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Gene: GRM8 |
Gene summary for GRM8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GRM8 | Gene ID | 2918 |
Gene name | glutamate metabotropic receptor 8 | |
Gene Alias | GLUR8 | |
Cytomap | 7q31.33 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O00222 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2918 | GRM8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.15e-03 | 6.54e-01 | -0.0811 |
2918 | GRM8 | HTA11_78_2000001011 | Human | Colorectum | AD | 9.09e-05 | 8.37e-01 | -0.1088 |
2918 | GRM8 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.85e-02 | 4.24e-01 | -0.1001 |
2918 | GRM8 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.87e-05 | 4.38e-01 | 0.0674 |
2918 | GRM8 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.59e-09 | 1.13e+00 | 0.0112 |
2918 | GRM8 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.25e-25 | 1.50e+00 | 0.0588 |
2918 | GRM8 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.65e-18 | 1.60e+00 | 0.281 |
2918 | GRM8 | A002-C-010 | Human | Colorectum | FAP | 2.99e-08 | 5.97e-01 | 0.242 |
2918 | GRM8 | A001-C-207 | Human | Colorectum | FAP | 1.32e-11 | 7.95e-01 | 0.1278 |
2918 | GRM8 | A015-C-204 | Human | Colorectum | FAP | 6.52e-04 | 5.19e-01 | -0.0228 |
2918 | GRM8 | A002-C-203 | Human | Colorectum | FAP | 2.36e-07 | 4.76e-01 | 0.2786 |
2918 | GRM8 | A001-C-108 | Human | Colorectum | FAP | 6.60e-07 | 5.24e-01 | -0.0272 |
2918 | GRM8 | A001-C-104 | Human | Colorectum | FAP | 8.00e-23 | 8.57e-01 | 0.0184 |
2918 | GRM8 | A015-C-106 | Human | Colorectum | FAP | 3.63e-13 | 6.75e-01 | -0.0511 |
2918 | GRM8 | A015-C-104 | Human | Colorectum | FAP | 1.14e-02 | -5.67e-02 | -0.1899 |
2918 | GRM8 | A015-C-202 | Human | Colorectum | FAP | 1.17e-11 | 6.09e-01 | -0.0849 |
2918 | GRM8 | A001-C-014 | Human | Colorectum | FAP | 8.86e-14 | 7.05e-01 | 0.0135 |
2918 | GRM8 | A002-C-016 | Human | Colorectum | FAP | 7.23e-03 | 2.56e-01 | 0.0521 |
2918 | GRM8 | A015-C-002 | Human | Colorectum | FAP | 6.03e-13 | 8.13e-01 | -0.0763 |
2918 | GRM8 | A001-C-203 | Human | Colorectum | FAP | 1.08e-04 | 4.89e-01 | -0.0481 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04724 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
hsa047241 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRM8 | SNV | Missense_Mutation | c.1166G>C | p.Arg389Pro | p.R389P | O00222 | protein_coding | deleterious(0.01) | benign(0.112) | TCGA-46-3766-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | novel | c.1548N>G | p.Cys516Trp | p.C516W | O00222 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
GRM8 | SNV | Missense_Mutation | novel | c.1331N>T | p.Gly444Val | p.G444V | O00222 | protein_coding | deleterious(0.02) | benign(0.102) | TCGA-56-7582-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GRM8 | SNV | Missense_Mutation | novel | c.2323G>C | p.Glu775Gln | p.E775Q | O00222 | protein_coding | deleterious(0) | possibly_damaging(0.854) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GRM8 | SNV | Missense_Mutation | novel | c.2396N>A | p.Pro799His | p.P799H | O00222 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-58-8392-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GRM8 | SNV | Missense_Mutation | novel | c.231G>T | p.Glu77Asp | p.E77D | O00222 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-58-A46L-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
GRM8 | SNV | Missense_Mutation | c.2139N>T | p.Trp713Cys | p.W713C | O00222 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-63-6202-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | novel | c.2223N>T | p.Lys741Asn | p.K741N | O00222 | protein_coding | deleterious(0) | benign(0.145) | TCGA-63-7023-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unspecific | Vinorelbine Tartrate | SD |
GRM8 | SNV | Missense_Mutation | novel | c.2063N>G | p.Lys688Arg | p.K688R | O00222 | protein_coding | tolerated(1) | benign(0.003) | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
GRM8 | SNV | Missense_Mutation | novel | c.1123N>C | p.Gly375Arg | p.G375R | O00222 | protein_coding | tolerated(0.12) | benign(0.102) | TCGA-63-A5MI-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | vinorelbine | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650554 | EGLUMEGAD | |
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135650552 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 178102837 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651136 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 381744920 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650507 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651511 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650159 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651501 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650510 |
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