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Gene: CEP170 |
Gene summary for CEP170 |
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Gene information | Species | Human | Gene symbol | CEP170 | Gene ID | 9859 |
Gene name | centrosomal protein 170 | |
Gene Alias | FAM68A | |
Cytomap | 1q43 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5SW79 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9859 | CEP170 | LZE2T | Human | Esophagus | ESCC | 8.29e-04 | 6.43e-01 | 0.082 |
9859 | CEP170 | LZE4T | Human | Esophagus | ESCC | 2.65e-12 | 2.56e-01 | 0.0811 |
9859 | CEP170 | LZE7T | Human | Esophagus | ESCC | 1.69e-12 | 9.27e-01 | 0.0667 |
9859 | CEP170 | LZE8T | Human | Esophagus | ESCC | 3.94e-03 | 1.04e-01 | 0.067 |
9859 | CEP170 | LZE21D1 | Human | Esophagus | HGIN | 3.33e-03 | 2.11e-01 | 0.0632 |
9859 | CEP170 | LZE22T | Human | Esophagus | ESCC | 1.01e-05 | 4.14e-01 | 0.068 |
9859 | CEP170 | LZE24T | Human | Esophagus | ESCC | 7.19e-15 | 2.65e-01 | 0.0596 |
9859 | CEP170 | P2T-E | Human | Esophagus | ESCC | 1.06e-28 | 4.82e-01 | 0.1177 |
9859 | CEP170 | P4T-E | Human | Esophagus | ESCC | 1.39e-13 | 2.82e-01 | 0.1323 |
9859 | CEP170 | P5T-E | Human | Esophagus | ESCC | 3.97e-17 | 3.65e-01 | 0.1327 |
9859 | CEP170 | P8T-E | Human | Esophagus | ESCC | 1.18e-06 | 1.46e-01 | 0.0889 |
9859 | CEP170 | P9T-E | Human | Esophagus | ESCC | 9.19e-14 | 2.32e-01 | 0.1131 |
9859 | CEP170 | P10T-E | Human | Esophagus | ESCC | 2.65e-19 | 3.44e-01 | 0.116 |
9859 | CEP170 | P11T-E | Human | Esophagus | ESCC | 3.84e-10 | 4.86e-01 | 0.1426 |
9859 | CEP170 | P12T-E | Human | Esophagus | ESCC | 3.08e-25 | 5.10e-01 | 0.1122 |
9859 | CEP170 | P15T-E | Human | Esophagus | ESCC | 1.57e-16 | 3.87e-01 | 0.1149 |
9859 | CEP170 | P16T-E | Human | Esophagus | ESCC | 6.79e-34 | 6.78e-01 | 0.1153 |
9859 | CEP170 | P17T-E | Human | Esophagus | ESCC | 5.05e-04 | 2.92e-01 | 0.1278 |
9859 | CEP170 | P19T-E | Human | Esophagus | ESCC | 6.94e-09 | 6.69e-01 | 0.1662 |
9859 | CEP170 | P20T-E | Human | Esophagus | ESCC | 2.08e-11 | 3.00e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP170 | SNV | Missense_Mutation | c.1267N>T | p.Ala423Ser | p.A423S | Q5SW79 | protein_coding | tolerated(0.98) | benign(0.012) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CEP170 | SNV | Missense_Mutation | novel | c.2926N>A | p.Val976Ile | p.V976I | Q5SW79 | protein_coding | tolerated_low_confidence(0.12) | benign(0.119) | TCGA-56-7582-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CEP170 | SNV | Missense_Mutation | novel | c.1994A>T | p.Gln665Leu | p.Q665L | Q5SW79 | protein_coding | tolerated(0.36) | benign(0) | TCGA-56-8622-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CEP170 | SNV | Missense_Mutation | novel | c.211N>T | p.Val71Leu | p.V71L | Q5SW79 | protein_coding | deleterious(0) | benign(0.213) | TCGA-56-A4BY-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CEP170 | SNV | Missense_Mutation | novel | c.1294G>T | p.Gly432Trp | p.G432W | Q5SW79 | protein_coding | deleterious(0) | possibly_damaging(0.533) | TCGA-58-A46L-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
CEP170 | SNV | Missense_Mutation | c.1877N>T | p.Arg626Ile | p.R626I | Q5SW79 | protein_coding | deleterious(0.01) | benign(0.379) | TCGA-60-2722-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD | |
CEP170 | SNV | Missense_Mutation | rs772579241 | c.2257C>A | p.Gln753Lys | p.Q753K | Q5SW79 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-63-6202-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
CEP170 | SNV | Missense_Mutation | novel | c.3005N>T | p.Arg1002Ile | p.R1002I | Q5SW79 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-63-A5MJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vinorelbine | SD |
CEP170 | SNV | Missense_Mutation | novel | c.4434N>T | p.Gln1478His | p.Q1478H | Q5SW79 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-63-A5MT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
CEP170 | SNV | Missense_Mutation | novel | c.4021N>T | p.Ala1341Ser | p.A1341S | Q5SW79 | protein_coding | tolerated(0.11) | probably_damaging(0.989) | TCGA-85-7710-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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