![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AIG1 |
Gene summary for AIG1 |
![]() |
Gene information | Species | Human | Gene symbol | AIG1 | Gene ID | 51390 |
Gene name | androgen induced 1 | |
Gene Alias | AIG-1 | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | Q9NVV5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51390 | AIG1 | LZE2T | Human | Esophagus | ESCC | 1.80e-04 | 5.42e-01 | 0.082 |
51390 | AIG1 | LZE4T | Human | Esophagus | ESCC | 9.03e-22 | 6.47e-01 | 0.0811 |
51390 | AIG1 | LZE5T | Human | Esophagus | ESCC | 8.59e-04 | 7.07e-01 | 0.0514 |
51390 | AIG1 | LZE7T | Human | Esophagus | ESCC | 6.88e-18 | 5.23e-01 | 0.0667 |
51390 | AIG1 | LZE8T | Human | Esophagus | ESCC | 3.96e-09 | 4.15e-01 | 0.067 |
51390 | AIG1 | LZE20T | Human | Esophagus | ESCC | 2.78e-02 | 2.22e-01 | 0.0662 |
51390 | AIG1 | LZE22T | Human | Esophagus | ESCC | 3.87e-06 | 4.28e-01 | 0.068 |
51390 | AIG1 | LZE24T | Human | Esophagus | ESCC | 1.93e-24 | 6.87e-01 | 0.0596 |
51390 | AIG1 | LZE21T | Human | Esophagus | ESCC | 7.28e-09 | 5.82e-01 | 0.0655 |
51390 | AIG1 | LZE6T | Human | Esophagus | ESCC | 2.09e-10 | 8.44e-01 | 0.0845 |
51390 | AIG1 | P1T-E | Human | Esophagus | ESCC | 1.15e-07 | 5.04e-01 | 0.0875 |
51390 | AIG1 | P2T-E | Human | Esophagus | ESCC | 1.83e-24 | 3.68e-01 | 0.1177 |
51390 | AIG1 | P4T-E | Human | Esophagus | ESCC | 4.13e-53 | 1.06e+00 | 0.1323 |
51390 | AIG1 | P5T-E | Human | Esophagus | ESCC | 1.31e-50 | 9.18e-01 | 0.1327 |
51390 | AIG1 | P8T-E | Human | Esophagus | ESCC | 5.29e-47 | 8.78e-01 | 0.0889 |
51390 | AIG1 | P9T-E | Human | Esophagus | ESCC | 1.68e-20 | 5.36e-01 | 0.1131 |
51390 | AIG1 | P10T-E | Human | Esophagus | ESCC | 3.74e-23 | 4.48e-01 | 0.116 |
51390 | AIG1 | P11T-E | Human | Esophagus | ESCC | 1.44e-15 | 8.01e-01 | 0.1426 |
51390 | AIG1 | P12T-E | Human | Esophagus | ESCC | 2.66e-26 | 5.49e-01 | 0.1122 |
51390 | AIG1 | P15T-E | Human | Esophagus | ESCC | 3.70e-40 | 8.04e-01 | 0.1149 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00090628 | Esophagus | ESCC | fatty acid catabolic process | 66/8552 | 100/18723 | 3.21e-05 | 2.66e-04 | 66 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:00723297 | Esophagus | ESCC | monocarboxylic acid catabolic process | 74/8552 | 122/18723 | 6.03e-04 | 3.27e-03 | 74 |
GO:00442427 | Esophagus | ESCC | cellular lipid catabolic process | 121/8552 | 214/18723 | 8.63e-04 | 4.43e-03 | 121 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:00160427 | Esophagus | ESCC | lipid catabolic process | 168/8552 | 320/18723 | 7.97e-03 | 2.84e-02 | 168 |
GO:00463953 | Liver | NAFLD | carboxylic acid catabolic process | 73/1882 | 236/18723 | 4.16e-19 | 1.22e-15 | 73 |
GO:00160544 | Liver | NAFLD | organic acid catabolic process | 73/1882 | 240/18723 | 1.20e-18 | 2.34e-15 | 73 |
GO:00442825 | Liver | NAFLD | small molecule catabolic process | 91/1882 | 376/18723 | 8.96e-16 | 1.31e-12 | 91 |
