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Gene: ACSF2 |
Gene summary for ACSF2 |
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Gene information | Species | Human | Gene symbol | ACSF2 | Gene ID | 80221 |
Gene name | acyl-CoA synthetase family member 2 | |
Gene Alias | ACSMW | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | Q96CM8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80221 | ACSF2 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.21e-09 | 4.46e-01 | -0.1954 |
80221 | ACSF2 | A015-C-203 | Human | Colorectum | FAP | 1.27e-07 | 7.70e-02 | -0.1294 |
80221 | ACSF2 | A001-C-108 | Human | Colorectum | FAP | 8.51e-04 | -1.98e-01 | -0.0272 |
80221 | ACSF2 | A002-C-205 | Human | Colorectum | FAP | 1.19e-07 | -2.94e-01 | -0.1236 |
80221 | ACSF2 | A015-C-006 | Human | Colorectum | FAP | 5.24e-04 | -2.66e-01 | -0.0994 |
80221 | ACSF2 | A002-C-114 | Human | Colorectum | FAP | 1.19e-04 | -1.76e-01 | -0.1561 |
80221 | ACSF2 | A015-C-104 | Human | Colorectum | FAP | 1.11e-07 | -8.63e-02 | -0.1899 |
80221 | ACSF2 | A001-C-014 | Human | Colorectum | FAP | 8.59e-04 | -2.11e-01 | 0.0135 |
80221 | ACSF2 | A002-C-016 | Human | Colorectum | FAP | 1.24e-06 | -2.37e-01 | 0.0521 |
80221 | ACSF2 | A015-C-002 | Human | Colorectum | FAP | 2.48e-02 | -2.41e-01 | -0.0763 |
80221 | ACSF2 | A001-C-203 | Human | Colorectum | FAP | 1.24e-02 | -7.30e-02 | -0.0481 |
80221 | ACSF2 | A002-C-116 | Human | Colorectum | FAP | 3.19e-10 | -2.31e-01 | -0.0452 |
80221 | ACSF2 | A014-C-008 | Human | Colorectum | FAP | 1.01e-02 | -1.96e-01 | -0.191 |
80221 | ACSF2 | A018-E-020 | Human | Colorectum | FAP | 3.11e-04 | -1.60e-01 | -0.2034 |
80221 | ACSF2 | F034 | Human | Colorectum | FAP | 2.08e-05 | -1.54e-01 | -0.0665 |
80221 | ACSF2 | F072B | Human | Colorectum | FAP | 1.78e-02 | -1.81e-01 | 0.257 |
80221 | ACSF2 | HCC1_Meng | Human | Liver | HCC | 3.28e-17 | 3.96e-03 | 0.0246 |
80221 | ACSF2 | HCC2_Meng | Human | Liver | HCC | 1.42e-04 | 1.38e-03 | 0.0107 |
80221 | ACSF2 | HCC1 | Human | Liver | HCC | 5.13e-03 | 2.21e+00 | 0.5336 |
80221 | ACSF2 | HCC2 | Human | Liver | HCC | 2.53e-03 | 1.33e+00 | 0.5341 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0033865 | Colorectum | AD | nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
GO:0033875 | Colorectum | AD | ribonucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
GO:0034032 | Colorectum | AD | purine nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
GO:00091504 | Colorectum | FAP | purine ribonucleotide metabolic process | 96/2622 | 368/18723 | 4.91e-10 | 1.20e-07 | 96 |
GO:00061634 | Colorectum | FAP | purine nucleotide metabolic process | 100/2622 | 396/18723 | 1.45e-09 | 2.77e-07 | 100 |
GO:00092593 | Colorectum | FAP | ribonucleotide metabolic process | 97/2622 | 385/18723 | 2.90e-09 | 5.07e-07 | 97 |
GO:00725214 | Colorectum | FAP | purine-containing compound metabolic process | 101/2622 | 416/18723 | 1.11e-08 | 1.33e-06 | 101 |
GO:00196933 | Colorectum | FAP | ribose phosphate metabolic process | 97/2622 | 396/18723 | 1.35e-08 | 1.51e-06 | 97 |
GO:00091174 | Colorectum | FAP | nucleotide metabolic process | 105/2622 | 489/18723 | 3.52e-06 | 1.25e-04 | 105 |
GO:00067534 | Colorectum | FAP | nucleoside phosphate metabolic process | 105/2622 | 497/18723 | 7.47e-06 | 2.25e-04 | 105 |
GO:00066313 | Colorectum | FAP | fatty acid metabolic process | 81/2622 | 390/18723 | 1.43e-04 | 2.24e-03 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACSF2 | SNV | Missense_Mutation | c.416N>T | p.Ser139Phe | p.S139F | Q96CM8 | protein_coding | deleterious(0) | possibly_damaging(0.482) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
ACSF2 | SNV | Missense_Mutation | rs758567058 | c.452G>A | p.Arg151Gln | p.R151Q | Q96CM8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACSF2 | SNV | Missense_Mutation | c.1498N>A | p.Glu500Lys | p.E500K | Q96CM8 | protein_coding | deleterious(0) | benign(0.3) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
ACSF2 | SNV | Missense_Mutation | rs767097885 | c.1642N>A | p.Ala548Thr | p.A548T | Q96CM8 | protein_coding | deleterious(0.05) | benign(0.061) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ACSF2 | SNV | Missense_Mutation | c.1174N>T | p.Pro392Ser | p.P392S | Q96CM8 | protein_coding | deleterious(0.01) | possibly_damaging(0.718) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACSF2 | SNV | Missense_Mutation | novel | c.89N>T | p.Ser30Ile | p.S30I | Q96CM8 | protein_coding | tolerated_low_confidence(0.08) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACSF2 | SNV | Missense_Mutation | rs556604565 | c.943N>T | p.Arg315Cys | p.R315C | Q96CM8 | protein_coding | tolerated(0.15) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ACSF2 | SNV | Missense_Mutation | novel | c.1400N>T | p.Ala467Val | p.A467V | Q96CM8 | protein_coding | tolerated(0.92) | benign(0.401) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ACSF2 | SNV | Missense_Mutation | rs747334624 | c.1597N>T | p.Arg533Cys | p.R533C | Q96CM8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ACSF2 | SNV | Missense_Mutation | novel | c.1823N>T | p.Pro608Leu | p.P608L | Q96CM8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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