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Gene: ACSS3 |
Gene summary for ACSS3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ACSS3 | Gene ID | 79611 |
Gene name | acyl-CoA synthetase short chain family member 3 | |
Gene Alias | ACSS3 | |
Cytomap | 12q21.31 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | A0A0B4J1R2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79611 | ACSS3 | NAFLD1 | Human | Liver | NAFLD | 1.09e-14 | 1.07e+00 | -0.04 |
79611 | ACSS3 | S41 | Human | Liver | Cirrhotic | 4.06e-02 | 4.94e-01 | -0.0343 |
79611 | ACSS3 | S43 | Human | Liver | Cirrhotic | 7.07e-04 | 9.03e-02 | -0.0187 |
79611 | ACSS3 | HCC1_Meng | Human | Liver | HCC | 2.80e-79 | 2.03e-01 | 0.0246 |
79611 | ACSS3 | HCC2_Meng | Human | Liver | HCC | 4.93e-06 | -1.59e-01 | 0.0107 |
79611 | ACSS3 | Pt13.b | Human | Liver | HCC | 6.85e-03 | 7.91e-02 | 0.0251 |
79611 | ACSS3 | S014 | Human | Liver | HCC | 1.96e-17 | 1.08e+00 | 0.2254 |
79611 | ACSS3 | S015 | Human | Liver | HCC | 4.41e-06 | 8.09e-01 | 0.2375 |
79611 | ACSS3 | S016 | Human | Liver | HCC | 7.98e-28 | 1.20e+00 | 0.2243 |
79611 | ACSS3 | S029 | Human | Liver | HCC | 2.17e-05 | 4.23e-01 | 0.2581 |
79611 | ACSS3 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.23e-02 | 5.45e-01 | -0.1406 |
79611 | ACSS3 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 4.15e-05 | 7.38e-01 | -0.1408 |
79611 | ACSS3 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 7.77e-05 | 7.50e-01 | -0.138 |
79611 | ACSS3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 8.30e-15 | 8.62e-01 | -0.2116 |
79611 | ACSS3 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.44e-07 | 8.89e-01 | -0.1941 |
79611 | ACSS3 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.10e-04 | 7.01e-01 | -0.2107 |
79611 | ACSS3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.29e-19 | 1.03e+00 | -0.2119 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00060917 | Liver | NAFLD | generation of precursor metabolites and energy | 84/1882 | 490/18723 | 7.03e-07 | 3.95e-05 | 84 |
GO:1902224 | Liver | NAFLD | ketone body metabolic process | 5/1882 | 10/18723 | 1.67e-03 | 1.74e-02 | 5 |
GO:000609112 | Liver | Cirrhotic | generation of precursor metabolites and energy | 238/4634 | 490/18723 | 6.85e-31 | 1.07e-27 | 238 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:1901568 | Liver | HCC | fatty acid derivative metabolic process | 43/7958 | 74/18723 | 4.85e-03 | 2.04e-02 | 43 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0064010 | Liver | NAFLD | Propanoate metabolism | 12/1043 | 32/8465 | 2.44e-04 | 4.45e-03 | 3.58e-03 | 12 |
hsa0064011 | Liver | NAFLD | Propanoate metabolism | 12/1043 | 32/8465 | 2.44e-04 | 4.45e-03 | 3.58e-03 | 12 |
hsa0064041 | Liver | HCC | Propanoate metabolism | 24/4020 | 32/8465 | 1.42e-03 | 5.07e-03 | 2.82e-03 | 24 |
hsa0064051 | Liver | HCC | Propanoate metabolism | 24/4020 | 32/8465 | 1.42e-03 | 5.07e-03 | 2.82e-03 | 24 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACSS3 | SNV | Missense_Mutation | rs182895257 | c.1741N>A | p.Val581Met | p.V581M | Q9H6R3 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACSS3 | SNV | Missense_Mutation | c.364G>C | p.Glu122Gln | p.E122Q | Q9H6R3 | protein_coding | tolerated(0.07) | possibly_damaging(0.572) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ACSS3 | insertion | Nonsense_Mutation | novel | c.1697_1698insGTAATAGAAATGGA | p.Ile566MetfsTer2 | p.I566Mfs*2 | Q9H6R3 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
ACSS3 | SNV | Missense_Mutation | novel | c.1894G>C | p.Ala632Pro | p.A632P | Q9H6R3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ACSS3 | SNV | Missense_Mutation | c.1013C>A | p.Ala338Glu | p.A338E | Q9H6R3 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ACSS3 | SNV | Missense_Mutation | c.626N>T | p.Ser209Ile | p.S209I | Q9H6R3 | protein_coding | tolerated(0.16) | benign(0.022) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ACSS3 | SNV | Missense_Mutation | novel | c.586N>C | p.Ser196Arg | p.S196R | Q9H6R3 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ACSS3 | SNV | Missense_Mutation | novel | c.527N>T | p.Pro176Leu | p.P176L | Q9H6R3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACSS3 | SNV | Missense_Mutation | novel | c.757N>A | p.Leu253Ile | p.L253I | Q9H6R3 | protein_coding | tolerated(1) | benign(0.067) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACSS3 | SNV | Missense_Mutation | c.902N>A | p.Gly301Asp | p.G301D | Q9H6R3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
79611 | ACSS3 | NA | antidepressants | 25916525 |
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