![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AACS |
Gene summary for AACS |
![]() |
Gene information | Species | Human | Gene symbol | AACS | Gene ID | 65985 |
Gene name | acetoacetyl-CoA synthetase | |
Gene Alias | ACSF1 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | Q86V21 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65985 | AACS | LZE24T | Human | Esophagus | ESCC | 1.53e-08 | 3.01e-01 | 0.0596 |
65985 | AACS | P1T-E | Human | Esophagus | ESCC | 7.87e-05 | 1.69e-01 | 0.0875 |
65985 | AACS | P2T-E | Human | Esophagus | ESCC | 1.13e-21 | 3.35e-01 | 0.1177 |
65985 | AACS | P4T-E | Human | Esophagus | ESCC | 8.55e-13 | 3.91e-01 | 0.1323 |
65985 | AACS | P5T-E | Human | Esophagus | ESCC | 8.85e-15 | 2.44e-01 | 0.1327 |
65985 | AACS | P8T-E | Human | Esophagus | ESCC | 9.81e-13 | 2.38e-01 | 0.0889 |
65985 | AACS | P9T-E | Human | Esophagus | ESCC | 3.45e-07 | 5.87e-02 | 0.1131 |
65985 | AACS | P10T-E | Human | Esophagus | ESCC | 3.16e-15 | 2.11e-01 | 0.116 |
65985 | AACS | P11T-E | Human | Esophagus | ESCC | 6.14e-06 | 2.59e-01 | 0.1426 |
65985 | AACS | P12T-E | Human | Esophagus | ESCC | 1.75e-15 | 2.45e-01 | 0.1122 |
65985 | AACS | P15T-E | Human | Esophagus | ESCC | 1.70e-16 | 2.15e-01 | 0.1149 |
65985 | AACS | P16T-E | Human | Esophagus | ESCC | 4.77e-07 | 2.02e-01 | 0.1153 |
65985 | AACS | P17T-E | Human | Esophagus | ESCC | 3.30e-04 | 1.94e-01 | 0.1278 |
65985 | AACS | P19T-E | Human | Esophagus | ESCC | 2.44e-02 | 6.31e-01 | 0.1662 |
65985 | AACS | P20T-E | Human | Esophagus | ESCC | 5.69e-21 | 4.03e-01 | 0.1124 |
65985 | AACS | P21T-E | Human | Esophagus | ESCC | 6.04e-14 | 2.79e-01 | 0.1617 |
65985 | AACS | P22T-E | Human | Esophagus | ESCC | 3.13e-06 | 1.20e-01 | 0.1236 |
65985 | AACS | P23T-E | Human | Esophagus | ESCC | 9.20e-12 | 3.89e-01 | 0.108 |
65985 | AACS | P24T-E | Human | Esophagus | ESCC | 4.05e-09 | 1.58e-01 | 0.1287 |
65985 | AACS | P26T-E | Human | Esophagus | ESCC | 2.02e-09 | 1.13e-01 | 0.1276 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:000758410 | Esophagus | ESCC | response to nutrient | 114/8552 | 174/18723 | 9.43e-08 | 1.56e-06 | 114 |
GO:0061008110 | Esophagus | ESCC | hepaticobiliary system development | 98/8552 | 150/18723 | 8.91e-07 | 1.15e-05 | 98 |
GO:0001889110 | Esophagus | ESCC | liver development | 96/8552 | 147/18723 | 1.18e-06 | 1.47e-05 | 96 |
GO:1901654111 | Esophagus | ESCC | response to ketone | 118/8552 | 194/18723 | 1.45e-05 | 1.31e-04 | 118 |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:19016556 | Esophagus | ESCC | cellular response to ketone | 59/8552 | 96/18723 | 1.32e-03 | 6.30e-03 | 59 |
GO:003357415 | Esophagus | ESCC | response to testosterone | 29/8552 | 42/18723 | 1.87e-03 | 8.46e-03 | 29 |
GO:0097305111 | Esophagus | ESCC | response to alcohol | 138/8552 | 253/18723 | 2.70e-03 | 1.14e-02 | 138 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:007169210 | Esophagus | ESCC | protein localization to extracellular region | 193/8552 | 368/18723 | 5.01e-03 | 1.92e-02 | 193 |
GO:0009743111 | Esophagus | ESCC | response to carbohydrate | 135/8552 | 253/18723 | 8.16e-03 | 2.89e-02 | 135 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002809 | Esophagus | ESCC | Valine, leucine and isoleucine degradation | 34/4205 | 48/8465 | 2.34e-03 | 6.54e-03 | 3.35e-03 | 34 |
hsa0028014 | Esophagus | ESCC | Valine, leucine and isoleucine degradation | 34/4205 | 48/8465 | 2.34e-03 | 6.54e-03 | 3.35e-03 | 34 |
hsa0028021 | Liver | Cirrhotic | Valine, leucine and isoleucine degradation | 32/2530 | 48/8465 | 1.45e-07 | 2.02e-06 | 1.24e-06 | 32 |
hsa006502 | Liver | Cirrhotic | Butanoate metabolism | 15/2530 | 27/8465 | 4.71e-03 | 1.74e-02 | 1.07e-02 | 15 |
hsa0028031 | Liver | Cirrhotic | Valine, leucine and isoleucine degradation | 32/2530 | 48/8465 | 1.45e-07 | 2.02e-06 | 1.24e-06 | 32 |
hsa006503 | Liver | Cirrhotic | Butanoate metabolism | 15/2530 | 27/8465 | 4.71e-03 | 1.74e-02 | 1.07e-02 | 15 |
hsa0028041 | Liver | HCC | Valine, leucine and isoleucine degradation | 41/4020 | 48/8465 | 4.84e-08 | 7.05e-07 | 3.92e-07 | 41 |
hsa0028051 | Liver | HCC | Valine, leucine and isoleucine degradation | 41/4020 | 48/8465 | 4.84e-08 | 7.05e-07 | 3.92e-07 | 41 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AACS | SNV | Missense_Mutation | rs552840406 | c.701N>C | p.Lys234Thr | p.K234T | Q86V21 | protein_coding | deleterious(0.03) | benign(0.165) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
AACS | SNV | Missense_Mutation | c.973N>T | p.Asp325Tyr | p.D325Y | Q86V21 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
AACS | SNV | Missense_Mutation | c.754A>G | p.Lys252Glu | p.K252E | Q86V21 | protein_coding | tolerated(0.43) | benign(0.253) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
AACS | SNV | Missense_Mutation | rs765733198 | c.1942N>A | p.Val648Met | p.V648M | Q86V21 | protein_coding | deleterious(0) | possibly_damaging(0.572) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AACS | SNV | Missense_Mutation | novel | c.580N>A | p.Asp194Asn | p.D194N | Q86V21 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
AACS | SNV | Missense_Mutation | novel | c.1624G>A | p.Gly542Ser | p.G542S | Q86V21 | protein_coding | deleterious(0.03) | benign(0.319) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AACS | SNV | Missense_Mutation | rs752378439 | c.1246N>T | p.Ala416Ser | p.A416S | Q86V21 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AACS | SNV | Missense_Mutation | c.562N>A | p.Gly188Ser | p.G188S | Q86V21 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR | |
AACS | SNV | Missense_Mutation | rs200966429 | c.1780G>A | p.Ala594Thr | p.A594T | Q86V21 | protein_coding | tolerated(0.87) | benign(0) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
AACS | SNV | Missense_Mutation | c.886G>A | p.Ala296Thr | p.A296T | Q86V21 | protein_coding | tolerated(0.09) | benign(0.084) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |