GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:003134611 | Liver | HCC | positive regulation of cell projection organization | 193/7958 | 353/18723 | 2.28e-06 | 3.08e-05 | 193 |
GO:001072011 | Liver | HCC | positive regulation of cell development | 155/7958 | 298/18723 | 5.39e-04 | 3.48e-03 | 155 |
GO:006056011 | Liver | HCC | developmental growth involved in morphogenesis | 124/7958 | 234/18723 | 7.37e-04 | 4.47e-03 | 124 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:004867511 | Liver | HCC | axon extension | 67/7958 | 120/18723 | 2.17e-03 | 1.09e-02 | 67 |
GO:199013811 | Liver | HCC | neuron projection extension | 92/7958 | 172/18723 | 2.31e-03 | 1.14e-02 | 92 |
GO:004858811 | Liver | HCC | developmental cell growth | 121/7958 | 234/18723 | 2.68e-03 | 1.28e-02 | 121 |
GO:00507674 | Liver | HCC | regulation of neurogenesis | 181/7958 | 364/18723 | 3.00e-03 | 1.40e-02 | 181 |
GO:004577321 | Liver | HCC | positive regulation of axon extension | 27/7958 | 42/18723 | 3.60e-03 | 1.60e-02 | 27 |
GO:00507693 | Liver | HCC | positive regulation of neurogenesis | 116/7958 | 225/18723 | 3.67e-03 | 1.63e-02 | 116 |
GO:003030711 | Liver | HCC | positive regulation of cell growth | 88/7958 | 166/18723 | 3.95e-03 | 1.74e-02 | 88 |
GO:00083614 | Liver | HCC | regulation of cell size | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
GO:00305164 | Liver | HCC | regulation of axon extension | 52/7958 | 95/18723 | 1.07e-02 | 3.97e-02 | 52 |
GO:000166721 | Liver | HCC | ameboidal-type cell migration | 226/7958 | 475/18723 | 1.35e-02 | 4.81e-02 | 226 |
GO:004592711 | Liver | HCC | positive regulation of growth | 128/7958 | 259/18723 | 1.41e-02 | 4.99e-02 | 128 |
GO:0016049112 | Thyroid | PTC | cell growth | 225/5968 | 482/18723 | 4.75e-12 | 2.07e-10 | 225 |
GO:0031346110 | Thyroid | PTC | positive regulation of cell projection organization | 173/5968 | 353/18723 | 1.09e-11 | 4.40e-10 | 173 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MEGF8 | SNV | Missense_Mutation | rs750058084 | c.7171N>A | p.Glu2391Lys | p.E2391K | Q7Z7M0 | protein_coding | tolerated(0.05) | possibly_damaging(0.833) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MEGF8 | deletion | Frame_Shift_Del | | c.7631delN | p.Ala2546LeufsTer29 | p.A2546Lfs*29 | Q7Z7M0 | protein_coding | | | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
MEGF8 | deletion | Frame_Shift_Del | novel | c.6436delN | p.Gly2147ValfsTer16 | p.G2147Vfs*16 | Q7Z7M0 | protein_coding | | | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MEGF8 | insertion | In_Frame_Ins | novel | c.278_279insGTTTTCTCTGTACTTAATTTTCCCATCTGAATGGTGGGAGTGTTCATT | p.Ser93_Pro94insPheSerLeuTyrLeuIlePheProSerGluTrpTrpGluCysSerPhe | p.S93_P94insFSLYLIFPSEWWECSF | Q7Z7M0 | protein_coding | | | TCGA-B5-A0K1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MEGF8 | deletion | Frame_Shift_Del | novel | c.3387delN | p.Pro1131ArgfsTer9 | p.P1131Rfs*9 | Q7Z7M0 | protein_coding | | | TCGA-BG-A0M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MEGF8 | deletion | Frame_Shift_Del | | c.6422delN | p.Gly2143AlafsTer20 | p.G2143Afs*20 | Q7Z7M0 | protein_coding | | | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MEGF8 | deletion | Frame_Shift_Del | | c.1593delG | p.Tyr532ThrfsTer9 | p.Y532Tfs*9 | Q7Z7M0 | protein_coding | | | TCGA-BS-A0TA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
MEGF8 | insertion | Frame_Shift_Ins | novel | c.2961_2962insG | p.Cys990LeufsTer25 | p.C990Lfs*25 | Q7Z7M0 | protein_coding | | | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MEGF8 | deletion | Frame_Shift_Del | | c.1588delN | p.Tyr532ThrfsTer9 | p.Y532Tfs*9 | Q7Z7M0 | protein_coding | | | TCGA-D1-A1NY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
MEGF8 | insertion | Frame_Shift_Ins | novel | c.6421_6422insG | p.Gln2144ProfsTer17 | p.Q2144Pfs*17 | Q7Z7M0 | protein_coding | | | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |