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Gene: APEX2 |
Gene summary for APEX2 |
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Gene information | Species | Human | Gene symbol | APEX2 | Gene ID | 27301 |
Gene name | apurinic/apyrimidinic endodeoxyribonuclease 2 | |
Gene Alias | APE2 | |
Cytomap | Xp11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4DWI9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27301 | APEX2 | LZE2T | Human | Esophagus | ESCC | 2.93e-02 | 3.37e-01 | 0.082 |
27301 | APEX2 | LZE4T | Human | Esophagus | ESCC | 1.36e-02 | 9.49e-02 | 0.0811 |
27301 | APEX2 | LZE7T | Human | Esophagus | ESCC | 5.86e-04 | 2.41e-01 | 0.0667 |
27301 | APEX2 | LZE8T | Human | Esophagus | ESCC | 2.06e-07 | 3.51e-01 | 0.067 |
27301 | APEX2 | LZE20T | Human | Esophagus | ESCC | 4.10e-12 | 2.35e-01 | 0.0662 |
27301 | APEX2 | LZE24T | Human | Esophagus | ESCC | 2.45e-19 | 5.62e-01 | 0.0596 |
27301 | APEX2 | LZE6T | Human | Esophagus | ESCC | 5.70e-04 | 1.62e-01 | 0.0845 |
27301 | APEX2 | P1T-E | Human | Esophagus | ESCC | 1.54e-02 | 1.78e-01 | 0.0875 |
27301 | APEX2 | P2T-E | Human | Esophagus | ESCC | 7.60e-25 | 4.29e-01 | 0.1177 |
27301 | APEX2 | P4T-E | Human | Esophagus | ESCC | 4.35e-22 | 4.82e-01 | 0.1323 |
27301 | APEX2 | P5T-E | Human | Esophagus | ESCC | 1.28e-19 | 4.02e-01 | 0.1327 |
27301 | APEX2 | P8T-E | Human | Esophagus | ESCC | 8.49e-13 | 2.75e-01 | 0.0889 |
27301 | APEX2 | P9T-E | Human | Esophagus | ESCC | 4.10e-13 | 3.01e-01 | 0.1131 |
27301 | APEX2 | P10T-E | Human | Esophagus | ESCC | 3.08e-12 | 2.21e-01 | 0.116 |
27301 | APEX2 | P11T-E | Human | Esophagus | ESCC | 6.21e-11 | 3.23e-01 | 0.1426 |
27301 | APEX2 | P12T-E | Human | Esophagus | ESCC | 8.42e-15 | 3.41e-01 | 0.1122 |
27301 | APEX2 | P15T-E | Human | Esophagus | ESCC | 5.38e-18 | 2.53e-01 | 0.1149 |
27301 | APEX2 | P16T-E | Human | Esophagus | ESCC | 5.79e-15 | 2.62e-01 | 0.1153 |
27301 | APEX2 | P17T-E | Human | Esophagus | ESCC | 6.42e-06 | 3.03e-01 | 0.1278 |
27301 | APEX2 | P19T-E | Human | Esophagus | ESCC | 1.73e-06 | 4.09e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00062843 | Esophagus | ESCC | base-excision repair | 33/8552 | 43/18723 | 3.25e-05 | 2.69e-04 | 33 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:0006284 | Liver | HCC | base-excision repair | 27/7958 | 43/18723 | 5.79e-03 | 2.40e-02 | 27 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00062842 | Oral cavity | OSCC | base-excision repair | 28/7305 | 43/18723 | 4.71e-04 | 2.79e-03 | 28 |
GO:0006310 | Oral cavity | OSCC | DNA recombination | 147/7305 | 305/18723 | 6.33e-04 | 3.56e-03 | 147 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APEX2 | SNV | Missense_Mutation | novel | c.940N>C | p.Ser314Pro | p.S314P | Q9UBZ4 | protein_coding | tolerated(0.08) | possibly_damaging(0.543) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
APEX2 | SNV | Missense_Mutation | rs749704346 | c.608N>A | p.Arg203His | p.R203H | Q9UBZ4 | protein_coding | deleterious(0.02) | benign(0.215) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
APEX2 | SNV | Missense_Mutation | c.227N>A | p.Arg76His | p.R76H | Q9UBZ4 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
APEX2 | SNV | Missense_Mutation | rs868705455 | c.803N>A | p.Arg268His | p.R268H | Q9UBZ4 | protein_coding | deleterious(0.03) | probably_damaging(0.985) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APEX2 | SNV | Missense_Mutation | novel | c.1016T>C | p.Ile339Thr | p.I339T | Q9UBZ4 | protein_coding | deleterious(0) | benign(0.424) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
APEX2 | SNV | Missense_Mutation | rs749036434 | c.517C>T | p.Arg173Cys | p.R173C | Q9UBZ4 | protein_coding | deleterious(0) | benign(0.106) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APEX2 | SNV | Missense_Mutation | rs749036434 | c.517N>T | p.Arg173Cys | p.R173C | Q9UBZ4 | protein_coding | deleterious(0) | benign(0.106) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APEX2 | SNV | Missense_Mutation | rs764409927 | c.1393N>T | p.Arg465Cys | p.R465C | Q9UBZ4 | protein_coding | deleterious(0) | benign(0.39) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APEX2 | SNV | Missense_Mutation | c.290N>G | p.Glu97Gly | p.E97G | Q9UBZ4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
APEX2 | SNV | Missense_Mutation | rs764409927 | c.1393C>T | p.Arg465Cys | p.R465C | Q9UBZ4 | protein_coding | deleterious(0) | benign(0.39) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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