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Gene: APBB1IP |
Gene summary for APBB1IP |
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Gene information | Species | Human | Gene symbol | APBB1IP | Gene ID | 54518 |
Gene name | amyloid beta precursor protein binding family B member 1 interacting protein | |
Gene Alias | INAG1 | |
Cytomap | 10p12.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q7Z5R6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54518 | APBB1IP | NAFLD1 | Human | Liver | NAFLD | 3.28e-07 | 8.10e-01 | -0.04 |
54518 | APBB1IP | S43 | Human | Liver | Cirrhotic | 1.03e-07 | -1.64e-01 | -0.0187 |
54518 | APBB1IP | HCC1_Meng | Human | Liver | HCC | 2.21e-25 | -1.55e-01 | 0.0246 |
54518 | APBB1IP | HCC2_Meng | Human | Liver | HCC | 1.10e-06 | -2.25e-01 | 0.0107 |
54518 | APBB1IP | cirrhotic2 | Human | Liver | Cirrhotic | 6.60e-03 | -3.89e-02 | 0.0201 |
54518 | APBB1IP | HCC2 | Human | Liver | HCC | 8.56e-03 | 2.24e+00 | 0.5341 |
54518 | APBB1IP | S029 | Human | Liver | HCC | 2.56e-02 | 4.69e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457857 | Liver | Cirrhotic | positive regulation of cell adhesion | 141/4634 | 437/18723 | 2.05e-04 | 1.89e-03 | 141 |
GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046112 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
hsa0461111 | Liver | HCC | Platelet activation | 71/4020 | 124/8465 | 1.77e-02 | 4.15e-02 | 2.31e-02 | 71 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APBB1IP | SNV | Missense_Mutation | c.224N>G | p.Ile75Arg | p.I75R | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
APBB1IP | SNV | Missense_Mutation | c.1333N>G | p.Thr445Ala | p.T445A | Q7Z5R6 | protein_coding | tolerated(0.05) | benign(0.062) | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APBB1IP | SNV | Missense_Mutation | c.625G>A | p.Glu209Lys | p.E209K | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APBB1IP | SNV | Missense_Mutation | c.531N>T | p.Lys177Asn | p.K177N | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
APBB1IP | SNV | Missense_Mutation | c.988N>T | p.Arg330Cys | p.R330C | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
APBB1IP | SNV | Missense_Mutation | c.100N>G | p.Pro34Ala | p.P34A | Q7Z5R6 | protein_coding | tolerated(0.13) | benign(0.039) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
APBB1IP | SNV | Missense_Mutation | c.1244N>A | p.Arg415Gln | p.R415Q | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APBB1IP | SNV | Missense_Mutation | c.874N>A | p.Ala292Thr | p.A292T | Q7Z5R6 | protein_coding | deleterious(0.03) | benign(0.203) | TCGA-F4-6807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
APBB1IP | SNV | Missense_Mutation | novel | c.909N>A | p.Phe303Leu | p.F303L | Q7Z5R6 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
APBB1IP | deletion | Frame_Shift_Del | c.802delN | p.Asn269ThrfsTer22 | p.N269Tfs*22 | Q7Z5R6 | protein_coding | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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