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Gene: AGPAT2 |
Gene summary for AGPAT2 |
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Gene information | Species | Human | Gene symbol | AGPAT2 | Gene ID | 10555 |
Gene name | 1-acylglycerol-3-phosphate O-acyltransferase 2 | |
Gene Alias | 1-AGPAT2 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | A0A024R8F9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10555 | AGPAT2 | GSM4909281 | Human | Breast | IDC | 7.37e-09 | 3.21e-01 | 0.21 |
10555 | AGPAT2 | GSM4909285 | Human | Breast | IDC | 8.90e-06 | 2.23e-01 | 0.21 |
10555 | AGPAT2 | GSM4909291 | Human | Breast | IDC | 2.87e-09 | 4.48e-01 | 0.1753 |
10555 | AGPAT2 | GSM4909295 | Human | Breast | IDC | 1.51e-09 | 5.34e-01 | 0.0898 |
10555 | AGPAT2 | GSM4909296 | Human | Breast | IDC | 1.29e-02 | 1.17e-01 | 0.1524 |
10555 | AGPAT2 | GSM4909308 | Human | Breast | IDC | 6.38e-07 | 2.89e-01 | 0.158 |
10555 | AGPAT2 | GSM4909311 | Human | Breast | IDC | 5.06e-03 | 2.28e-02 | 0.1534 |
10555 | AGPAT2 | GSM4909317 | Human | Breast | IDC | 2.90e-18 | 5.15e-01 | 0.1355 |
10555 | AGPAT2 | GSM4909319 | Human | Breast | IDC | 3.60e-05 | -8.05e-02 | 0.1563 |
10555 | AGPAT2 | brca1 | Human | Breast | Precancer | 3.60e-05 | 3.38e-01 | -0.0338 |
10555 | AGPAT2 | brca2 | Human | Breast | Precancer | 9.10e-13 | 2.95e-01 | -0.024 |
10555 | AGPAT2 | brca3 | Human | Breast | Precancer | 6.08e-12 | 3.15e-01 | -0.0263 |
10555 | AGPAT2 | DCIS2 | Human | Breast | DCIS | 6.80e-30 | 1.37e-01 | 0.0085 |
10555 | AGPAT2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.82e-20 | 9.74e-01 | -0.1808 |
10555 | AGPAT2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.81e-14 | 6.04e-01 | -0.0811 |
10555 | AGPAT2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.68e-02 | 2.77e-01 | -0.1088 |
10555 | AGPAT2 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.36e-21 | 6.78e-01 | -0.1954 |
10555 | AGPAT2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.08e-07 | 1.53e+00 | -0.2602 |
10555 | AGPAT2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.98e-12 | 1.42e+00 | -0.2196 |
10555 | AGPAT2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.09e-05 | 4.78e-01 | -0.1207 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018196 | Breast | Precancer | positive regulation of cytokine production | 52/1080 | 467/18723 | 4.18e-06 | 1.29e-04 | 52 |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00094108 | Breast | Precancer | response to xenobiotic stimulus | 45/1080 | 462/18723 | 4.17e-04 | 5.56e-03 | 45 |
GO:000941013 | Breast | IDC | response to xenobiotic stimulus | 62/1434 | 462/18723 | 1.05e-05 | 2.88e-04 | 62 |
GO:000181911 | Breast | IDC | positive regulation of cytokine production | 61/1434 | 467/18723 | 2.81e-05 | 6.58e-04 | 61 |
GO:000854412 | Breast | IDC | epidermis development | 41/1434 | 324/18723 | 1.03e-03 | 1.14e-02 | 41 |
GO:000181921 | Breast | DCIS | positive regulation of cytokine production | 63/1390 | 467/18723 | 2.76e-06 | 9.42e-05 | 63 |
GO:000941023 | Breast | DCIS | response to xenobiotic stimulus | 59/1390 | 462/18723 | 3.00e-05 | 6.61e-04 | 59 |
GO:000854422 | Breast | DCIS | epidermis development | 40/1390 | 324/18723 | 1.05e-03 | 1.16e-02 | 40 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:00094101 | Colorectum | MSS | response to xenobiotic stimulus | 110/3467 | 462/18723 | 2.36e-03 | 1.92e-02 | 110 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00561 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa005611 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa005615 | Liver | HCC | Glycerolipid metabolism | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa0056112 | Liver | HCC | Glycerolipid metabolism | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGPAT2 | deletion | Frame_Shift_Del | novel | c.552delT | p.Phe184LeufsTer69 | p.F184Lfs*69 | O15120 | protein_coding | TCGA-38-4628-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
AGPAT2 | deletion | In_Frame_Del | c.242_259delNNNNNNNNNNNNNNNNNN | p.Arg81_Leu86del | p.R81_L86del | O15120 | protein_coding | TCGA-55-8615-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | |||
AGPAT2 | SNV | Missense_Mutation | rs759115310 | c.410G>A | p.Gly137Asp | p.G137D | O15120 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-CN-5369-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AGPAT2 | SNV | Missense_Mutation | c.210C>A | p.Phe70Leu | p.F70L | O15120 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
AGPAT2 | SNV | Missense_Mutation | c.107N>A | p.Leu36Gln | p.L36Q | O15120 | protein_coding | deleterious(0.01) | possibly_damaging(0.62) | TCGA-G9-6363-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
AGPAT2 | SNV | Missense_Mutation | rs755548321 | c.251N>A | p.Arg84His | p.R84H | O15120 | protein_coding | tolerated(0.13) | benign(0) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
AGPAT2 | SNV | Missense_Mutation | novel | c.437C>G | p.Ser146Cys | p.S146C | O15120 | protein_coding | deleterious(0.02) | possibly_damaging(0.84) | TCGA-EL-A4K7-01 | Thyroid | thyroid carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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