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Gene: PLCB4 |
Gene summary for PLCB4 |
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Gene information | Species | Human | Gene symbol | PLCB4 | Gene ID | 5332 |
Gene name | phospholipase C beta 4 | |
Gene Alias | ARCND2 | |
Cytomap | 20p12.3-p12.2 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q15147 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5332 | PLCB4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.84e-10 | 8.63e-01 | -0.0811 |
5332 | PLCB4 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.21e-03 | 8.74e-01 | -0.1088 |
5332 | PLCB4 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.46e-16 | 9.22e-01 | -0.1954 |
5332 | PLCB4 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.51e-04 | 4.29e-01 | -0.1001 |
5332 | PLCB4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.01e-06 | 7.33e-01 | -0.059 |
5332 | PLCB4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.17e-04 | -7.52e-01 | -0.2061 |
5332 | PLCB4 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.71e-06 | 6.28e-01 | -0.0842 |
5332 | PLCB4 | HTA11_6801_2000001011 | Human | Colorectum | SER | 6.49e-07 | -9.55e-01 | 0.0171 |
5332 | PLCB4 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.28e-07 | 7.58e-01 | 0.0112 |
5332 | PLCB4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.01e-17 | 1.22e+00 | 0.0588 |
5332 | PLCB4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.31e-03 | 5.03e-01 | 0.294 |
5332 | PLCB4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.91e-17 | 1.18e+00 | 0.281 |
5332 | PLCB4 | F007 | Human | Colorectum | FAP | 4.32e-18 | 4.95e-01 | 0.1176 |
5332 | PLCB4 | A002-C-010 | Human | Colorectum | FAP | 1.07e-27 | 4.49e-01 | 0.242 |
5332 | PLCB4 | A001-C-207 | Human | Colorectum | FAP | 2.20e-11 | 3.12e-01 | 0.1278 |
5332 | PLCB4 | A015-C-203 | Human | Colorectum | FAP | 4.20e-30 | -1.51e-01 | -0.1294 |
5332 | PLCB4 | A015-C-204 | Human | Colorectum | FAP | 5.55e-06 | 1.09e-01 | -0.0228 |
5332 | PLCB4 | A014-C-040 | Human | Colorectum | FAP | 1.20e-05 | 2.33e-01 | -0.1184 |
5332 | PLCB4 | A002-C-201 | Human | Colorectum | FAP | 2.87e-15 | 3.12e-02 | 0.0324 |
5332 | PLCB4 | A002-C-203 | Human | Colorectum | FAP | 1.93e-12 | 3.01e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0048017 | Colorectum | AD | inositol lipid-mediated signaling | 53/3918 | 182/18723 | 5.35e-03 | 3.52e-02 | 53 |
GO:0048015 | Colorectum | AD | phosphatidylinositol-mediated signaling | 52/3918 | 178/18723 | 5.37e-03 | 3.54e-02 | 52 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:00480171 | Colorectum | SER | inositol lipid-mediated signaling | 42/2897 | 182/18723 | 4.36e-03 | 3.49e-02 | 42 |
GO:00480151 | Colorectum | SER | phosphatidylinositol-mediated signaling | 41/2897 | 178/18723 | 4.97e-03 | 3.86e-02 | 41 |
GO:00160422 | Colorectum | MSS | lipid catabolic process | 77/3467 | 320/18723 | 7.43e-03 | 4.71e-02 | 77 |
GO:00160423 | Colorectum | FAP | lipid catabolic process | 65/2622 | 320/18723 | 1.13e-03 | 1.08e-02 | 65 |
GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
GO:00160424 | Colorectum | CRC | lipid catabolic process | 53/2078 | 320/18723 | 1.89e-03 | 1.93e-02 | 53 |
GO:00160427 | Esophagus | ESCC | lipid catabolic process | 168/8552 | 320/18723 | 7.97e-03 | 2.84e-02 | 168 |
GO:001604221 | Liver | HCC | lipid catabolic process | 175/7958 | 320/18723 | 6.50e-06 | 7.88e-05 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05017 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa04723 | Colorectum | AD | Retrograde endocannabinoid signaling | 59/2092 | 148/8465 | 2.94e-05 | 2.73e-04 | 1.74e-04 | 59 |
hsa04961 | Colorectum | AD | Endocrine and other factor-regulated calcium reabsorption | 24/2092 | 53/8465 | 8.49e-04 | 5.93e-03 | 3.78e-03 | 24 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa05417 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa04912 | Colorectum | AD | GnRH signaling pathway | 35/2092 | 93/8465 | 3.69e-03 | 1.90e-02 | 1.21e-02 | 35 |
hsa04071 | Colorectum | AD | Sphingolipid signaling pathway | 43/2092 | 121/8465 | 4.83e-03 | 2.28e-02 | 1.45e-02 | 43 |
hsa04728 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa04971 | Colorectum | AD | Gastric acid secretion | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
hsa04928 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa04720 | Colorectum | AD | Long-term potentiation | 26/2092 | 67/8465 | 7.26e-03 | 2.97e-02 | 1.89e-02 | 26 |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLCB4 | SNV | Missense_Mutation | c.1180G>A | p.Glu394Lys | p.E394K | Q15147 | protein_coding | deleterious(0) | benign(0.392) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
PLCB4 | SNV | Missense_Mutation | rs148851937 | c.2278C>T | p.Arg760Trp | p.R760W | Q15147 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
PLCB4 | SNV | Missense_Mutation | rs771325329 | c.3307N>T | p.Arg1103Trp | p.R1103W | Q15147 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PLCB4 | SNV | Missense_Mutation | c.2161N>C | p.Tyr721His | p.Y721H | Q15147 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
PLCB4 | SNV | Missense_Mutation | c.1144N>T | p.Asp382Tyr | p.D382Y | Q15147 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLCB4 | SNV | Missense_Mutation | c.2242N>G | p.Leu748Val | p.L748V | Q15147 | protein_coding | tolerated(0.09) | probably_damaging(0.925) | TCGA-HU-A4H0-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PLCB4 | SNV | Missense_Mutation | rs759180836 | c.3230G>A | p.Arg1077Gln | p.R1077Q | Q15147 | protein_coding | deleterious(0.02) | benign(0.149) | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PLCB4 | SNV | Missense_Mutation | novel | c.2420A>G | p.Lys807Arg | p.K807R | Q15147 | protein_coding | tolerated(0.83) | benign(0.063) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
PLCB4 | SNV | Missense_Mutation | novel | c.426N>G | p.Ser142Arg | p.S142R | Q15147 | protein_coding | deleterious(0.01) | possibly_damaging(0.718) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
PLCB4 | deletion | Frame_Shift_Del | rs758685931 | c.2994_2995delNN | p.Glu999AsnfsTer13 | p.E999Nfs*13 | Q15147 | protein_coding | TCGA-BR-A4IU-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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