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Gene: ARHGEF35 |
Gene summary for ARHGEF35 |
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Gene information | Species | Human | Gene symbol | ARHGEF35 | Gene ID | 445328 |
Gene name | Rho guanine nucleotide exchange factor 35 | |
Gene Alias | ARHGEF5L | |
Cytomap | 7q35 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A5YM69 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
445328 | ARHGEF35 | LZE4T | Human | Esophagus | ESCC | 2.04e-02 | 7.32e-02 | 0.0811 |
445328 | ARHGEF35 | LZE7T | Human | Esophagus | ESCC | 5.26e-05 | 4.20e-01 | 0.0667 |
445328 | ARHGEF35 | LZE22T | Human | Esophagus | ESCC | 3.41e-03 | 1.96e-01 | 0.068 |
445328 | ARHGEF35 | LZE24T | Human | Esophagus | ESCC | 6.50e-09 | 1.58e-01 | 0.0596 |
445328 | ARHGEF35 | P2T-E | Human | Esophagus | ESCC | 8.55e-05 | 6.40e-02 | 0.1177 |
445328 | ARHGEF35 | P4T-E | Human | Esophagus | ESCC | 4.52e-12 | 2.59e-01 | 0.1323 |
445328 | ARHGEF35 | P5T-E | Human | Esophagus | ESCC | 1.48e-04 | 6.72e-02 | 0.1327 |
445328 | ARHGEF35 | P8T-E | Human | Esophagus | ESCC | 7.09e-11 | 9.10e-02 | 0.0889 |
445328 | ARHGEF35 | P9T-E | Human | Esophagus | ESCC | 2.42e-14 | 3.98e-01 | 0.1131 |
445328 | ARHGEF35 | P10T-E | Human | Esophagus | ESCC | 2.28e-09 | 1.93e-01 | 0.116 |
445328 | ARHGEF35 | P12T-E | Human | Esophagus | ESCC | 9.81e-14 | 3.07e-01 | 0.1122 |
445328 | ARHGEF35 | P15T-E | Human | Esophagus | ESCC | 9.88e-14 | 1.99e-01 | 0.1149 |
445328 | ARHGEF35 | P21T-E | Human | Esophagus | ESCC | 1.12e-10 | 2.25e-01 | 0.1617 |
445328 | ARHGEF35 | P22T-E | Human | Esophagus | ESCC | 1.04e-05 | 5.00e-02 | 0.1236 |
445328 | ARHGEF35 | P23T-E | Human | Esophagus | ESCC | 2.36e-06 | 7.71e-02 | 0.108 |
445328 | ARHGEF35 | P26T-E | Human | Esophagus | ESCC | 6.84e-07 | 1.10e-01 | 0.1276 |
445328 | ARHGEF35 | P28T-E | Human | Esophagus | ESCC | 6.34e-50 | 7.62e-01 | 0.1149 |
445328 | ARHGEF35 | P30T-E | Human | Esophagus | ESCC | 8.26e-14 | 6.14e-01 | 0.137 |
445328 | ARHGEF35 | P31T-E | Human | Esophagus | ESCC | 9.71e-20 | 3.40e-01 | 0.1251 |
445328 | ARHGEF35 | P32T-E | Human | Esophagus | ESCC | 6.60e-12 | 2.57e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF35 | SNV | Missense_Mutation | novel | c.1216T>C | p.Ser406Pro | p.S406P | A5YM69 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF35 | SNV | Missense_Mutation | novel | c.1010N>T | p.Arg337Met | p.R337M | A5YM69 | protein_coding | tolerated(0.05) | benign(0.353) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF35 | SNV | Missense_Mutation | novel | c.907N>A | p.Gly303Ser | p.G303S | A5YM69 | protein_coding | tolerated(0.58) | benign(0.023) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF35 | SNV | Missense_Mutation | rs779913268 | c.1339N>A | p.Ala447Thr | p.A447T | A5YM69 | protein_coding | tolerated(0.59) | benign(0.001) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ARHGEF35 | insertion | Frame_Shift_Ins | novel | c.1437dupA | p.Leu480ThrfsTer28 | p.L480Tfs*28 | A5YM69 | protein_coding | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
ARHGEF35 | SNV | Missense_Mutation | novel | c.659N>T | p.Gly220Val | p.G220V | A5YM69 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-DD-AACT-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF35 | SNV | Missense_Mutation | novel | c.1300N>T | p.Gly434Trp | p.G434W | A5YM69 | protein_coding | deleterious(0) | benign(0.408) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ARHGEF35 | SNV | Missense_Mutation | novel | c.658N>C | p.Gly220Arg | p.G220R | A5YM69 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR |
ARHGEF35 | SNV | Missense_Mutation | novel | c.84N>C | p.Met28Ile | p.M28I | A5YM69 | protein_coding | deleterious(0.04) | benign(0.334) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARHGEF35 | SNV | Missense_Mutation | novel | c.1168G>A | p.Val390Met | p.V390M | A5YM69 | protein_coding | tolerated(0.17) | possibly_damaging(0.557) | TCGA-55-8204-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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