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Gene: CTNNA3 |
Gene summary for CTNNA3 |
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Gene information | Species | Human | Gene symbol | CTNNA3 | Gene ID | 29119 |
Gene name | catenin alpha 3 | |
Gene Alias | ARVD13 | |
Cytomap | 10q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | A8K141 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29119 | CTNNA3 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.73e-05 | 2.68e-01 | -0.1954 |
29119 | CTNNA3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.64e-04 | 3.84e-01 | -0.1207 |
29119 | CTNNA3 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.69e-03 | 2.78e-01 | -0.1526 |
29119 | CTNNA3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.00e-06 | 3.10e-01 | -0.1464 |
29119 | CTNNA3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.43e-02 | 1.53e-01 | -0.1001 |
29119 | CTNNA3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.76e-05 | 2.77e-01 | -0.059 |
29119 | CTNNA3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.87e-03 | 3.78e-01 | -0.1706 |
29119 | CTNNA3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.70e-03 | 4.45e-01 | 0.0112 |
29119 | CTNNA3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.94e-04 | 5.88e-01 | 0.3487 |
29119 | CTNNA3 | AEH-subject1 | Human | Endometrium | AEH | 1.66e-03 | 1.17e-01 | -0.3059 |
29119 | CTNNA3 | HTA12-23-1 | Human | Pancreas | PDAC | 3.41e-03 | 5.19e-01 | 0.3405 |
29119 | CTNNA3 | HTA12-26-1 | Human | Pancreas | PDAC | 9.77e-13 | 6.82e-01 | 0.3728 |
29119 | CTNNA3 | HTA12-29-1 | Human | Pancreas | PDAC | 3.38e-23 | 6.11e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0034109 | Colorectum | AD | homotypic cell-cell adhesion | 40/3918 | 90/18723 | 4.37e-07 | 1.67e-05 | 40 |
GO:0098901 | Colorectum | AD | regulation of cardiac muscle cell action potential | 15/3918 | 27/18723 | 8.20e-05 | 1.29e-03 | 15 |
GO:0098911 | Colorectum | AD | regulation of ventricular cardiac muscle cell action potential | 9/3918 | 12/18723 | 9.01e-05 | 1.38e-03 | 9 |
GO:0030048 | Colorectum | AD | actin filament-based movement | 44/3918 | 127/18723 | 2.31e-04 | 2.99e-03 | 44 |
GO:0090257 | Colorectum | AD | regulation of muscle system process | 73/3918 | 252/18723 | 1.46e-03 | 1.24e-02 | 73 |
GO:0086004 | Colorectum | AD | regulation of cardiac muscle cell contraction | 15/3918 | 34/18723 | 1.96e-03 | 1.58e-02 | 15 |
GO:00070151 | Colorectum | SER | actin filament organization | 134/2897 | 442/18723 | 1.39e-15 | 5.70e-13 | 134 |
GO:00329701 | Colorectum | SER | regulation of actin filament-based process | 115/2897 | 397/18723 | 4.16e-12 | 8.80e-10 | 115 |
GO:00341091 | Colorectum | SER | homotypic cell-cell adhesion | 32/2897 | 90/18723 | 2.23e-06 | 9.31e-05 | 32 |
GO:00300481 | Colorectum | SER | actin filament-based movement | 38/2897 | 127/18723 | 2.80e-05 | 7.56e-04 | 38 |
GO:00989011 | Colorectum | SER | regulation of cardiac muscle cell action potential | 12/2897 | 27/18723 | 3.27e-04 | 5.22e-03 | 12 |
GO:00902571 | Colorectum | SER | regulation of muscle system process | 60/2897 | 252/18723 | 3.28e-04 | 5.22e-03 | 60 |
GO:00989111 | Colorectum | SER | regulation of ventricular cardiac muscle cell action potential | 7/2897 | 12/18723 | 8.12e-04 | 1.01e-02 | 7 |
GO:0003012 | Colorectum | SER | muscle system process | 92/2897 | 452/18723 | 2.98e-03 | 2.63e-02 | 92 |
GO:00860041 | Colorectum | SER | regulation of cardiac muscle cell contraction | 12/2897 | 34/18723 | 3.60e-03 | 3.03e-02 | 12 |
GO:0055117 | Colorectum | SER | regulation of cardiac muscle contraction | 21/2897 | 77/18723 | 5.54e-03 | 4.09e-02 | 21 |
GO:00341093 | Colorectum | MSI-H | homotypic cell-cell adhesion | 20/1319 | 90/18723 | 3.43e-06 | 1.89e-04 | 20 |
GO:00329703 | Colorectum | MSI-H | regulation of actin filament-based process | 49/1319 | 397/18723 | 8.99e-05 | 2.90e-03 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa05213 | Colorectum | AD | Endometrial cancer | 29/2092 | 58/8465 | 2.69e-05 | 2.57e-04 | 1.64e-04 | 29 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa052131 | Colorectum | AD | Endometrial cancer | 29/2092 | 58/8465 | 2.69e-05 | 2.57e-04 | 1.64e-04 | 29 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa046702 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa052132 | Colorectum | SER | Endometrial cancer | 20/1580 | 58/8465 | 3.05e-03 | 2.11e-02 | 1.53e-02 | 20 |
hsa051003 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa046703 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa052133 | Colorectum | SER | Endometrial cancer | 20/1580 | 58/8465 | 3.05e-03 | 2.11e-02 | 1.53e-02 | 20 |
hsa045206 | Colorectum | MSI-H | Adherens junction | 22/797 | 93/8465 | 3.71e-05 | 5.47e-04 | 4.58e-04 | 22 |
hsa051006 | Colorectum | MSI-H | Bacterial invasion of epithelial cells | 15/797 | 77/8465 | 4.86e-03 | 4.63e-02 | 3.88e-02 | 15 |
hsa045207 | Colorectum | MSI-H | Adherens junction | 22/797 | 93/8465 | 3.71e-05 | 5.47e-04 | 4.58e-04 | 22 |
hsa051007 | Colorectum | MSI-H | Bacterial invasion of epithelial cells | 15/797 | 77/8465 | 4.86e-03 | 4.63e-02 | 3.88e-02 | 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTNNA3 | SNV | Missense_Mutation | c.1645N>T | p.His549Tyr | p.H549Y | Q9UI47 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-BR-8679-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CTNNA3 | SNV | Missense_Mutation | c.2374N>A | p.Leu792Met | p.L792M | Q9UI47 | protein_coding | deleterious(0.01) | benign(0.203) | TCGA-BR-A4J4-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CTNNA3 | SNV | Missense_Mutation | c.1247N>T | p.Ala416Val | p.A416V | Q9UI47 | protein_coding | tolerated(0.1) | benign(0.125) | TCGA-D7-6526-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
CTNNA3 | SNV | Missense_Mutation | novel | c.201N>T | p.Trp67Cys | p.W67C | Q9UI47 | protein_coding | tolerated(0.06) | possibly_damaging(0.819) | TCGA-D7-A6EX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CTNNA3 | SNV | Missense_Mutation | c.1089N>T | p.Leu363Phe | p.L363F | Q9UI47 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-EQ-A4SO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
CTNNA3 | SNV | Missense_Mutation | novel | c.972C>G | p.His324Gln | p.H324Q | Q9UI47 | protein_coding | deleterious(0.01) | possibly_damaging(0.682) | TCGA-HF-7134-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
CTNNA3 | SNV | Missense_Mutation | rs773609785 | c.974N>A | p.Arg325Gln | p.R325Q | Q9UI47 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
CTNNA3 | SNV | Missense_Mutation | c.892N>T | p.Pro298Ser | p.P298S | Q9UI47 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CTNNA3 | SNV | Missense_Mutation | c.263N>T | p.Thr88Met | p.T88M | Q9UI47 | protein_coding | tolerated(0.26) | benign(0.011) | TCGA-HU-A4H2-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CTNNA3 | SNV | Missense_Mutation | c.1982N>C | p.Lys661Thr | p.K661T | Q9UI47 | protein_coding | tolerated(0.16) | benign(0.113) | TCGA-HU-A4HD-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
29119 | CTNNA3 | NA | antidepressants |
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