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Gene: PTPRM |
Gene summary for PTPRM |
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Gene information | Species | Human | Gene symbol | PTPRM | Gene ID | 5797 |
Gene name | protein tyrosine phosphatase receptor type M | |
Gene Alias | PTPRL1 | |
Cytomap | 18p11.23 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P28827 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5797 | PTPRM | AEH-subject1 | Human | Endometrium | AEH | 1.75e-60 | 1.11e+00 | -0.3059 |
5797 | PTPRM | AEH-subject2 | Human | Endometrium | AEH | 8.56e-44 | 1.01e+00 | -0.2525 |
5797 | PTPRM | AEH-subject3 | Human | Endometrium | AEH | 3.71e-40 | 9.59e-01 | -0.2576 |
5797 | PTPRM | AEH-subject4 | Human | Endometrium | AEH | 1.13e-45 | 1.14e+00 | -0.2657 |
5797 | PTPRM | AEH-subject5 | Human | Endometrium | AEH | 1.36e-52 | 1.12e+00 | -0.2953 |
5797 | PTPRM | EEC-subject1 | Human | Endometrium | EEC | 4.75e-66 | 1.26e+00 | -0.2682 |
5797 | PTPRM | EEC-subject2 | Human | Endometrium | EEC | 3.40e-80 | 1.32e+00 | -0.2607 |
5797 | PTPRM | EEC-subject3 | Human | Endometrium | EEC | 1.25e-08 | 4.17e-01 | -0.2525 |
5797 | PTPRM | EEC-subject4 | Human | Endometrium | EEC | 1.57e-21 | 7.71e-01 | -0.2571 |
5797 | PTPRM | EEC-subject5 | Human | Endometrium | EEC | 2.08e-31 | 9.15e-01 | -0.249 |
5797 | PTPRM | GSM5276935 | Human | Endometrium | EEC | 1.56e-02 | -1.16e-01 | -0.123 |
5797 | PTPRM | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.64e-03 | -1.35e-02 | -0.1883 |
5797 | PTPRM | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.10e-04 | -1.12e-01 | -0.1934 |
5797 | PTPRM | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.35e-04 | -8.05e-03 | -0.1917 |
5797 | PTPRM | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.44e-02 | 2.48e-02 | -0.1916 |
5797 | PTPRM | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.19e-13 | 5.29e-01 | -0.1269 |
5797 | PTPRM | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 4.42e-02 | 7.73e-01 | -0.1271 |
5797 | PTPRM | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 5.82e-05 | 9.09e-01 | -0.1406 |
5797 | PTPRM | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.29e-05 | 1.01e+00 | -0.1408 |
5797 | PTPRM | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 8.57e-09 | 1.17e+00 | -0.138 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000166710 | Endometrium | AEH | ameboidal-type cell migration | 90/2100 | 475/18723 | 3.73e-07 | 1.57e-05 | 90 |
GO:00506738 | Endometrium | AEH | epithelial cell proliferation | 84/2100 | 437/18723 | 4.88e-07 | 1.94e-05 | 84 |
GO:00074098 | Endometrium | AEH | axonogenesis | 81/2100 | 418/18723 | 5.54e-07 | 2.12e-05 | 81 |
GO:009013014 | Endometrium | AEH | tissue migration | 73/2100 | 365/18723 | 5.79e-07 | 2.20e-05 | 73 |
GO:00615648 | Endometrium | AEH | axon development | 88/2100 | 467/18723 | 6.39e-07 | 2.38e-05 | 88 |
GO:009013214 | Endometrium | AEH | epithelium migration | 72/2100 | 360/18723 | 6.90e-07 | 2.55e-05 | 72 |
GO:001063114 | Endometrium | AEH | epithelial cell migration | 71/2100 | 357/18723 | 1.02e-06 | 3.52e-05 | 71 |
GO:001063214 | Endometrium | AEH | regulation of epithelial cell migration | 60/2100 | 292/18723 | 2.31e-06 | 6.77e-05 | 60 |
GO:00506788 | Endometrium | AEH | regulation of epithelial cell proliferation | 73/2100 | 381/18723 | 3.04e-06 | 8.44e-05 | 73 |
GO:00303364 | Endometrium | AEH | negative regulation of cell migration | 65/2100 | 344/18723 | 1.65e-05 | 3.42e-04 | 65 |
GO:20001464 | Endometrium | AEH | negative regulation of cell motility | 67/2100 | 359/18723 | 1.86e-05 | 3.77e-04 | 67 |
GO:00512714 | Endometrium | AEH | negative regulation of cellular component movement | 68/2100 | 367/18723 | 2.06e-05 | 4.11e-04 | 68 |
GO:00435428 | Endometrium | AEH | endothelial cell migration | 55/2100 | 279/18723 | 2.11e-05 | 4.15e-04 | 55 |
GO:00105945 | Endometrium | AEH | regulation of endothelial cell migration | 47/2100 | 232/18723 | 4.02e-05 | 6.91e-04 | 47 |
GO:00400134 | Endometrium | AEH | negative regulation of locomotion | 70/2100 | 391/18723 | 4.95e-05 | 8.05e-04 | 70 |
GO:00064709 | Endometrium | AEH | protein dephosphorylation | 50/2100 | 281/18723 | 6.41e-04 | 6.23e-03 | 50 |
GO:00312902 | Endometrium | AEH | retinal ganglion cell axon guidance | 7/2100 | 19/18723 | 3.28e-03 | 2.30e-02 | 7 |
GO:000941010 | Endometrium | AEH | response to xenobiotic stimulus | 71/2100 | 462/18723 | 3.66e-03 | 2.50e-02 | 71 |
GO:0001935 | Endometrium | AEH | endothelial cell proliferation | 33/2100 | 193/18723 | 8.99e-03 | 4.87e-02 | 33 |
GO:006156412 | Endometrium | EEC | axon development | 93/2168 | 467/18723 | 9.60e-08 | 4.69e-06 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452025 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa04520111 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa0452026 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
