|
Gene: APOBEC3C |
Gene summary for APOBEC3C |
Gene summary. |
Gene information | Species | Human | Gene symbol | APOBEC3C | Gene ID | 27350 |
Gene name | apolipoprotein B mRNA editing enzyme catalytic subunit 3C | |
Gene Alias | A3C | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9NRW3 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27350 | APOBEC3C | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.88e-04 | 1.62e-01 | -0.1808 |
27350 | APOBEC3C | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.49e-04 | 1.98e-01 | -0.0811 |
27350 | APOBEC3C | HTA11_347_2000001011 | Human | Colorectum | AD | 1.18e-22 | 4.15e-01 | -0.1954 |
27350 | APOBEC3C | HTA11_411_2000001011 | Human | Colorectum | SER | 4.42e-10 | 5.69e-01 | -0.2602 |
27350 | APOBEC3C | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-03 | 2.67e-01 | -0.1207 |
27350 | APOBEC3C | HTA11_696_2000001011 | Human | Colorectum | AD | 2.46e-16 | 3.75e-01 | -0.1464 |
27350 | APOBEC3C | HTA11_866_2000001011 | Human | Colorectum | AD | 4.46e-07 | 1.89e-01 | -0.1001 |
27350 | APOBEC3C | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.03e-15 | 6.42e-01 | -0.1706 |
27350 | APOBEC3C | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.97e-04 | 2.59e-01 | -0.2061 |
27350 | APOBEC3C | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.79e-01 | -0.0179 |
27350 | APOBEC3C | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 2.47e-01 | 0.0528 |
27350 | APOBEC3C | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.15e-02 | 1.58e-01 | 0.0588 |
27350 | APOBEC3C | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.63e-08 | 1.74e-01 | 0.294 |
27350 | APOBEC3C | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.40e-05 | 6.32e-01 | 0.3487 |
27350 | APOBEC3C | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.38e-06 | 1.42e-01 | 0.3859 |
27350 | APOBEC3C | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.10e-25 | 4.69e-01 | 0.3005 |
27350 | APOBEC3C | LZE4T | Human | Esophagus | ESCC | 1.26e-05 | 1.79e-01 | 0.0811 |
27350 | APOBEC3C | LZE8T | Human | Esophagus | ESCC | 7.07e-03 | 1.94e-02 | 0.067 |
27350 | APOBEC3C | LZE6T | Human | Esophagus | ESCC | 7.16e-04 | 2.86e-01 | 0.0845 |
27350 | APOBEC3C | P2T-E | Human | Esophagus | ESCC | 5.49e-25 | 1.52e-01 | 0.1177 |
Page: 1 2 3 4 5 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
GO:0050792 | Colorectum | AD | regulation of viral process | 59/3918 | 164/18723 | 5.95e-06 | 1.52e-04 | 59 |
GO:1903900 | Colorectum | AD | regulation of viral life cycle | 51/3918 | 148/18723 | 9.01e-05 | 1.38e-03 | 51 |
GO:0045069 | Colorectum | AD | regulation of viral genome replication | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:00160321 | Colorectum | SER | viral process | 118/2897 | 415/18723 | 8.36e-12 | 1.65e-09 | 118 |
GO:00190581 | Colorectum | SER | viral life cycle | 87/2897 | 317/18723 | 2.82e-08 | 1.94e-06 | 87 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:00190791 | Colorectum | SER | viral genome replication | 37/2897 | 131/18723 | 1.36e-04 | 2.72e-03 | 37 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
GO:00467001 | Colorectum | SER | heterocycle catabolic process | 97/2897 | 445/18723 | 2.20e-04 | 3.89e-03 | 97 |
GO:00507921 | Colorectum | SER | regulation of viral process | 43/2897 | 164/18723 | 2.57e-04 | 4.31e-03 | 43 |
GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
Page: 1 2 3 4 5 6 7 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa051702 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa051703 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa051704 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa051705 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa032509 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0325014 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0517027 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa032508 | Oral cavity | OSCC | Viral life cycle - HIV-1 | 45/3704 | 63/8465 | 7.62e-06 | 3.59e-05 | 1.83e-05 | 45 |
hsa05170111 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa0325013 | Oral cavity | OSCC | Viral life cycle - HIV-1 | 45/3704 | 63/8465 | 7.62e-06 | 3.59e-05 | 1.83e-05 | 45 |
hsa0517028 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
hsa0517037 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APOBEC3C | SNV | Missense_Mutation | c.167N>A | p.Arg56Gln | p.R56Q | Q9NRW3 | protein_coding | tolerated(0.38) | benign(0.079) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
APOBEC3C | SNV | Missense_Mutation | c.367N>A | p.Leu123Ile | p.L123I | Q9NRW3 | protein_coding | tolerated(0.06) | probably_damaging(0.948) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
APOBEC3C | SNV | Missense_Mutation | rs138675963 | c.407N>A | p.Arg136His | p.R136H | Q9NRW3 | protein_coding | tolerated(0.07) | benign(0.327) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
APOBEC3C | SNV | Missense_Mutation | rs376538641 | c.134G>A | p.Arg45His | p.R45H | Q9NRW3 | protein_coding | tolerated(0.23) | benign(0.001) | TCGA-A5-A3LO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
APOBEC3C | SNV | Missense_Mutation | c.447C>A | p.Asp149Glu | p.D149E | Q9NRW3 | protein_coding | tolerated(0.19) | benign(0.014) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APOBEC3C | SNV | Missense_Mutation | rs756657821 | c.160N>A | p.Val54Ile | p.V54I | Q9NRW3 | protein_coding | tolerated(0.45) | benign(0.353) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APOBEC3C | SNV | Missense_Mutation | rs200232887 | c.430N>A | p.Ala144Thr | p.A144T | Q9NRW3 | protein_coding | tolerated(0.7) | benign(0.001) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
APOBEC3C | SNV | Missense_Mutation | c.335N>A | p.Ser112Asn | p.S112N | Q9NRW3 | protein_coding | tolerated(0.28) | benign(0.001) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
APOBEC3C | SNV | Missense_Mutation | rs201591623 | c.115N>A | p.Val39Met | p.V39M | Q9NRW3 | protein_coding | tolerated(0.17) | possibly_damaging(0.709) | TCGA-85-A5B5-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APOBEC3C | SNV | Missense_Mutation | novel | c.470N>C | p.Trp157Ser | p.W157S | Q9NRW3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |