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Gene: PARP14 |
Gene summary for PARP14 |
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Gene information | Species | Human | Gene symbol | PARP14 | Gene ID | 54625 |
Gene name | poly(ADP-ribose) polymerase family member 14 | |
Gene Alias | ARTD8 | |
Cytomap | 3q21.1 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q460N5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54625 | PARP14 | CA_HPV_1 | Human | Cervix | CC | 5.08e-14 | 5.03e-01 | 0.0264 |
54625 | PARP14 | CA_HPV_2 | Human | Cervix | CC | 1.09e-12 | 5.47e-01 | 0.0391 |
54625 | PARP14 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 3.96e-06 | 3.16e-01 | 0.0208 |
54625 | PARP14 | CCI_2 | Human | Cervix | CC | 2.36e-16 | 2.01e+00 | 0.5249 |
54625 | PARP14 | CCI_3 | Human | Cervix | CC | 3.29e-17 | 1.48e+00 | 0.516 |
54625 | PARP14 | Tumor | Human | Cervix | CC | 1.87e-06 | 3.53e-01 | 0.1241 |
54625 | PARP14 | sample1 | Human | Cervix | CC | 8.03e-17 | 8.78e-01 | 0.0959 |
54625 | PARP14 | sample3 | Human | Cervix | CC | 3.01e-24 | 5.44e-01 | 0.1387 |
54625 | PARP14 | T1 | Human | Cervix | CC | 9.14e-47 | 1.04e+00 | 0.0918 |
54625 | PARP14 | T3 | Human | Cervix | CC | 1.54e-19 | 4.69e-01 | 0.1389 |
54625 | PARP14 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.52e-12 | 8.34e-01 | 0.294 |
54625 | PARP14 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 9.93e-03 | 1.10e+00 | 0.3487 |
54625 | PARP14 | A015-C-203 | Human | Colorectum | FAP | 1.61e-06 | 2.84e-01 | -0.1294 |
54625 | PARP14 | A001-C-108 | Human | Colorectum | FAP | 1.49e-03 | 4.31e-01 | -0.0272 |
54625 | PARP14 | A002-C-205 | Human | Colorectum | FAP | 4.69e-06 | 3.10e-01 | -0.1236 |
54625 | PARP14 | A015-C-006 | Human | Colorectum | FAP | 3.90e-05 | 3.69e-01 | -0.0994 |
54625 | PARP14 | A015-C-104 | Human | Colorectum | FAP | 3.81e-06 | 2.72e-01 | -0.1899 |
54625 | PARP14 | A002-C-116 | Human | Colorectum | FAP | 1.26e-04 | 1.77e-01 | -0.0452 |
54625 | PARP14 | A018-E-020 | Human | Colorectum | FAP | 1.26e-02 | 1.95e-01 | -0.2034 |
54625 | PARP14 | LZE4T | Human | Esophagus | ESCC | 2.39e-11 | 3.35e-01 | 0.0811 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:00028315 | Cervix | CC | regulation of response to biotic stimulus | 67/2311 | 327/18723 | 1.79e-05 | 3.36e-04 | 67 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
GO:00028322 | Cervix | CC | negative regulation of response to biotic stimulus | 27/2311 | 108/18723 | 2.27e-04 | 2.55e-03 | 27 |
GO:00192213 | Cervix | CC | cytokine-mediated signaling pathway | 84/2311 | 472/18723 | 3.25e-04 | 3.44e-03 | 84 |
GO:00507773 | Cervix | CC | negative regulation of immune response | 41/2311 | 194/18723 | 3.63e-04 | 3.76e-03 | 41 |
GO:00321022 | Cervix | CC | negative regulation of response to external stimulus | 75/2311 | 420/18723 | 5.96e-04 | 5.61e-03 | 75 |
GO:00450882 | Cervix | CC | regulation of innate immune response | 44/2311 | 218/18723 | 6.40e-04 | 5.97e-03 | 44 |
GO:00343415 | Cervix | CC | response to interferon-gamma | 30/2311 | 141/18723 | 1.88e-03 | 1.39e-02 | 30 |
GO:00458243 | Cervix | CC | negative regulation of innate immune response | 18/2311 | 71/18723 | 2.01e-03 | 1.47e-02 | 18 |
GO:0031348 | Cervix | CC | negative regulation of defense response | 48/2311 | 258/18723 | 2.30e-03 | 1.65e-02 | 48 |
GO:00603333 | Cervix | CC | interferon-gamma-mediated signaling pathway | 9/2311 | 27/18723 | 3.82e-03 | 2.41e-02 | 9 |
GO:00713463 | Cervix | CC | cellular response to interferon-gamma | 25/2311 | 118/18723 | 4.54e-03 | 2.75e-02 | 25 |
GO:00019612 | Cervix | CC | positive regulation of cytokine-mediated signaling pathway | 13/2311 | 50/18723 | 6.42e-03 | 3.58e-02 | 13 |
GO:00607602 | Cervix | CC | positive regulation of response to cytokine stimulus | 14/2311 | 57/18723 | 8.17e-03 | 4.25e-02 | 14 |
GO:00603303 | Cervix | CC | regulation of response to interferon-gamma | 6/2311 | 16/18723 | 9.35e-03 | 4.66e-02 | 6 |
GO:00603343 | Cervix | CC | regulation of interferon-gamma-mediated signaling pathway | 6/2311 | 16/18723 | 9.35e-03 | 4.66e-02 | 6 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PARP14 | SNV | Missense_Mutation | c.5359T>G | p.Tyr1787Asp | p.Y1787D | Q460N5 | protein_coding | tolerated(0.73) | possibly_damaging(0.907) | TCGA-HC-8262-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD | |
PARP14 | SNV | Missense_Mutation | c.4469A>G | p.His1490Arg | p.H1490R | Q460N5 | protein_coding | tolerated(0.46) | benign(0) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PARP14 | SNV | Missense_Mutation | c.4726T>C | p.Tyr1576His | p.Y1576H | Q460N5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PARP14 | SNV | Missense_Mutation | c.3169N>C | p.Glu1057Gln | p.E1057Q | Q460N5 | protein_coding | tolerated(0.34) | benign(0.022) | TCGA-BR-4357-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PARP14 | SNV | Missense_Mutation | c.4466N>G | p.Asp1489Gly | p.D1489G | Q460N5 | protein_coding | deleterious(0.01) | benign(0.01) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PARP14 | SNV | Missense_Mutation | c.824T>C | p.Phe275Ser | p.F275S | Q460N5 | protein_coding | tolerated(0.52) | benign(0.072) | TCGA-BR-6454-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PARP14 | SNV | Missense_Mutation | novel | c.2694N>C | p.Arg898Ser | p.R898S | Q460N5 | protein_coding | deleterious(0) | benign(0.02) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PARP14 | SNV | Missense_Mutation | c.134N>A | p.Arg45His | p.R45H | Q460N5 | protein_coding | tolerated(0.66) | benign(0.24) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PARP14 | SNV | Missense_Mutation | c.863T>C | p.Leu288Pro | p.L288P | Q460N5 | protein_coding | deleterious(0.03) | possibly_damaging(0.726) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PARP14 | SNV | Missense_Mutation | c.1376A>C | p.Lys459Thr | p.K459T | Q460N5 | protein_coding | deleterious(0.01) | possibly_damaging(0.541) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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