle biogenesis | 14/4623 | 23/18723 | 2.44e-04 | 2.59e-03 | 14 |
GO:000859311 | Oral cavity | LP | regulation of Notch signaling pathway | 35/4623 | 95/18723 | 5.53e-03 | 3.34e-02 | 35 |
GO:000721913 | Oral cavity | LP | Notch signaling pathway | 57/4623 | 172/18723 | 7.60e-03 | 4.18e-02 | 57 |
GO:01401126 | Prostate | BPH | extracellular vesicle biogenesis | 12/3107 | 23/18723 | 9.46e-05 | 8.88e-04 | 12 |
GO:00072195 | Prostate | BPH | Notch signaling pathway | 41/3107 | 172/18723 | 8.95e-03 | 3.83e-02 | 41 |
GO:014011212 | Prostate | Tumor | extracellular vesicle biogenesis | 12/3246 | 23/18723 | 1.47e-04 | 1.33e-03 | 12 |
GO:000721912 | Prostate | Tumor | Notch signaling pathway | 44/3246 | 172/18723 | 4.02e-03 | 2.04e-02 | 44 |
GO:01401129 | Skin | cSCC | extracellular vesicle biogenesis | 15/4864 | 23/18723 | 8.72e-05 | 8.21e-04 | 15 |
GO:000721922 | Skin | cSCC | Notch signaling pathway | 60/4864 | 172/18723 | 5.82e-03 | 2.87e-02 | 60 |
GO:014011210 | Thyroid | PTC | extracellular vesicle biogenesis | 18/5968 | 23/18723 | 6.38e-06 | 7.63e-05 | 18 |
GO:00072199 | Thyroid | PTC | Notch signaling pathway | 70/5968 | 172/18723 | 8.82e-03 | 3.67e-02 | 70 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARRDC1 | SNV | Missense_Mutation | novel | c.482N>C | p.Val161Ala | p.V161A | Q8N5I2 | protein_coding | deleterious(0.05) | possibly_damaging(0.82) | TCGA-AP-A1DM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARRDC1 | SNV | Missense_Mutation | novel | c.220N>A | p.Ala74Thr | p.A74T | Q8N5I2 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARRDC1 | SNV | Missense_Mutation | novel | c.641N>A | p.Arg214His | p.R214H | Q8N5I2 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARRDC1 | SNV | Missense_Mutation | rs752265461 | c.781N>A | p.Asp261Asn | p.D261N | Q8N5I2 | protein_coding | deleterious(0.02) | probably_damaging(0.961) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ARRDC1 | SNV | Missense_Mutation | novel | c.641N>A | p.Arg214His | p.R214H | Q8N5I2 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARRDC1 | SNV | Missense_Mutation | rs201795480 | c.385G>A | p.Val129Met | p.V129M | Q8N5I2 | protein_coding | tolerated(0.1) | possibly_damaging(0.786) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARRDC1 | SNV | Missense_Mutation | novel | c.562N>A | p.Asp188Asn | p.D188N | Q8N5I2 | protein_coding | tolerated(0.4) | benign(0.121) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARRDC1 | SNV | Missense_Mutation | rs368553334 | c.565N>A | p.Val189Ile | p.V189I | Q8N5I2 | protein_coding | tolerated(1) | benign(0) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARRDC1 | SNV | Missense_Mutation | novel | c.1234T>C | p.Tyr412His | p.Y412H | Q8N5I2 | protein_coding | tolerated(0.56) | benign(0) | TCGA-EY-A2OQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARRDC1 | deletion | Frame_Shift_Del | rs781772629 | c.1168delN | p.Pro392GlnfsTer8 | p.P392Qfs*8 | Q8N5I2 | protein_coding | | | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |