![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: JARID2 |
Gene summary for JARID2 |
![]() |
Gene information | Species | Human | Gene symbol | JARID2 | Gene ID | 3720 |
Gene name | jumonji and AT-rich interaction domain containing 2 | |
Gene Alias | JMJ | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q92833 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3720 | JARID2 | N_HPV_2 | Human | Cervix | N_HPV | 5.19e-03 | 1.39e-01 | -0.0131 |
3720 | JARID2 | CCI_1 | Human | Cervix | CC | 8.70e-15 | 1.62e+00 | 0.528 |
3720 | JARID2 | CCI_2 | Human | Cervix | CC | 3.84e-18 | 2.48e+00 | 0.5249 |
3720 | JARID2 | CCI_3 | Human | Cervix | CC | 1.45e-18 | 1.18e+00 | 0.516 |
3720 | JARID2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.21e-19 | -5.20e-01 | 0.0155 |
3720 | JARID2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.15e-06 | -5.22e-01 | -0.1808 |
3720 | JARID2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.80e-05 | -3.18e-01 | -0.1088 |
3720 | JARID2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.32e-06 | -5.78e-01 | -0.1207 |
3720 | JARID2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.26e-02 | -4.21e-01 | -0.1706 |
3720 | JARID2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.26e-02 | -6.46e-01 | -0.2061 |
3720 | JARID2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.10e-03 | -6.39e-01 | -0.1462 |
3720 | JARID2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.54e-08 | -3.33e-01 | -0.0842 |
3720 | JARID2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.59e-02 | -4.72e-01 | 0.0528 |
3720 | JARID2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.46e-12 | -4.29e-01 | 0.294 |
3720 | JARID2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.40e-02 | 5.55e-01 | 0.281 |
3720 | JARID2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.31e-09 | -5.01e-01 | 0.3005 |
3720 | JARID2 | A001-C-207 | Human | Colorectum | FAP | 2.91e-02 | -2.62e-01 | 0.1278 |
3720 | JARID2 | A015-C-203 | Human | Colorectum | FAP | 1.11e-30 | -4.61e-01 | -0.1294 |
3720 | JARID2 | A015-C-204 | Human | Colorectum | FAP | 6.97e-07 | -4.21e-01 | -0.0228 |
3720 | JARID2 | A014-C-040 | Human | Colorectum | FAP | 1.02e-05 | -5.93e-01 | -0.1184 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00147064 | Cervix | CC | striated muscle tissue development | 72/2311 | 384/18723 | 1.76e-04 | 2.07e-03 | 72 |
GO:00610089 | Cervix | CC | hepaticobiliary system development | 34/2311 | 150/18723 | 2.92e-04 | 3.14e-03 | 34 |
GO:00018899 | Cervix | CC | liver development | 33/2311 | 147/18723 | 4.27e-04 | 4.30e-03 | 33 |
GO:0033002 | Cervix | CC | muscle cell proliferation | 49/2311 | 248/18723 | 5.43e-04 | 5.24e-03 | 49 |
GO:00349685 | Cervix | CC | histone lysine methylation | 27/2311 | 115/18723 | 6.61e-04 | 6.09e-03 | 27 |
GO:00486386 | Cervix | CC | regulation of developmental growth | 61/2311 | 330/18723 | 7.69e-04 | 6.85e-03 | 61 |
GO:00310565 | Cervix | CC | regulation of histone modification | 33/2311 | 152/18723 | 7.97e-04 | 7.00e-03 | 33 |
GO:00165715 | Cervix | CC | histone methylation | 30/2311 | 141/18723 | 1.88e-03 | 1.39e-02 | 30 |
GO:19908234 | Cervix | CC | response to leukemia inhibitory factor | 22/2311 | 95/18723 | 2.40e-03 | 1.70e-02 | 22 |
GO:00180224 | Cervix | CC | peptidyl-lysine methylation | 28/2311 | 131/18723 | 2.43e-03 | 1.71e-02 | 28 |
GO:00064795 | Cervix | CC | protein methylation | 36/2311 | 181/18723 | 2.46e-03 | 1.71e-02 | 36 |
GO:00082135 | Cervix | CC | protein alkylation | 36/2311 | 181/18723 | 2.46e-03 | 1.71e-02 | 36 |
GO:00148963 | Cervix | CC | muscle hypertrophy | 23/2311 | 104/18723 | 3.63e-03 | 2.32e-02 | 23 |
GO:0014855 | Cervix | CC | striated muscle cell proliferation | 18/2311 | 76/18723 | 4.45e-03 | 2.71e-02 | 18 |
GO:19908304 | Cervix | CC | cellular response to leukemia inhibitory factor | 21/2311 | 94/18723 | 4.68e-03 | 2.82e-02 | 21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JARID2 | insertion | Frame_Shift_Ins | novel | c.3209_3210insA | p.Glu1073ArgfsTer15 | p.E1073Rfs*15 | Q92833 | protein_coding | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
JARID2 | deletion | Frame_Shift_Del | c.1266delN | p.Arg425GlyfsTer36 | p.R425Gfs*36 | Q92833 | protein_coding | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
JARID2 | deletion | Frame_Shift_Del | c.1266delN | p.Arg425GlyfsTer36 | p.R425Gfs*36 | Q92833 | protein_coding | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
JARID2 | deletion | Frame_Shift_Del | c.1266delN | p.Arg425GlyfsTer36 | p.R425Gfs*36 | Q92833 | protein_coding | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR | |||
JARID2 | deletion | Frame_Shift_Del | c.1266delN | p.Arg425GlyfsTer36 | p.R425Gfs*36 | Q92833 | protein_coding | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
JARID2 | SNV | Missense_Mutation | novel | c.1149T>G | p.Asn383Lys | p.N383K | Q92833 | protein_coding | tolerated_low_confidence(0.1) | benign(0.395) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
JARID2 | insertion | Frame_Shift_Ins | novel | c.1147_1148insGAAGCAG | p.Asn383ArgfsTer40 | p.N383Rfs*40 | Q92833 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
JARID2 | insertion | In_Frame_Ins | novel | c.2618_2619insGAACAGACG | p.His873delinsGlnAsnArgArg | p.H873delinsQNRR | Q92833 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |