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Gene: ABHD15 |
Gene summary for ABHD15 |
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Gene information | Species | Human | Gene symbol | ABHD15 | Gene ID | 116236 |
Gene name | abhydrolase domain containing 15 | |
Gene Alias | ABHD15 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q6UXT9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116236 | ABHD15 | HCC1_Meng | Human | Liver | HCC | 6.99e-08 | -1.86e-02 | 0.0246 |
116236 | ABHD15 | HCC2_Meng | Human | Liver | HCC | 8.73e-04 | 1.89e-02 | 0.0107 |
116236 | ABHD15 | HCC2 | Human | Liver | HCC | 7.20e-32 | 3.15e+00 | 0.5341 |
116236 | ABHD15 | HCC5 | Human | Liver | HCC | 1.95e-11 | 1.45e+00 | 0.4932 |
116236 | ABHD15 | S014 | Human | Liver | HCC | 7.72e-08 | 3.60e-01 | 0.2254 |
116236 | ABHD15 | S015 | Human | Liver | HCC | 4.89e-07 | 3.84e-01 | 0.2375 |
116236 | ABHD15 | S016 | Human | Liver | HCC | 1.05e-10 | 3.89e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABHD15 | SNV | Missense_Mutation | c.1082N>T | p.Pro361Leu | p.P361L | Q6UXT9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2H2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABHD15 | SNV | Missense_Mutation | rs752129442 | c.944N>A | p.Arg315Gln | p.R315Q | Q6UXT9 | protein_coding | deleterious(0.05) | possibly_damaging(0.692) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ABHD15 | SNV | Missense_Mutation | rs201924599 | c.1315C>T | p.Arg439Cys | p.R439C | Q6UXT9 | protein_coding | deleterious(0.01) | benign(0) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABHD15 | SNV | Missense_Mutation | novel | c.1195N>T | p.Pro399Ser | p.P399S | Q6UXT9 | protein_coding | tolerated(0.64) | benign(0.014) | TCGA-77-8144-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ABHD15 | SNV | Missense_Mutation | novel | c.899A>T | p.Glu300Val | p.E300V | Q6UXT9 | protein_coding | tolerated(0.15) | benign(0.085) | TCGA-85-A4QR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ABHD15 | SNV | Missense_Mutation | novel | c.804C>G | p.Cys268Trp | p.C268W | Q6UXT9 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-98-A538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ABHD15 | SNV | Missense_Mutation | novel | c.424G>C | p.Gly142Arg | p.G142R | Q6UXT9 | protein_coding | tolerated(0.11) | benign(0.073) | TCGA-BA-5556-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABHD15 | SNV | Missense_Mutation | rs374284598 | c.1048N>T | p.Val350Leu | p.V350L | Q6UXT9 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-CQ-6218-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ABHD15 | SNV | Missense_Mutation | novel | c.1088N>C | p.Cys363Ser | p.C363S | Q6UXT9 | protein_coding | tolerated(0.34) | benign(0.065) | TCGA-D6-A4ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ABHD15 | SNV | Missense_Mutation | c.817N>A | p.Glu273Lys | p.E273K | Q6UXT9 | protein_coding | deleterious(0) | benign(0.336) | TCGA-BR-7703-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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