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Gene: ALKBH4 |
Gene summary for ALKBH4 |
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Gene information | Species | Human | Gene symbol | ALKBH4 | Gene ID | 54784 |
Gene name | alkB homolog 4, lysine demethylase | |
Gene Alias | ABH4 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q9NXW9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54784 | ALKBH4 | LZE4T | Human | Esophagus | ESCC | 2.31e-02 | 1.88e-01 | 0.0811 |
54784 | ALKBH4 | LZE7T | Human | Esophagus | ESCC | 7.06e-05 | 2.34e-01 | 0.0667 |
54784 | ALKBH4 | LZE24T | Human | Esophagus | ESCC | 1.74e-10 | 2.70e-01 | 0.0596 |
54784 | ALKBH4 | P1T-E | Human | Esophagus | ESCC | 9.55e-03 | 1.89e-01 | 0.0875 |
54784 | ALKBH4 | P2T-E | Human | Esophagus | ESCC | 5.65e-55 | 8.37e-01 | 0.1177 |
54784 | ALKBH4 | P4T-E | Human | Esophagus | ESCC | 1.84e-24 | 5.55e-01 | 0.1323 |
54784 | ALKBH4 | P5T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.61e-01 | 0.1327 |
54784 | ALKBH4 | P8T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.92e-01 | 0.0889 |
54784 | ALKBH4 | P9T-E | Human | Esophagus | ESCC | 3.84e-07 | 2.19e-01 | 0.1131 |
54784 | ALKBH4 | P10T-E | Human | Esophagus | ESCC | 7.34e-27 | 4.92e-01 | 0.116 |
54784 | ALKBH4 | P11T-E | Human | Esophagus | ESCC | 1.12e-11 | 4.26e-01 | 0.1426 |
54784 | ALKBH4 | P12T-E | Human | Esophagus | ESCC | 1.06e-41 | 6.32e-01 | 0.1122 |
54784 | ALKBH4 | P15T-E | Human | Esophagus | ESCC | 2.90e-29 | 6.22e-01 | 0.1149 |
54784 | ALKBH4 | P16T-E | Human | Esophagus | ESCC | 1.05e-38 | 6.01e-01 | 0.1153 |
54784 | ALKBH4 | P17T-E | Human | Esophagus | ESCC | 7.33e-10 | 4.81e-01 | 0.1278 |
54784 | ALKBH4 | P19T-E | Human | Esophagus | ESCC | 1.17e-02 | 2.99e-01 | 0.1662 |
54784 | ALKBH4 | P20T-E | Human | Esophagus | ESCC | 1.50e-33 | 6.69e-01 | 0.1124 |
54784 | ALKBH4 | P21T-E | Human | Esophagus | ESCC | 1.25e-26 | 4.92e-01 | 0.1617 |
54784 | ALKBH4 | P22T-E | Human | Esophagus | ESCC | 5.00e-17 | 2.80e-01 | 0.1236 |
54784 | ALKBH4 | P23T-E | Human | Esophagus | ESCC | 2.53e-27 | 5.89e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003250614 | Esophagus | ESCC | cytokinetic process | 35/8552 | 39/18723 | 9.38e-09 | 1.90e-07 | 35 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:00064824 | Esophagus | ESCC | protein demethylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00082144 | Esophagus | ESCC | protein dealkylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:003103219 | Esophagus | ESCC | actomyosin structure organization | 108/8552 | 196/18723 | 4.86e-03 | 1.88e-02 | 108 |
GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
GO:19022751 | Esophagus | ESCC | regulation of chromatin organization | 22/8552 | 33/18723 | 1.22e-02 | 4.08e-02 | 22 |
GO:003103212 | Liver | Cirrhotic | actomyosin structure organization | 74/4634 | 196/18723 | 3.39e-05 | 4.17e-04 | 74 |
GO:00325063 | Liver | Cirrhotic | cytokinetic process | 21/4634 | 39/18723 | 9.13e-05 | 9.74e-04 | 21 |
GO:00009105 | Liver | Cirrhotic | cytokinesis | 62/4634 | 173/18723 | 7.13e-04 | 5.33e-03 | 62 |
GO:00616402 | Liver | Cirrhotic | cytoskeleton-dependent cytokinesis | 38/4634 | 100/18723 | 2.22e-03 | 1.35e-02 | 38 |
GO:0070989 | Liver | Cirrhotic | oxidative demethylation | 10/4634 | 19/18723 | 8.23e-03 | 3.83e-02 | 10 |
GO:003250611 | Liver | HCC | cytokinetic process | 32/7958 | 39/18723 | 4.73e-07 | 7.69e-06 | 32 |
GO:000091011 | Liver | HCC | cytokinesis | 100/7958 | 173/18723 | 3.38e-05 | 3.39e-04 | 100 |
GO:003103222 | Liver | HCC | actomyosin structure organization | 109/7958 | 196/18723 | 1.39e-04 | 1.13e-03 | 109 |
GO:006164011 | Liver | HCC | cytoskeleton-dependent cytokinesis | 60/7958 | 100/18723 | 3.09e-04 | 2.20e-03 | 60 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:00325065 | Oral cavity | OSCC | cytokinetic process | 33/7305 | 39/18723 | 5.91e-09 | 1.26e-07 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALKBH4 | SNV | Missense_Mutation | novel | c.164N>T | p.Ala55Val | p.A55V | Q9NXW9 | protein_coding | deleterious(0.03) | benign(0.123) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ALKBH4 | SNV | Missense_Mutation | rs766828985 | c.409C>T | p.Arg137Trp | p.R137W | Q9NXW9 | protein_coding | deleterious(0.01) | benign(0.409) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ALKBH4 | SNV | Missense_Mutation | novel | c.753N>C | p.Gln251His | p.Q251H | Q9NXW9 | protein_coding | tolerated(0.19) | possibly_damaging(0.844) | TCGA-B5-A5OE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
ALKBH4 | SNV | Missense_Mutation | c.173C>A | p.Thr58Lys | p.T58K | Q9NXW9 | protein_coding | tolerated(0.92) | benign(0) | TCGA-D1-A160-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ALKBH4 | SNV | Missense_Mutation | rs141300734 | c.904N>A | p.Val302Met | p.V302M | Q9NXW9 | protein_coding | deleterious(0.04) | benign(0.044) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ALKBH4 | SNV | Missense_Mutation | rs771683787 | c.445N>T | p.Arg149Trp | p.R149W | Q9NXW9 | protein_coding | tolerated(0.09) | possibly_damaging(0.733) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ALKBH4 | SNV | Missense_Mutation | rs767584826 | c.745N>T | p.Arg249Trp | p.R249W | Q9NXW9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ALKBH4 | SNV | Missense_Mutation | novel | c.449N>T | p.Pro150Leu | p.P150L | Q9NXW9 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ALKBH4 | SNV | Missense_Mutation | rs754992172 | c.716N>A | p.Arg239His | p.R239H | Q9NXW9 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALKBH4 | SNV | Missense_Mutation | novel | c.494N>T | p.Ala165Val | p.A165V | Q9NXW9 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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