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Gene: ANKH |
Gene summary for ANKH |
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Gene information | Species | Human | Gene symbol | ANKH | Gene ID | 56172 |
Gene name | ANKH inorganic pyrophosphate transport regulator | |
Gene Alias | ANK | |
Cytomap | 5p15.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q9HCJ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56172 | ANKH | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.58e-08 | 8.25e-01 | -0.0811 |
56172 | ANKH | HTA11_78_2000001011 | Human | Colorectum | AD | 2.10e-04 | 6.33e-01 | -0.1088 |
56172 | ANKH | HTA11_347_2000001011 | Human | Colorectum | AD | 1.62e-02 | 3.75e-01 | -0.1954 |
56172 | ANKH | HTA11_866_2000001011 | Human | Colorectum | AD | 1.34e-05 | 5.56e-01 | -0.1001 |
56172 | ANKH | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.05e-07 | 1.12e+00 | -0.059 |
56172 | ANKH | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.59e-02 | 7.07e-01 | 0.0131 |
56172 | ANKH | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.08e-02 | 6.33e-01 | 0.0338 |
56172 | ANKH | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.22e-03 | 7.16e-01 | 0.0112 |
56172 | ANKH | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.96e-10 | 9.35e-01 | 0.0588 |
56172 | ANKH | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.27e-04 | 9.19e-01 | 0.3487 |
56172 | ANKH | A001-C-207 | Human | Colorectum | FAP | 7.46e-04 | 1.29e-01 | 0.1278 |
56172 | ANKH | A015-C-203 | Human | Colorectum | FAP | 2.60e-28 | -1.75e-01 | -0.1294 |
56172 | ANKH | A015-C-204 | Human | Colorectum | FAP | 4.71e-06 | 1.31e-01 | -0.0228 |
56172 | ANKH | A014-C-040 | Human | Colorectum | FAP | 8.36e-05 | 3.99e-02 | -0.1184 |
56172 | ANKH | A002-C-201 | Human | Colorectum | FAP | 3.66e-16 | 1.75e-01 | 0.0324 |
56172 | ANKH | A002-C-203 | Human | Colorectum | FAP | 8.78e-08 | 3.25e-01 | 0.2786 |
56172 | ANKH | A001-C-119 | Human | Colorectum | FAP | 8.14e-05 | -2.11e-01 | -0.1557 |
56172 | ANKH | A001-C-108 | Human | Colorectum | FAP | 4.42e-15 | -1.17e-01 | -0.0272 |
56172 | ANKH | A002-C-205 | Human | Colorectum | FAP | 1.31e-22 | -1.63e-01 | -0.1236 |
56172 | ANKH | A015-C-005 | Human | Colorectum | FAP | 6.15e-09 | -3.68e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0001503 | Colorectum | AD | ossification | 106/3918 | 408/18723 | 7.68e-03 | 4.64e-02 | 106 |
GO:00015031 | Colorectum | SER | ossification | 82/2897 | 408/18723 | 6.76e-03 | 4.78e-02 | 82 |
GO:00015033 | Colorectum | FAP | ossification | 79/2622 | 408/18723 | 1.53e-03 | 1.37e-02 | 79 |
GO:0030278 | Colorectum | FAP | regulation of ossification | 27/2622 | 115/18723 | 4.23e-03 | 2.90e-02 | 27 |
GO:00156981 | Colorectum | FAP | inorganic anion transport | 38/2622 | 180/18723 | 5.73e-03 | 3.67e-02 | 38 |
GO:00015034 | Colorectum | CRC | ossification | 64/2078 | 408/18723 | 2.73e-03 | 2.49e-02 | 64 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:00015035 | Liver | Cirrhotic | ossification | 127/4634 | 408/18723 | 1.89e-03 | 1.19e-02 | 127 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
GO:000150315 | Oral cavity | LP | ossification | 123/4623 | 408/18723 | 6.55e-03 | 3.84e-02 | 123 |
GO:00015039 | Prostate | BPH | ossification | 107/3107 | 408/18723 | 4.31e-07 | 8.83e-06 | 107 |
GO:00302782 | Prostate | BPH | regulation of ossification | 29/3107 | 115/18723 | 1.18e-02 | 4.76e-02 | 29 |
GO:000150314 | Prostate | Tumor | ossification | 109/3246 | 408/18723 | 1.13e-06 | 2.14e-05 | 109 |
GO:003027811 | Prostate | Tumor | regulation of ossification | 32/3246 | 115/18723 | 3.39e-03 | 1.75e-02 | 32 |
GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
GO:00302785 | Thyroid | PTC | regulation of ossification | 51/5968 | 115/18723 | 3.30e-03 | 1.61e-02 | 51 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:003027813 | Thyroid | ATC | regulation of ossification | 60/6293 | 115/18723 | 3.01e-05 | 2.51e-04 | 60 |
GO:01101492 | Thyroid | ATC | regulation of biomineralization | 45/6293 | 99/18723 | 9.34e-03 | 3.44e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKH | SNV | Missense_Mutation | novel | c.1090N>A | p.Ala364Thr | p.A364T | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKH | SNV | Missense_Mutation | novel | c.610N>T | p.Arg204Cys | p.R204C | Q9HCJ1 | protein_coding | deleterious(0) | possibly_damaging(0.643) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKH | SNV | Missense_Mutation | rs768077784 | c.1343C>T | p.Ala448Val | p.A448V | Q9HCJ1 | protein_coding | tolerated(0.15) | benign(0.062) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ANKH | SNV | Missense_Mutation | rs753303788 | c.1394N>T | p.Thr465Met | p.T465M | Q9HCJ1 | protein_coding | tolerated_low_confidence(0.34) | benign(0.031) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANKH | SNV | Missense_Mutation | c.214N>A | p.Val72Met | p.V72M | Q9HCJ1 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKH | SNV | Missense_Mutation | novel | c.512N>A | p.Ala171Asp | p.A171D | Q9HCJ1 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKH | SNV | Missense_Mutation | c.368N>T | p.Ser123Leu | p.S123L | Q9HCJ1 | protein_coding | tolerated(0.06) | benign(0.314) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKH | SNV | Missense_Mutation | rs755062446 | c.1246N>A | p.Val416Met | p.V416M | Q9HCJ1 | protein_coding | deleterious(0.02) | benign(0.036) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ANKH | SNV | Missense_Mutation | novel | c.1219N>T | p.Arg407Trp | p.R407W | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ANKH | SNV | Missense_Mutation | rs763228863 | c.578N>T | p.Pro193Leu | p.P193L | Q9HCJ1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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