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Gene: ANKRD50 |
Gene summary for ANKRD50 |
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Gene information | Species | Human | Gene symbol | ANKRD50 | Gene ID | 57182 |
Gene name | ankyrin repeat domain 50 | |
Gene Alias | ANKRD50 | |
Cytomap | 4q28.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8TB46 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57182 | ANKRD50 | LZE4T | Human | Esophagus | ESCC | 1.18e-05 | 2.19e-01 | 0.0811 |
57182 | ANKRD50 | LZE5T | Human | Esophagus | ESCC | 4.10e-02 | 5.35e-01 | 0.0514 |
57182 | ANKRD50 | LZE8T | Human | Esophagus | ESCC | 1.12e-06 | 2.40e-01 | 0.067 |
57182 | ANKRD50 | LZE24T | Human | Esophagus | ESCC | 4.09e-08 | 1.62e-01 | 0.0596 |
57182 | ANKRD50 | P1T-E | Human | Esophagus | ESCC | 1.53e-02 | 2.65e-01 | 0.0875 |
57182 | ANKRD50 | P2T-E | Human | Esophagus | ESCC | 3.01e-16 | 1.50e-01 | 0.1177 |
57182 | ANKRD50 | P4T-E | Human | Esophagus | ESCC | 1.01e-13 | 2.17e-01 | 0.1323 |
57182 | ANKRD50 | P5T-E | Human | Esophagus | ESCC | 2.34e-05 | -1.43e-04 | 0.1327 |
57182 | ANKRD50 | P8T-E | Human | Esophagus | ESCC | 3.50e-12 | 2.56e-01 | 0.0889 |
57182 | ANKRD50 | P9T-E | Human | Esophagus | ESCC | 3.04e-06 | 5.87e-02 | 0.1131 |
57182 | ANKRD50 | P10T-E | Human | Esophagus | ESCC | 1.39e-10 | 1.14e-01 | 0.116 |
57182 | ANKRD50 | P11T-E | Human | Esophagus | ESCC | 1.43e-02 | 1.77e-01 | 0.1426 |
57182 | ANKRD50 | P12T-E | Human | Esophagus | ESCC | 3.29e-19 | 4.77e-01 | 0.1122 |
57182 | ANKRD50 | P15T-E | Human | Esophagus | ESCC | 2.75e-15 | 2.79e-01 | 0.1149 |
57182 | ANKRD50 | P16T-E | Human | Esophagus | ESCC | 1.19e-06 | 7.61e-02 | 0.1153 |
57182 | ANKRD50 | P20T-E | Human | Esophagus | ESCC | 4.40e-07 | 6.07e-02 | 0.1124 |
57182 | ANKRD50 | P21T-E | Human | Esophagus | ESCC | 1.07e-08 | 8.52e-02 | 0.1617 |
57182 | ANKRD50 | P22T-E | Human | Esophagus | ESCC | 3.91e-25 | 3.51e-01 | 0.1236 |
57182 | ANKRD50 | P23T-E | Human | Esophagus | ESCC | 1.20e-07 | 1.67e-01 | 0.108 |
57182 | ANKRD50 | P24T-E | Human | Esophagus | ESCC | 2.75e-03 | 9.14e-03 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:009887615 | Esophagus | ESCC | vesicle-mediated transport to the plasma membrane | 99/8552 | 136/18723 | 1.13e-10 | 3.39e-09 | 99 |
GO:00324565 | Esophagus | ESCC | endocytic recycling | 51/8552 | 73/18723 | 2.47e-05 | 2.10e-04 | 51 |
GO:00988768 | Prostate | BPH | vesicle-mediated transport to the plasma membrane | 43/3107 | 136/18723 | 1.11e-05 | 1.51e-04 | 43 |
GO:00161978 | Prostate | BPH | endosomal transport | 62/3107 | 230/18723 | 4.54e-05 | 4.77e-04 | 62 |
GO:00324563 | Prostate | BPH | endocytic recycling | 21/3107 | 73/18723 | 6.45e-03 | 2.91e-02 | 21 |
GO:009887613 | Prostate | Tumor | vesicle-mediated transport to the plasma membrane | 42/3246 | 136/18723 | 7.47e-05 | 7.84e-04 | 42 |
GO:001619713 | Prostate | Tumor | endosomal transport | 62/3246 | 230/18723 | 1.65e-04 | 1.47e-03 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD50 | insertion | In_Frame_Ins | novel | c.1098_1099insGTTTCTTATTCACCAACAAAGTGGGGA | p.Ile366_Thr367insValSerTyrSerProThrLysTrpGly | p.I366_T367insVSYSPTKWG | Q9ULJ7 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
ANKRD50 | insertion | Nonsense_Mutation | novel | c.4134_4135insCCGTCGCAGGGAGCCCAAGCACATTTCTGCGCTGTCTAGTGCTGTCAGTAGAGTCTTAAAGT | p.Val1379ProfsTer13 | p.V1379Pfs*13 | Q9ULJ7 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
ANKRD50 | deletion | Frame_Shift_Del | novel | c.2969delN | p.Gly990AlafsTer9 | p.G990Afs*9 | Q9ULJ7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ANKRD50 | deletion | Frame_Shift_Del | novel | c.3215delN | p.Asn1072ThrfsTer22 | p.N1072Tfs*22 | Q9ULJ7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ANKRD50 | SNV | Missense_Mutation | c.3446N>T | p.Ser1149Leu | p.S1149L | Q9ULJ7 | protein_coding | tolerated(0.09) | benign(0.011) | TCGA-EK-A2H1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cetuximab | SD | |
ANKRD50 | SNV | Missense_Mutation | novel | c.3983G>A | p.Cys1328Tyr | p.C1328Y | Q9ULJ7 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD50 | SNV | Missense_Mutation | novel | c.2063G>A | p.Gly688Glu | p.G688E | Q9ULJ7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
ANKRD50 | SNV | Missense_Mutation | novel | c.163N>G | p.Met55Val | p.M55V | Q9ULJ7 | protein_coding | tolerated_low_confidence(0.26) | benign(0) | TCGA-VS-A9UY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ANKRD50 | SNV | Missense_Mutation | c.1703G>A | p.Gly568Glu | p.G568E | Q9ULJ7 | protein_coding | tolerated(0.15) | benign(0.41) | TCGA-A6-6652-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | cetuximab | SD | |
ANKRD50 | SNV | Missense_Mutation | c.997N>A | p.Leu333Ile | p.L333I | Q9ULJ7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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