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Gene: ABTB1 |
Gene summary for ABTB1 |
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Gene information | Species | Human | Gene symbol | ABTB1 | Gene ID | 80325 |
Gene name | ankyrin repeat and BTB domain containing 1 | |
Gene Alias | BPOZ | |
Cytomap | 3q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q969K4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80325 | ABTB1 | LZE4T | Human | Esophagus | ESCC | 1.06e-06 | 2.15e-01 | 0.0811 |
80325 | ABTB1 | LZE7T | Human | Esophagus | ESCC | 2.49e-11 | 4.51e-01 | 0.0667 |
80325 | ABTB1 | LZE8T | Human | Esophagus | ESCC | 6.49e-04 | 1.23e-01 | 0.067 |
80325 | ABTB1 | LZE22D1 | Human | Esophagus | HGIN | 3.40e-04 | 1.64e-01 | 0.0595 |
80325 | ABTB1 | LZE22T | Human | Esophagus | ESCC | 6.46e-06 | 3.07e-01 | 0.068 |
80325 | ABTB1 | LZE24T | Human | Esophagus | ESCC | 2.28e-23 | 4.95e-01 | 0.0596 |
80325 | ABTB1 | LZE6T | Human | Esophagus | ESCC | 2.43e-08 | 3.13e-01 | 0.0845 |
80325 | ABTB1 | P1T-E | Human | Esophagus | ESCC | 1.00e-06 | 3.92e-01 | 0.0875 |
80325 | ABTB1 | P2T-E | Human | Esophagus | ESCC | 1.74e-32 | 6.57e-01 | 0.1177 |
80325 | ABTB1 | P4T-E | Human | Esophagus | ESCC | 1.94e-07 | 1.60e-01 | 0.1323 |
80325 | ABTB1 | P5T-E | Human | Esophagus | ESCC | 4.63e-08 | 9.39e-02 | 0.1327 |
80325 | ABTB1 | P8T-E | Human | Esophagus | ESCC | 1.74e-13 | 3.75e-01 | 0.0889 |
80325 | ABTB1 | P9T-E | Human | Esophagus | ESCC | 1.04e-11 | 2.47e-01 | 0.1131 |
80325 | ABTB1 | P10T-E | Human | Esophagus | ESCC | 6.29e-18 | 3.60e-01 | 0.116 |
80325 | ABTB1 | P11T-E | Human | Esophagus | ESCC | 1.92e-10 | 3.85e-01 | 0.1426 |
80325 | ABTB1 | P12T-E | Human | Esophagus | ESCC | 1.77e-18 | 3.80e-01 | 0.1122 |
80325 | ABTB1 | P15T-E | Human | Esophagus | ESCC | 2.48e-20 | 4.16e-01 | 0.1149 |
80325 | ABTB1 | P16T-E | Human | Esophagus | ESCC | 6.79e-47 | 9.00e-01 | 0.1153 |
80325 | ABTB1 | P17T-E | Human | Esophagus | ESCC | 2.41e-05 | 1.51e-01 | 0.1278 |
80325 | ABTB1 | P19T-E | Human | Esophagus | ESCC | 9.93e-08 | 3.20e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641418 | Esophagus | HGIN | translational elongation | 22/2587 | 55/18723 | 1.46e-06 | 5.56e-05 | 22 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:000641416 | Oral cavity | OSCC | translational elongation | 37/7305 | 55/18723 | 2.03e-05 | 1.94e-04 | 37 |
GO:000641417 | Oral cavity | LP | translational elongation | 25/4623 | 55/18723 | 6.27e-04 | 5.71e-03 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABTB1 | SNV | Missense_Mutation | rs148820470 | c.1277N>T | p.Ala426Val | p.A426V | Q969K4 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ABTB1 | SNV | Missense_Mutation | c.584N>A | p.Cys195Tyr | p.C195Y | Q969K4 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ABTB1 | SNV | Missense_Mutation | novel | c.821T>C | p.Ile274Thr | p.I274T | Q969K4 | protein_coding | tolerated(0.08) | benign(0.023) | TCGA-AG-3878-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ABTB1 | deletion | Frame_Shift_Del | c.948delN | p.Pro318GlnfsTer36 | p.P318Qfs*36 | Q969K4 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ABTB1 | deletion | Frame_Shift_Del | c.748delN | p.Glu252SerfsTer102 | p.E252Sfs*102 | Q969K4 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
ABTB1 | deletion | Frame_Shift_Del | c.948delN | p.Pro318GlnfsTer36 | p.P318Qfs*36 | Q969K4 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
ABTB1 | SNV | Missense_Mutation | novel | c.1112N>T | p.Ser371Ile | p.S371I | Q969K4 | protein_coding | tolerated(0.4) | benign(0.014) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ABTB1 | SNV | Missense_Mutation | rs766497757 | c.1301C>T | p.Thr434Met | p.T434M | Q969K4 | protein_coding | tolerated(0.06) | possibly_damaging(0.496) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABTB1 | SNV | Missense_Mutation | novel | c.574N>A | p.Ala192Thr | p.A192T | Q969K4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABTB1 | SNV | Missense_Mutation | rs368990352 | c.958N>A | p.Val320Ile | p.V320I | Q969K4 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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