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Gene: ACSS2 |
Gene summary for ACSS2 |
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Gene information | Species | Human | Gene symbol | ACSS2 | Gene ID | 55902 |
Gene name | acyl-CoA synthetase short chain family member 2 | |
Gene Alias | ACAS2 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | Q96FY7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55902 | ACSS2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.03e-13 | -5.46e-01 | 0.0155 |
55902 | ACSS2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.26e-06 | 5.80e-01 | -0.1808 |
55902 | ACSS2 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.41e-33 | 1.16e+00 | -0.1954 |
55902 | ACSS2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.04e-11 | 1.09e+00 | -0.2602 |
55902 | ACSS2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.95e-03 | 8.58e-01 | -0.2196 |
55902 | ACSS2 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.83e-03 | 4.84e-01 | -0.1526 |
55902 | ACSS2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.11e-06 | 6.15e-01 | -0.1464 |
55902 | ACSS2 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.01e-02 | 4.77e-01 | -0.1001 |
55902 | ACSS2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.74e-07 | -4.54e-01 | 0.096 |
55902 | ACSS2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.04e-03 | -4.67e-01 | 0.0338 |
55902 | ACSS2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.02e-19 | -6.14e-01 | 0.0674 |
55902 | ACSS2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.59e-07 | -6.93e-01 | 0.0588 |
55902 | ACSS2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.13e-10 | -5.32e-01 | 0.294 |
55902 | ACSS2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.01e-02 | -5.22e-01 | 0.2585 |
55902 | ACSS2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.69e-11 | -5.16e-01 | 0.3005 |
55902 | ACSS2 | F007 | Human | Colorectum | FAP | 3.66e-12 | -6.76e-01 | 0.1176 |
55902 | ACSS2 | A002-C-010 | Human | Colorectum | FAP | 9.32e-17 | -6.04e-01 | 0.242 |
55902 | ACSS2 | A001-C-207 | Human | Colorectum | FAP | 6.54e-10 | -5.41e-01 | 0.1278 |
55902 | ACSS2 | A015-C-203 | Human | Colorectum | FAP | 3.23e-33 | -5.83e-01 | -0.1294 |
55902 | ACSS2 | A015-C-204 | Human | Colorectum | FAP | 3.24e-06 | -3.28e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0009152 | Colorectum | AD | purine ribonucleotide biosynthetic process | 64/3918 | 169/18723 | 3.09e-07 | 1.22e-05 | 64 |
GO:0009260 | Colorectum | AD | ribonucleotide biosynthetic process | 66/3918 | 182/18723 | 1.25e-06 | 4.02e-05 | 66 |
GO:0046390 | Colorectum | AD | ribose phosphate biosynthetic process | 67/3918 | 190/18723 | 3.21e-06 | 9.05e-05 | 67 |
GO:0006164 | Colorectum | AD | purine nucleotide biosynthetic process | 66/3918 | 191/18723 | 8.22e-06 | 1.97e-04 | 66 |
GO:0072522 | Colorectum | AD | purine-containing compound biosynthetic process | 68/3918 | 200/18723 | 1.12e-05 | 2.55e-04 | 68 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:1901293 | Colorectum | AD | nucleoside phosphate biosynthetic process | 80/3918 | 256/18723 | 6.31e-05 | 1.05e-03 | 80 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0009165 | Colorectum | AD | nucleotide biosynthetic process | 79/3918 | 254/18723 | 8.33e-05 | 1.30e-03 | 79 |
GO:0033865 | Colorectum | AD | nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
GO:0033875 | Colorectum | AD | ribonucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00640 | Colorectum | AD | Propanoate metabolism | 18/2092 | 32/8465 | 1.33e-04 | 1.11e-03 | 7.08e-04 | 18 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa006401 | Colorectum | AD | Propanoate metabolism | 18/2092 | 32/8465 | 1.33e-04 | 1.11e-03 | 7.08e-04 | 18 |
