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Gene: ARMCX5 |
Gene summary for ARMCX5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ARMCX5 | Gene ID | 64860 |
| Gene name | armadillo repeat containing X-linked 5 | |
| Gene Alias | GASP5 | |
| Cytomap | Xq22.1 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6P1M9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64860 | ARMCX5 | LZE4T | Human | Esophagus | ESCC | 1.31e-02 | 9.67e-02 | 0.0811 |
| 64860 | ARMCX5 | LZE24T | Human | Esophagus | ESCC | 1.07e-04 | 1.11e-01 | 0.0596 |
| 64860 | ARMCX5 | P1T-E | Human | Esophagus | ESCC | 6.30e-05 | 2.35e-01 | 0.0875 |
| 64860 | ARMCX5 | P2T-E | Human | Esophagus | ESCC | 1.01e-22 | 4.27e-01 | 0.1177 |
| 64860 | ARMCX5 | P4T-E | Human | Esophagus | ESCC | 2.68e-22 | 3.51e-01 | 0.1323 |
| 64860 | ARMCX5 | P5T-E | Human | Esophagus | ESCC | 3.39e-13 | 8.29e-02 | 0.1327 |
| 64860 | ARMCX5 | P8T-E | Human | Esophagus | ESCC | 8.19e-16 | 2.23e-01 | 0.0889 |
| 64860 | ARMCX5 | P9T-E | Human | Esophagus | ESCC | 8.00e-11 | 1.91e-01 | 0.1131 |
| 64860 | ARMCX5 | P10T-E | Human | Esophagus | ESCC | 3.30e-24 | 3.43e-01 | 0.116 |
| 64860 | ARMCX5 | P11T-E | Human | Esophagus | ESCC | 2.41e-08 | 2.56e-01 | 0.1426 |
| 64860 | ARMCX5 | P12T-E | Human | Esophagus | ESCC | 3.26e-19 | 3.17e-01 | 0.1122 |
| 64860 | ARMCX5 | P15T-E | Human | Esophagus | ESCC | 1.05e-14 | 2.55e-01 | 0.1149 |
| 64860 | ARMCX5 | P16T-E | Human | Esophagus | ESCC | 3.39e-19 | 1.63e-01 | 0.1153 |
| 64860 | ARMCX5 | P17T-E | Human | Esophagus | ESCC | 1.05e-07 | 3.34e-01 | 0.1278 |
| 64860 | ARMCX5 | P20T-E | Human | Esophagus | ESCC | 1.81e-17 | 3.56e-01 | 0.1124 |
| 64860 | ARMCX5 | P21T-E | Human | Esophagus | ESCC | 1.73e-16 | 1.39e-01 | 0.1617 |
| 64860 | ARMCX5 | P22T-E | Human | Esophagus | ESCC | 1.12e-11 | 2.02e-01 | 0.1236 |
| 64860 | ARMCX5 | P23T-E | Human | Esophagus | ESCC | 3.82e-15 | 4.32e-01 | 0.108 |
| 64860 | ARMCX5 | P24T-E | Human | Esophagus | ESCC | 8.10e-09 | 1.90e-01 | 0.1287 |
| 64860 | ARMCX5 | P26T-E | Human | Esophagus | ESCC | 2.00e-27 | 4.44e-01 | 0.1276 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ARMCX5 | SNV | Missense_Mutation | c.1071N>G | p.Ile357Met | p.I357M | Q6P1M9 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| ARMCX5 | SNV | Missense_Mutation | novel | c.133A>G | p.Lys45Glu | p.K45E | Q6P1M9 | protein_coding | tolerated(0.07) | benign(0.018) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ARMCX5 | SNV | Missense_Mutation | rs767103137 | c.578N>T | p.Ser193Phe | p.S193F | Q6P1M9 | protein_coding | deleterious(0) | benign(0.026) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ARMCX5 | SNV | Missense_Mutation | c.692N>C | p.Val231Ala | p.V231A | Q6P1M9 | protein_coding | tolerated(0.27) | probably_damaging(0.981) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| ARMCX5 | SNV | Missense_Mutation | novel | c.985G>A | p.Glu329Lys | p.E329K | Q6P1M9 | protein_coding | deleterious(0) | benign(0.299) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| ARMCX5 | SNV | Missense_Mutation | novel | c.1087N>G | p.Asn363Asp | p.N363D | Q6P1M9 | protein_coding | deleterious(0.02) | possibly_damaging(0.79) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ARMCX5 | SNV | Missense_Mutation | novel | c.1408A>C | p.Ile470Leu | p.I470L | Q6P1M9 | protein_coding | tolerated(0.95) | benign(0.076) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ARMCX5 | SNV | Missense_Mutation | novel | c.1645G>T | p.Asp549Tyr | p.D549Y | Q6P1M9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ARMCX5 | SNV | Missense_Mutation | c.1121N>T | p.Ser374Ile | p.S374I | Q6P1M9 | protein_coding | deleterious(0) | benign(0.144) | TCGA-EI-6514-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fu | SD | |
| ARMCX5 | deletion | Frame_Shift_Del | c.1381delN | p.Asn462IlefsTer8 | p.N462Ifs*8 | Q6P1M9 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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