GO:00066316 | Liver | NAFLD | fatty acid metabolic process | 92/1882 | 390/18723 | 3.38e-15 | 3.29e-12 | 92 |
GO:00723295 | Liver | NAFLD | monocarboxylic acid catabolic process | 39/1882 | 122/18723 | 2.40e-11 | 8.77e-09 | 39 |
GO:00090626 | Liver | NAFLD | fatty acid catabolic process | 34/1882 | 100/18723 | 6.81e-11 | 1.99e-08 | 34 |
GO:00442425 | Liver | NAFLD | cellular lipid catabolic process | 52/1882 | 214/18723 | 1.15e-09 | 2.17e-07 | 52 |
GO:00160426 | Liver | NAFLD | lipid catabolic process | 63/1882 | 320/18723 | 1.35e-07 | 1.02e-05 | 63 |
GO:00016763 | Liver | NAFLD | long-chain fatty acid metabolic process | 23/1882 | 112/18723 | 6.73e-04 | 8.66e-03 | 23 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:004428211 | Liver | Cirrhotic | small molecule catabolic process | 151/4634 | 376/18723 | 2.20e-11 | 1.34e-09 | 151 |
GO:001605411 | Liver | Cirrhotic | organic acid catabolic process | 104/4634 | 240/18723 | 1.91e-10 | 9.53e-09 | 104 |
GO:004639511 | Liver | Cirrhotic | carboxylic acid catabolic process | 102/4634 | 236/18723 | 3.41e-10 | 1.63e-08 | 102 |
GO:007232911 | Liver | Cirrhotic | monocarboxylic acid catabolic process | 56/4634 | 122/18723 | 2.87e-07 | 7.01e-06 | 56 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AIG1 | SNV | Missense_Mutation | novel | c.380N>A | p.Gly127Glu | p.G127E | Q9NVV5 | protein_coding | tolerated(0.95) | benign(0.037) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
AIG1 | SNV | Missense_Mutation | novel | c.597N>A | p.Phe199Leu | p.F199L | Q9NVV5 | protein_coding | tolerated(0.11) | probably_damaging(0.997) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AIG1 | insertion | Nonsense_Mutation | novel | c.667_668insTGACTTTAAAGGAGATTGGTTACATTTAATAATGTATCT | p.Asp223delinsValThrLeuLysGluIleGlyTyrIleTerTerCysIleTyr | p.D223delinsVTLKEIGYI**CIY | Q9NVV5 | protein_coding | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AIG1 | SNV | Missense_Mutation | c.239N>C | p.Lys80Thr | p.K80T | Q9NVV5 | protein_coding | tolerated(0.09) | benign(0.023) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AIG1 | SNV | Missense_Mutation | c.674N>T | p.Gln225Leu | p.Q225L | Q9NVV5 | protein_coding | tolerated(0.33) | benign(0.007) | TCGA-99-8028-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AIG1 | SNV | Missense_Mutation | novel | c.491C>T | p.Thr164Ile | p.T164I | Q9NVV5 | protein_coding | tolerated(0.54) | benign(0.007) | TCGA-H7-7774-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
AIG1 | SNV | Missense_Mutation | rs114392595 | c.490N>G | p.Thr164Ala | p.T164A | Q9NVV5 | protein_coding | tolerated(0.55) | benign(0) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
AIG1 | SNV | Missense_Mutation | novel | c.503N>C | p.Gly168Ala | p.G168A | Q9NVV5 | protein_coding | tolerated(1) | benign(0.009) | TCGA-RD-A7C1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |