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Gene: ADAMTS14 |
Gene summary for ADAMTS14 |
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Gene information | Species | Human | Gene symbol | ADAMTS14 | Gene ID | 140766 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 14 | |
Gene Alias | ADAMTS14 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8WXS8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140766 | ADAMTS14 | ATC11 | Human | Thyroid | ATC | 2.49e-06 | 4.38e-01 | 0.3386 |
140766 | ADAMTS14 | ATC12 | Human | Thyroid | ATC | 1.28e-08 | 2.78e-01 | 0.34 |
140766 | ADAMTS14 | ATC13 | Human | Thyroid | ATC | 5.13e-22 | 4.36e-01 | 0.34 |
140766 | ADAMTS14 | ATC2 | Human | Thyroid | ATC | 1.80e-12 | 6.90e-01 | 0.34 |
140766 | ADAMTS14 | ATC3 | Human | Thyroid | ATC | 1.86e-15 | 7.30e-01 | 0.338 |
140766 | ADAMTS14 | ATC4 | Human | Thyroid | ATC | 2.71e-11 | 3.34e-01 | 0.34 |
140766 | ADAMTS14 | ATC5 | Human | Thyroid | ATC | 1.14e-29 | 4.70e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:003019911 | Thyroid | ATC | collagen fibril organization | 43/6293 | 61/18723 | 4.24e-09 | 9.57e-08 | 43 |
GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS14 | insertion | Nonsense_Mutation | novel | c.2542_2543insGTGAGGAGAGATAAAGACAGTTGTCTCCTCACTGTC | p.Glu848delinsGlyGluGluArgTerArgGlnLeuSerProHisCysGln | p.E848delinsGEER*RQLSPHCQ | Q8WXS8 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
ADAMTS14 | insertion | Frame_Shift_Ins | novel | c.2696_2697insTTCTTACCAGCGAGATGGAGCTGAT | p.Ile900SerfsTer70 | p.I900Sfs*70 | Q8WXS8 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
ADAMTS14 | insertion | In_Frame_Ins | novel | c.925_926insCGTTGGACTATGGTCATT | p.Val309delinsAlaLeuAspTyrGlyHisPhe | p.V309delinsALDYGHF | Q8WXS8 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
ADAMTS14 | SNV | Missense_Mutation | c.676N>A | p.Glu226Lys | p.E226K | Q8WXS8 | protein_coding | tolerated(0.2) | benign(0.022) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
ADAMTS14 | SNV | Missense_Mutation | novel | c.2686A>T | p.Arg896Trp | p.R896W | Q8WXS8 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
ADAMTS14 | SNV | Missense_Mutation | rs746772566 | c.2054G>A | p.Arg685His | p.R685H | Q8WXS8 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ADAMTS14 | SNV | Missense_Mutation | c.3418N>A | p.Pro1140Thr | p.P1140T | Q8WXS8 | protein_coding | tolerated(0.27) | benign(0.015) | TCGA-EK-A2RB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAMTS14 | SNV | Missense_Mutation | rs750022384 | c.2488N>A | p.Val830Ile | p.V830I | Q8WXS8 | protein_coding | tolerated(1) | benign(0.01) | TCGA-Q1-A5R3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
ADAMTS14 | SNV | Missense_Mutation | rs777171630 | c.1369N>A | p.Asp457Asn | p.D457N | Q8WXS8 | protein_coding | deleterious(0.03) | benign(0.036) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ADAMTS14 | insertion | Frame_Shift_Ins | novel | c.2685dupG | p.Arg896GlufsTer66 | p.R896Efs*66 | Q8WXS8 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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