hsa012002 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa006402 | Colorectum | SER | Propanoate metabolism | 13/1580 | 32/8465 | 3.20e-03 | 2.12e-02 | 1.54e-02 | 13 |
hsa012003 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa006403 | Colorectum | SER | Propanoate metabolism | 13/1580 | 32/8465 | 3.20e-03 | 2.12e-02 | 1.54e-02 | 13 |
hsa006204 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa012004 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa006404 | Colorectum | MSS | Propanoate metabolism | 15/1875 | 32/8465 | 1.68e-03 | 9.05e-03 | 5.55e-03 | 15 |
hsa006205 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa012005 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa006405 | Colorectum | MSS | Propanoate metabolism | 15/1875 | 32/8465 | 1.68e-03 | 9.05e-03 | 5.55e-03 | 15 |
hsa006406 | Colorectum | FAP | Propanoate metabolism | 15/1404 | 32/8465 | 6.21e-05 | 6.10e-04 | 3.71e-04 | 15 |
hsa006206 | Colorectum | FAP | Pyruvate metabolism | 17/1404 | 47/8465 | 9.18e-04 | 5.20e-03 | 3.16e-03 | 17 |
hsa006407 | Colorectum | FAP | Propanoate metabolism | 15/1404 | 32/8465 | 6.21e-05 | 6.10e-04 | 3.71e-04 | 15 |
hsa006207 | Colorectum | FAP | Pyruvate metabolism | 17/1404 | 47/8465 | 9.18e-04 | 5.20e-03 | 3.16e-03 | 17 |
hsa012008 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa006408 | Colorectum | CRC | Propanoate metabolism | 11/1091 | 32/8465 | 1.51e-03 | 1.17e-02 | 7.94e-03 | 11 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACSS2 | SNV | Missense_Mutation | novel | c.454N>A | p.Leu152Ile | p.L152I | Q9NR19 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ACSS2 | SNV | Missense_Mutation | c.427G>A | p.Val143Ile | p.V143I | Q9NR19 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-CA-6719-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ACSS2 | SNV | Missense_Mutation | c.1652N>G | p.Thr551Arg | p.T551R | Q9NR19 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ACSS2 | SNV | Missense_Mutation | novel | c.1502C>A | p.Ser501Tyr | p.S501Y | Q9NR19 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACSS2 | deletion | Frame_Shift_Del | c.391delN | p.Glu132ArgfsTer38 | p.E132Rfs*38 | Q9NR19 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
ACSS2 | deletion | Frame_Shift_Del | c.1592_1599delNNNNNNNN | p.Phe531SerfsTer17 | p.F531Sfs*17 | Q9NR19 | protein_coding | TCGA-AA-3844-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |||
ACSS2 | deletion | In_Frame_Del | c.1433_1435delTCT | p.Phe478del | p.F478del | Q9NR19 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |||
ACSS2 | deletion | Frame_Shift_Del | rs756048003 | c.806delC | p.Pro269GlnfsTer13 | p.P269Qfs*13 | Q9NR19 | protein_coding | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ACSS2 | SNV | Missense_Mutation | novel | c.1305N>T | p.Glu435Asp | p.E435D | Q9NR19 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACSS2 | SNV | Missense_Mutation | novel | c.1529N>T | p.Ala510Val | p.A510V | Q9NR19 | protein_coding | tolerated(0.67) | benign(0.006) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55902 | ACSS2 | ENZYME, TRANSCRIPTION FACTOR | docetaxel | DOCETAXEL | 21636554 | |
55902 | ACSS2 | ENZYME, TRANSCRIPTION FACTOR | inhibitor | 405560508 | ||
55902 | ACSS2 | ENZYME, TRANSCRIPTION FACTOR | paclitaxel | PACLITAXEL | 21636554 | |
55902 | ACSS2 | ENZYME, TRANSCRIPTION FACTOR | gemcitabine | GEMCITABINE | 21636554 | |
55902 | ACSS2 | ENZYME, TRANSCRIPTION FACTOR | ethanol | ALCOHOL | 28550509 | |
55902 | ACSS2 | ENZYME, TRANSCRIPTION FACTOR | cisplatin | CISPLATIN | 21636554 | |
55902 | ACSS2 | ENZYME, TRANSCRIPTION FACTOR | carboplatin | CARBOPLATIN | 21636554 |
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