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Gene: APCDD1 |
Gene summary for APCDD1 |
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Gene information | Species | Human | Gene symbol | APCDD1 | Gene ID | 147495 |
Gene name | APC down-regulated 1 | |
Gene Alias | B7323 | |
Cytomap | 18p11.22 | |
Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | Q8J025 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147495 | APCDD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.26e-15 | 4.63e-01 | 0.0155 |
147495 | APCDD1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.17e-09 | 5.05e-01 | 0.0216 |
147495 | APCDD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.58e-13 | 6.06e-01 | -0.1464 |
147495 | APCDD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.57e-05 | 3.45e-01 | -0.059 |
147495 | APCDD1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.17e-02 | 4.18e-01 | -0.0842 |
147495 | APCDD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.37e-59 | 1.89e+00 | 0.096 |
147495 | APCDD1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.65e-18 | 1.13e+00 | 0.0338 |
147495 | APCDD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.56e-26 | 6.44e-01 | 0.0674 |
147495 | APCDD1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 9.65e-07 | 8.33e-01 | 0.0397 |
147495 | APCDD1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.21e-39 | 1.03e+00 | 0.294 |
147495 | APCDD1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.14e-46 | 1.29e+00 | 0.3859 |
147495 | APCDD1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.51e-09 | 4.38e-01 | 0.2585 |
147495 | APCDD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.97e-106 | 1.98e+00 | 0.3005 |
147495 | APCDD1 | F007 | Human | Colorectum | FAP | 7.74e-06 | 3.49e-01 | 0.1176 |
147495 | APCDD1 | A002-C-010 | Human | Colorectum | FAP | 6.99e-13 | 4.31e-01 | 0.242 |
147495 | APCDD1 | A001-C-207 | Human | Colorectum | FAP | 1.16e-14 | 5.44e-01 | 0.1278 |
147495 | APCDD1 | A015-C-203 | Human | Colorectum | FAP | 6.20e-20 | 7.45e-01 | -0.1294 |
147495 | APCDD1 | A015-C-204 | Human | Colorectum | FAP | 3.59e-05 | 3.20e-01 | -0.0228 |
147495 | APCDD1 | A002-C-201 | Human | Colorectum | FAP | 3.85e-03 | 2.22e-01 | 0.0324 |
147495 | APCDD1 | A002-C-203 | Human | Colorectum | FAP | 8.13e-03 | 1.93e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:00301112 | Colorectum | MSS | regulation of Wnt signaling pathway | 98/3467 | 328/18723 | 3.37e-07 | 1.36e-05 | 98 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:0030178 | Colorectum | MSS | negative regulation of Wnt signaling pathway | 48/3467 | 170/18723 | 1.23e-03 | 1.18e-02 | 48 |
GO:00160553 | Colorectum | FAP | Wnt signaling pathway | 104/2622 | 444/18723 | 4.92e-08 | 3.92e-06 | 104 |
GO:01987383 | Colorectum | FAP | cell-cell signaling by wnt | 104/2622 | 446/18723 | 6.26e-08 | 4.54e-06 | 104 |
GO:00301113 | Colorectum | FAP | regulation of Wnt signaling pathway | 81/2622 | 328/18723 | 1.44e-07 | 9.03e-06 | 81 |
GO:0043588 | Colorectum | FAP | skin development | 58/2622 | 263/18723 | 2.44e-04 | 3.39e-03 | 58 |
GO:00085441 | Colorectum | FAP | epidermis development | 66/2622 | 324/18723 | 9.63e-04 | 9.51e-03 | 66 |
GO:00301781 | Colorectum | FAP | negative regulation of Wnt signaling pathway | 38/2622 | 170/18723 | 2.06e-03 | 1.70e-02 | 38 |
GO:0022404 | Colorectum | FAP | molting cycle process | 21/2622 | 84/18723 | 5.10e-03 | 3.37e-02 | 21 |
GO:0022405 | Colorectum | FAP | hair cycle process | 21/2622 | 84/18723 | 5.10e-03 | 3.37e-02 | 21 |
GO:00160554 | Colorectum | CRC | Wnt signaling pathway | 88/2078 | 444/18723 | 3.91e-08 | 5.28e-06 | 88 |
GO:01987384 | Colorectum | CRC | cell-cell signaling by wnt | 88/2078 | 446/18723 | 4.85e-08 | 6.04e-06 | 88 |
GO:00301114 | Colorectum | CRC | regulation of Wnt signaling pathway | 68/2078 | 328/18723 | 2.41e-07 | 2.27e-05 | 68 |
GO:00085442 | Colorectum | CRC | epidermis development | 57/2078 | 324/18723 | 2.88e-04 | 4.59e-03 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APCDD1 | SNV | Missense_Mutation | rs771909445 | c.913N>A | p.Glu305Lys | p.E305K | Q8J025 | protein_coding | tolerated(0.15) | possibly_damaging(0.576) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
APCDD1 | SNV | Missense_Mutation | c.95N>T | p.Ser32Ile | p.S32I | Q8J025 | protein_coding | tolerated(0.08) | possibly_damaging(0.483) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
APCDD1 | SNV | Missense_Mutation | rs537794700 | c.413G>A | p.Arg138Gln | p.R138Q | Q8J025 | protein_coding | tolerated(0.06) | possibly_damaging(0.509) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
APCDD1 | SNV | Missense_Mutation | novel | c.1372N>C | p.Ser458Pro | p.S458P | Q8J025 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APCDD1 | SNV | Missense_Mutation | c.773N>G | p.Lys258Arg | p.K258R | Q8J025 | protein_coding | tolerated(0.78) | benign(0.007) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
APCDD1 | SNV | Missense_Mutation | c.760N>A | p.Leu254Met | p.L254M | Q8J025 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-DM-A28A-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
APCDD1 | SNV | Missense_Mutation | rs201834801 | c.896G>A | p.Arg299His | p.R299H | Q8J025 | protein_coding | tolerated(0.17) | possibly_damaging(0.479) | TCGA-AG-3725-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
APCDD1 | SNV | Missense_Mutation | rs115383241 | c.526G>A | p.Ala176Thr | p.A176T | Q8J025 | protein_coding | tolerated(0.14) | benign(0.012) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APCDD1 | SNV | Missense_Mutation | rs746711951 | c.638G>A | p.Arg213Gln | p.R213Q | Q8J025 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
APCDD1 | SNV | Missense_Mutation | c.1364N>T | p.Arg455Ile | p.R455I | Q8J025 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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