![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MYOF |
Gene summary for MYOF |
![]() |
Gene information | Species | Human | Gene symbol | MYOF | Gene ID | 26509 |
Gene name | myoferlin | |
Gene Alias | FER1L3 | |
Cytomap | 10q23.33 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | Q9NZM1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26509 | MYOF | CA_HPV_3 | Human | Cervix | CC | 1.81e-05 | 7.25e-02 | 0.0414 |
26509 | MYOF | N_HPV_1 | Human | Cervix | N_HPV | 1.32e-02 | -2.71e-01 | 0.0079 |
26509 | MYOF | CCI_1 | Human | Cervix | CC | 7.68e-12 | 1.31e+00 | 0.528 |
26509 | MYOF | CCI_2 | Human | Cervix | CC | 4.01e-04 | 7.37e-01 | 0.5249 |
26509 | MYOF | Tumor | Human | Cervix | CC | 1.79e-04 | 2.37e-01 | 0.1241 |
26509 | MYOF | sample3 | Human | Cervix | CC | 4.07e-14 | 3.36e-01 | 0.1387 |
26509 | MYOF | T3 | Human | Cervix | CC | 3.28e-11 | 3.21e-01 | 0.1389 |
26509 | MYOF | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.61e-08 | 3.23e-01 | 0.0155 |
26509 | MYOF | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.71e-05 | 5.28e-01 | -0.1808 |
26509 | MYOF | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.29e-24 | 1.06e+00 | -0.0811 |
26509 | MYOF | HTA11_78_2000001011 | Human | Colorectum | AD | 2.63e-15 | 8.48e-01 | -0.1088 |
26509 | MYOF | HTA11_347_2000001011 | Human | Colorectum | AD | 7.63e-23 | 7.81e-01 | -0.1954 |
26509 | MYOF | HTA11_411_2000001011 | Human | Colorectum | SER | 1.51e-07 | 1.22e+00 | -0.2602 |
26509 | MYOF | HTA11_696_2000001011 | Human | Colorectum | AD | 4.28e-25 | 9.22e-01 | -0.1464 |
26509 | MYOF | HTA11_866_2000001011 | Human | Colorectum | AD | 1.42e-10 | 5.01e-01 | -0.1001 |
26509 | MYOF | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.35e-21 | 9.92e-01 | -0.059 |
26509 | MYOF | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.11e-05 | 6.93e-01 | -0.2061 |
26509 | MYOF | HTA11_546_2000001011 | Human | Colorectum | AD | 5.20e-03 | 3.71e-01 | -0.0842 |
26509 | MYOF | HTA11_866_3004761011 | Human | Colorectum | AD | 1.24e-02 | 3.30e-01 | 0.096 |
26509 | MYOF | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.38e-06 | 4.05e-01 | 0.0674 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:0000768 | Cervix | CC | syncytium formation by plasma membrane fusion | 15/2311 | 55/18723 | 2.14e-03 | 1.54e-02 | 15 |
GO:0140253 | Cervix | CC | cell-cell fusion | 15/2311 | 55/18723 | 2.14e-03 | 1.54e-02 | 15 |
GO:00069491 | Cervix | CC | syncytium formation | 15/2311 | 57/18723 | 3.13e-03 | 2.05e-02 | 15 |
GO:00511464 | Cervix | CC | striated muscle cell differentiation | 50/2311 | 283/18723 | 5.53e-03 | 3.19e-02 | 50 |
GO:00070092 | Cervix | CC | plasma membrane organization | 28/2311 | 142/18723 | 7.85e-03 | 4.14e-02 | 28 |
GO:004206025 | Cervix | N_HPV | wound healing | 28/534 | 422/18723 | 3.37e-05 | 8.58e-04 | 28 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:00420601 | Colorectum | SER | wound healing | 97/2897 | 422/18723 | 2.69e-05 | 7.30e-04 | 97 |
GO:0007009 | Colorectum | SER | plasma membrane organization | 36/2897 | 142/18723 | 1.50e-03 | 1.62e-02 | 36 |
GO:0003012 | Colorectum | SER | muscle system process | 92/2897 | 452/18723 | 2.98e-03 | 2.63e-02 | 92 |
GO:00420602 | Colorectum | MSS | wound healing | 119/3467 | 422/18723 | 5.93e-07 | 2.24e-05 | 119 |
GO:00030121 | Colorectum | MSS | muscle system process | 105/3467 | 452/18723 | 6.39e-03 | 4.26e-02 | 105 |
GO:00420604 | Colorectum | FAP | wound healing | 99/2622 | 422/18723 | 9.50e-08 | 6.33e-06 | 99 |
GO:00030122 | Colorectum | FAP | muscle system process | 89/2622 | 452/18723 | 4.63e-04 | 5.39e-03 | 89 |
GO:00070091 | Colorectum | FAP | plasma membrane organization | 31/2622 | 142/18723 | 7.20e-03 | 4.38e-02 | 31 |
GO:004206016 | Endometrium | AEH | wound healing | 91/2100 | 422/18723 | 4.85e-10 | 4.61e-08 | 91 |
GO:00030126 | Endometrium | AEH | muscle system process | 78/2100 | 452/18723 | 6.89e-05 | 1.06e-03 | 78 |
GO:00426925 | Endometrium | AEH | muscle cell differentiation | 68/2100 | 384/18723 | 8.88e-05 | 1.30e-03 | 68 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYOF | SNV | Missense_Mutation | c.5546N>C | p.Val1849Ala | p.V1849A | Q9NZM1 | protein_coding | deleterious(0) | possibly_damaging(0.906) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYOF | SNV | Missense_Mutation | rs761081912 | c.6089N>A | p.Gly2030Asp | p.G2030D | Q9NZM1 | protein_coding | tolerated(0.13) | benign(0.406) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYOF | SNV | Missense_Mutation | c.2954A>G | p.Asn985Ser | p.N985S | Q9NZM1 | protein_coding | tolerated(0.07) | benign(0.167) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MYOF | SNV | Missense_Mutation | novel | c.26C>T | p.Ala9Val | p.A9V | Q9NZM1 | protein_coding | deleterious(0) | possibly_damaging(0.788) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MYOF | SNV | Missense_Mutation | c.3508C>A | p.His1170Asn | p.H1170N | Q9NZM1 | protein_coding | tolerated(0.13) | probably_damaging(0.95) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYOF | SNV | Missense_Mutation | novel | c.3878N>C | p.Val1293Ala | p.V1293A | Q9NZM1 | protein_coding | deleterious(0) | possibly_damaging(0.452) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYOF | SNV | Missense_Mutation | c.3070N>T | p.Val1024Phe | p.V1024F | Q9NZM1 | protein_coding | deleterious(0) | benign(0.378) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYOF | SNV | Missense_Mutation | rs771328774 | c.1273N>A | p.Val425Ile | p.V425I | Q9NZM1 | protein_coding | tolerated(0.81) | benign(0.003) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYOF | SNV | Missense_Mutation | c.1116N>T | p.Gln372His | p.Q372H | Q9NZM1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MYOF | SNV | Missense_Mutation | novel | c.2645N>A | p.Arg882His | p.R882H | Q9NZM1 | protein_coding | tolerated(0.19) | benign(0.189) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |