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Gene: ALKBH7 |
Gene summary for ALKBH7 |
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Gene information | Species | Human | Gene symbol | ALKBH7 | Gene ID | 84266 |
Gene name | alkB homolog 7 | |
Gene Alias | ABH7 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9BT30 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84266 | ALKBH7 | CA_HPV_1 | Human | Cervix | CC | 1.31e-07 | -3.82e-01 | 0.0264 |
84266 | ALKBH7 | CA_HPV_2 | Human | Cervix | CC | 9.02e-04 | -3.08e-01 | 0.0391 |
84266 | ALKBH7 | CA_HPV_3 | Human | Cervix | CC | 2.73e-02 | 8.79e-02 | 0.0414 |
84266 | ALKBH7 | N_HPV_2 | Human | Cervix | N_HPV | 1.20e-02 | -3.27e-02 | -0.0131 |
84266 | ALKBH7 | CCI_1 | Human | Cervix | CC | 3.04e-11 | -6.67e-01 | 0.528 |
84266 | ALKBH7 | CCI_2 | Human | Cervix | CC | 8.67e-08 | -6.45e-01 | 0.5249 |
84266 | ALKBH7 | CCI_3 | Human | Cervix | CC | 6.03e-15 | -6.67e-01 | 0.516 |
84266 | ALKBH7 | CCII_1 | Human | Cervix | CC | 1.35e-20 | -6.67e-01 | 0.3249 |
84266 | ALKBH7 | Tumor | Human | Cervix | CC | 1.30e-03 | -3.48e-01 | 0.1241 |
84266 | ALKBH7 | sample3 | Human | Cervix | CC | 9.98e-06 | -3.65e-01 | 0.1387 |
84266 | ALKBH7 | H2 | Human | Cervix | HSIL_HPV | 8.16e-04 | -3.40e-01 | 0.0632 |
84266 | ALKBH7 | L1 | Human | Cervix | CC | 3.83e-07 | -4.01e-01 | 0.0802 |
84266 | ALKBH7 | T3 | Human | Cervix | CC | 9.85e-11 | -3.78e-01 | 0.1389 |
84266 | ALKBH7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.28e-15 | 4.07e-01 | 0.0155 |
84266 | ALKBH7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.29e-35 | 9.10e-01 | -0.1808 |
84266 | ALKBH7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.86e-06 | 4.65e-01 | 0.0216 |
84266 | ALKBH7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.37e-22 | 6.58e-01 | -0.0811 |
84266 | ALKBH7 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.55e-05 | 2.62e-01 | -0.1088 |
84266 | ALKBH7 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.30e-49 | 8.74e-01 | -0.1954 |
84266 | ALKBH7 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.66e-14 | 1.24e+00 | -0.2602 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
GO:00070067 | Cervix | CC | mitochondrial membrane organization | 28/2311 | 116/18723 | 3.28e-04 | 3.47e-03 | 28 |
GO:00108834 | Cervix | CC | regulation of lipid storage | 15/2311 | 57/18723 | 3.13e-03 | 2.05e-02 | 15 |
GO:000683914 | Cervix | HSIL_HPV | mitochondrial transport | 22/737 | 254/18723 | 4.72e-04 | 6.90e-03 | 22 |
GO:005123514 | Cervix | HSIL_HPV | maintenance of location | 26/737 | 327/18723 | 5.67e-04 | 8.04e-03 | 26 |
GO:005123524 | Cervix | N_HPV | maintenance of location | 33/534 | 327/18723 | 3.40e-10 | 2.21e-07 | 33 |
GO:000683924 | Cervix | N_HPV | mitochondrial transport | 22/534 | 254/18723 | 4.05e-06 | 1.60e-04 | 22 |
GO:000700614 | Cervix | N_HPV | mitochondrial membrane organization | 9/534 | 116/18723 | 6.00e-03 | 4.17e-02 | 9 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0090559 | Colorectum | AD | regulation of membrane permeability | 31/3918 | 78/18723 | 1.16e-04 | 1.72e-03 | 31 |
GO:0046902 | Colorectum | AD | regulation of mitochondrial membrane permeability | 24/3918 | 63/18723 | 1.34e-03 | 1.17e-02 | 24 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:00070061 | Colorectum | SER | mitochondrial membrane organization | 38/2897 | 116/18723 | 2.66e-06 | 1.10e-04 | 38 |
GO:00469021 | Colorectum | SER | regulation of mitochondrial membrane permeability | 20/2897 | 63/18723 | 9.29e-04 | 1.12e-02 | 20 |
GO:00905591 | Colorectum | SER | regulation of membrane permeability | 23/2897 | 78/18723 | 1.25e-03 | 1.41e-02 | 23 |
GO:00066311 | Colorectum | SER | fatty acid metabolic process | 79/2897 | 390/18723 | 6.34e-03 | 4.56e-02 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALKBH7 | SNV | Missense_Mutation | novel | c.445N>A | p.Gln149Lys | p.Q149K | Q9BT30 | protein_coding | tolerated(0.78) | benign(0.096) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
ALKBH7 | SNV | Missense_Mutation | novel | c.632N>T | p.Pro211Leu | p.P211L | Q9BT30 | protein_coding | tolerated(0.13) | benign(0) | TCGA-RS-A6TP-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ALKBH7 | SNV | Missense_Mutation | c.227N>T | p.Thr76Ile | p.T76I | Q9BT30 | protein_coding | tolerated(0.09) | benign(0.159) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ALKBH7 | SNV | Missense_Mutation | rs769699986 | c.310N>T | p.Leu104Phe | p.L104F | Q9BT30 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ALKBH7 | deletion | Frame_Shift_Del | rs767513504 | c.656delC | p.Pro219GlnfsTer23 | p.P219Qfs*23 | Q9BT30 | protein_coding | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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