hsa0452035 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
hsa0452016 | Lung | IAC | Adherens junction | 37/1053 | 93/8465 | 1.99e-11 | 2.16e-09 | 1.43e-09 | 37 |
hsa045146 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa0452017 | Lung | IAC | Adherens junction | 37/1053 | 93/8465 | 1.99e-11 | 2.16e-09 | 1.43e-09 | 37 |
hsa0451411 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa0452023 | Lung | AIS | Adherens junction | 34/961 | 93/8465 | 1.59e-10 | 1.29e-08 | 8.26e-09 | 34 |
hsa0452033 | Lung | AIS | Adherens junction | 34/961 | 93/8465 | 1.59e-10 | 1.29e-08 | 8.26e-09 | 34 |
hsa0452043 | Lung | AAH | Adherens junction | 16/348 | 93/8465 | 9.99e-07 | 9.29e-05 | 7.47e-05 | 16 |
hsa0452053 | Lung | AAH | Adherens junction | 16/348 | 93/8465 | 9.99e-07 | 9.29e-05 | 7.47e-05 | 16 |
hsa0452062 | Lung | MIAC | Adherens junction | 27/507 | 93/8465 | 2.36e-12 | 2.29e-10 | 1.66e-10 | 27 |
hsa0452072 | Lung | MIAC | Adherens junction | 27/507 | 93/8465 | 2.36e-12 | 2.29e-10 | 1.66e-10 | 27 |
hsa0452027 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa04520112 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Breast | Healthy |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Cervix | ADJ |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Cervix | CC |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | CRC | AD |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | CRC | ADJ |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | CRC | CRC |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | CRC | FAP |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | CRC | MSI-H |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | CRC | MSS |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | CRC | SER |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Endometrium | ADJ |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Endometrium | AEH |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Endometrium | EEC |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Endometrium | Healthy |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Esophagus | ESCC |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | Esophagus | Healthy |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | GC | ADJ |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | GC | GC |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | GC | Precancer |
PTPRM | PTPRM | PTPRM_PTPRM | PTPRM | HNSCC | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTPRM | SNV | Missense_Mutation | rs150274533 | c.1007N>T | p.Thr336Met | p.T336M | P28827 | protein_coding | tolerated(0.07) | possibly_damaging(0.67) | TCGA-CQ-5327-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
PTPRM | SNV | Missense_Mutation | novel | c.3753G>C | p.Glu1251Asp | p.E1251D | P28827 | protein_coding | tolerated(0.37) | probably_damaging(0.992) | TCGA-CQ-7063-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PTPRM | SNV | Missense_Mutation | novel | c.428N>A | p.Ala143Glu | p.A143E | P28827 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTPRM | SNV | Missense_Mutation | novel | c.842N>A | p.Pro281Gln | p.P281Q | P28827 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
PTPRM | SNV | Missense_Mutation | novel | c.3695N>T | p.Cys1232Phe | p.C1232F | P28827 | protein_coding | tolerated(0.74) | probably_damaging(0.997) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
PTPRM | SNV | Missense_Mutation | novel | c.2786N>C | p.Asp929Ala | p.D929A | P28827 | protein_coding | deleterious(0.01) | benign(0.173) | TCGA-CV-6948-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTPRM | SNV | Missense_Mutation | novel | c.3674G>A | p.Arg1225Gln | p.R1225Q | P28827 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CV-7243-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
PTPRM | SNV | Missense_Mutation | c.3088G>C | p.Glu1030Gln | p.E1030Q | P28827 | protein_coding | tolerated(0.05) | probably_damaging(0.988) | TCGA-CV-7427-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PTPRM | SNV | Missense_Mutation | novel | c.1142N>A | p.Arg381Gln | p.R381Q | P28827 | protein_coding | tolerated(0.21) | benign(0.259) | TCGA-CV-A45O-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PTPRM | SNV | Missense_Mutation | rs569455729 | c.2410N>A | p.Glu804Lys | p.E804K | P28827 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-CV-A45W-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5797 | PTPRM | DRUGGABLE GENOME, PROTEIN PHOSPHATASE | methotrexate | METHOTREXATE | 24583629 | |
5797 | PTPRM | DRUGGABLE GENOME, PROTEIN PHOSPHATASE | inhibitor | 252827513 |
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