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Gene: ADD3 |
Gene summary for ADD3 |
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Gene information | Species | Human | Gene symbol | ADD3 | Gene ID | 120 |
Gene name | adducin 3 | |
Gene Alias | ADDL | |
Cytomap | 10q25.1-q25.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9UEY8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
120 | ADD3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.18e-02 | -2.84e-01 | 0.0155 |
120 | ADD3 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.51e-15 | 7.65e-01 | -0.1954 |
120 | ADD3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.56e-03 | -4.78e-02 | 0.0446 |
120 | ADD3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.74e-15 | 1.01e+00 | 0.281 |
120 | ADD3 | A015-C-203 | Human | Colorectum | FAP | 1.98e-28 | -3.57e-01 | -0.1294 |
120 | ADD3 | A014-C-040 | Human | Colorectum | FAP | 2.68e-02 | -2.15e-01 | -0.1184 |
120 | ADD3 | A002-C-201 | Human | Colorectum | FAP | 4.32e-08 | -2.94e-01 | 0.0324 |
120 | ADD3 | A002-C-203 | Human | Colorectum | FAP | 4.58e-02 | -2.08e-02 | 0.2786 |
120 | ADD3 | A001-C-119 | Human | Colorectum | FAP | 1.03e-02 | -1.56e-01 | -0.1557 |
120 | ADD3 | A001-C-108 | Human | Colorectum | FAP | 2.61e-14 | -6.26e-02 | -0.0272 |
120 | ADD3 | A002-C-205 | Human | Colorectum | FAP | 2.73e-18 | -1.67e-01 | -0.1236 |
120 | ADD3 | A015-C-005 | Human | Colorectum | FAP | 1.64e-03 | -2.94e-01 | -0.0336 |
120 | ADD3 | A015-C-006 | Human | Colorectum | FAP | 3.15e-12 | -3.85e-01 | -0.0994 |
120 | ADD3 | A015-C-106 | Human | Colorectum | FAP | 3.17e-09 | -1.76e-01 | -0.0511 |
120 | ADD3 | A002-C-114 | Human | Colorectum | FAP | 3.66e-18 | -4.67e-01 | -0.1561 |
120 | ADD3 | A015-C-104 | Human | Colorectum | FAP | 3.52e-36 | -3.34e-01 | -0.1899 |
120 | ADD3 | A001-C-014 | Human | Colorectum | FAP | 6.88e-15 | -1.93e-01 | 0.0135 |
120 | ADD3 | A002-C-016 | Human | Colorectum | FAP | 2.39e-21 | -1.85e-01 | 0.0521 |
120 | ADD3 | A015-C-002 | Human | Colorectum | FAP | 8.36e-12 | -5.50e-01 | -0.0763 |
120 | ADD3 | A001-C-203 | Human | Colorectum | FAP | 1.01e-08 | -1.23e-01 | -0.0481 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0032272 | Colorectum | AD | negative regulation of protein polymerization | 36/3918 | 80/18723 | 1.13e-06 | 3.72e-05 | 36 |
GO:0030837 | Colorectum | AD | negative regulation of actin filament polymerization | 30/3918 | 65/18723 | 4.59e-06 | 1.22e-04 | 30 |
GO:1902904 | Colorectum | AD | negative regulation of supramolecular fiber organization | 60/3918 | 167/18723 | 5.23e-06 | 1.35e-04 | 60 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADD3 | SNV | Missense_Mutation | rs563431160 | c.1049C>T | p.Ala350Val | p.A350V | Q9UEY8 | protein_coding | tolerated(0.21) | benign(0.006) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
ADD3 | SNV | Missense_Mutation | c.134N>C | p.Leu45Pro | p.L45P | Q9UEY8 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ADD3 | SNV | Missense_Mutation | novel | c.407T>G | p.Leu136Arg | p.L136R | Q9UEY8 | protein_coding | deleterious(0) | benign(0.218) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADD3 | SNV | Missense_Mutation | c.368N>A | p.Pro123His | p.P123H | Q9UEY8 | protein_coding | tolerated(0.93) | benign(0.003) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADD3 | SNV | Missense_Mutation | rs374723508 | c.1252N>A | p.Asp418Asn | p.D418N | Q9UEY8 | protein_coding | deleterious(0.01) | possibly_damaging(0.484) | TCGA-QG-A5Z1-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ADD3 | SNV | Missense_Mutation | c.1723G>A | p.Gly575Ser | p.G575S | Q9UEY8 | protein_coding | deleterious(0.04) | benign(0.08) | TCGA-DC-6154-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
ADD3 | SNV | Missense_Mutation | novel | c.1743N>T | p.Gln581His | p.Q581H | Q9UEY8 | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADD3 | SNV | Missense_Mutation | novel | c.946N>A | p.Ala316Thr | p.A316T | Q9UEY8 | protein_coding | deleterious(0.01) | possibly_damaging(0.886) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ADD3 | SNV | Missense_Mutation | novel | c.1039N>G | p.Thr347Ala | p.T347A | Q9UEY8 | protein_coding | tolerated(0.75) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ADD3 | SNV | Missense_Mutation | c.94G>A | p.Asp32Asn | p.D32N | Q9UEY8 | protein_coding | tolerated(0.2) | probably_damaging(0.948) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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