![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ARHGEF10 |
Gene summary for ARHGEF10 |
![]() |
Gene information | Species | Human | Gene symbol | ARHGEF10 | Gene ID | 9639 |
Gene name | Rho guanine nucleotide exchange factor 10 | |
Gene Alias | GEF10 | |
Cytomap | 8p23.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O15013 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9639 | ARHGEF10 | PTC01 | Human | Thyroid | PTC | 2.94e-09 | 1.79e-01 | 0.1899 |
9639 | ARHGEF10 | PTC04 | Human | Thyroid | PTC | 2.72e-08 | 1.80e-01 | 0.1927 |
9639 | ARHGEF10 | PTC05 | Human | Thyroid | PTC | 2.27e-12 | 3.97e-01 | 0.2065 |
9639 | ARHGEF10 | PTC06 | Human | Thyroid | PTC | 1.04e-09 | 3.11e-01 | 0.2057 |
9639 | ARHGEF10 | PTC07 | Human | Thyroid | PTC | 3.43e-13 | 2.35e-01 | 0.2044 |
9639 | ARHGEF10 | ATC11 | Human | Thyroid | ATC | 3.71e-05 | 3.62e-01 | 0.3386 |
9639 | ARHGEF10 | ATC12 | Human | Thyroid | ATC | 1.03e-18 | 3.27e-01 | 0.34 |
9639 | ARHGEF10 | ATC13 | Human | Thyroid | ATC | 9.67e-16 | 2.86e-01 | 0.34 |
9639 | ARHGEF10 | ATC2 | Human | Thyroid | ATC | 5.90e-10 | 7.12e-01 | 0.34 |
9639 | ARHGEF10 | ATC3 | Human | Thyroid | ATC | 4.97e-10 | 5.12e-01 | 0.338 |
9639 | ARHGEF10 | ATC4 | Human | Thyroid | ATC | 3.44e-20 | 3.71e-01 | 0.34 |
9639 | ARHGEF10 | ATC5 | Human | Thyroid | ATC | 6.75e-20 | 3.08e-01 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:006157210 | Cervix | CC | actin filament bundle organization | 44/2311 | 161/18723 | 2.08e-07 | 9.34e-06 | 44 |
GO:005101710 | Cervix | CC | actin filament bundle assembly | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:190290510 | Cervix | CC | positive regulation of supramolecular fiber organization | 50/2311 | 209/18723 | 2.55e-06 | 7.54e-05 | 50 |
GO:005149510 | Cervix | CC | positive regulation of cytoskeleton organization | 50/2311 | 226/18723 | 2.53e-05 | 4.29e-04 | 50 |
GO:003223110 | Cervix | CC | regulation of actin filament bundle assembly | 28/2311 | 105/18723 | 5.19e-05 | 7.79e-04 | 28 |
GO:011002010 | Cervix | CC | regulation of actomyosin structure organization | 27/2311 | 100/18723 | 5.55e-05 | 8.10e-04 | 27 |
GO:00069846 | Cervix | CC | ER-nucleus signaling pathway | 16/2311 | 46/18723 | 7.12e-05 | 9.90e-04 | 16 |
GO:005149210 | Cervix | CC | regulation of stress fiber assembly | 25/2311 | 91/18723 | 7.59e-05 | 1.04e-03 | 25 |
GO:00310329 | Cervix | CC | actomyosin structure organization | 43/2311 | 196/18723 | 1.11e-04 | 1.40e-03 | 43 |
GO:003003810 | Cervix | CC | contractile actin filament bundle assembly | 27/2311 | 106/18723 | 1.63e-04 | 1.94e-03 | 27 |
GO:004314910 | Cervix | CC | stress fiber assembly | 27/2311 | 106/18723 | 1.63e-04 | 1.94e-03 | 27 |
GO:00322339 | Cervix | CC | positive regulation of actin filament bundle assembly | 18/2311 | 63/18723 | 4.39e-04 | 4.39e-03 | 18 |
GO:00514966 | Cervix | CC | positive regulation of stress fiber assembly | 14/2311 | 52/18723 | 3.39e-03 | 2.20e-02 | 14 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF10 | SNV | Missense_Mutation | novel | c.3443N>T | p.Ala1148Val | p.A1148V | O15013 | protein_coding | deleterious(0) | benign(0.15) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ARHGEF10 | SNV | Missense_Mutation | rs144004435 | c.827C>T | p.Ser276Leu | p.S276L | O15013 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
ARHGEF10 | SNV | Missense_Mutation | c.2273N>G | p.Asp758Gly | p.D758G | O15013 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-A56B-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD | |
ARHGEF10 | SNV | Missense_Mutation | c.1877N>G | p.Glu626Gly | p.E626G | O15013 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGEF10 | SNV | Missense_Mutation | c.3937G>A | p.Val1313Ile | p.V1313I | O15013 | protein_coding | tolerated(0.29) | benign(0) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGEF10 | SNV | Missense_Mutation | novel | c.2941N>A | p.Ala981Thr | p.A981T | O15013 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ARHGEF10 | SNV | Missense_Mutation | rs769153898 | c.3344N>T | p.Ala1115Val | p.A1115V | O15013 | protein_coding | tolerated(1) | benign(0.039) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF10 | SNV | Missense_Mutation | c.2875N>G | p.Met959Val | p.M959V | O15013 | protein_coding | deleterious(0.02) | probably_damaging(0.986) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ARHGEF10 | SNV | Missense_Mutation | c.3697N>T | p.Ala1233Ser | p.A1233S | O15013 | protein_coding | tolerated(0.67) | benign(0.001) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGEF10 | SNV | Missense_Mutation | c.668C>T | p.Ala223Val | p.A223V | O15013 | protein_coding | deleterious_low_confidence(0.05) | benign(0.039) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |