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Gene: BRINP3 |
Gene summary for BRINP3 |
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Gene information | Species | Human | Gene symbol | BRINP3 | Gene ID | 339479 |
Gene name | BMP/retinoic acid inducible neural specific 3 | |
Gene Alias | DBCCR1L | |
Cytomap | 1q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q76B58 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339479 | BRINP3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.85e-39 | -1.05e+00 | 0.0155 |
339479 | BRINP3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.04e-06 | -1.04e+00 | 0.0216 |
339479 | BRINP3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.43e-15 | -9.73e-01 | -0.0811 |
339479 | BRINP3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.93e-04 | -9.66e-01 | -0.2196 |
339479 | BRINP3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.02e-10 | -7.97e-01 | -0.1207 |
339479 | BRINP3 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.17e-25 | -6.57e-01 | -0.1464 |
339479 | BRINP3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.29e-20 | -6.60e-01 | -0.1001 |
339479 | BRINP3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.33e-24 | -9.12e-01 | -0.059 |
339479 | BRINP3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.44e-05 | -9.12e-01 | -0.1706 |
339479 | BRINP3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.06e-03 | -7.40e-01 | -0.1462 |
339479 | BRINP3 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.48e-05 | -6.87e-01 | -0.0842 |
339479 | BRINP3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.80e-08 | -5.33e-01 | -0.0179 |
339479 | BRINP3 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.49e-36 | -1.06e+00 | 0.096 |
339479 | BRINP3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.39e-02 | -8.53e-01 | 0.0446 |
339479 | BRINP3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.14e-05 | -1.08e+00 | 0.0451 |
339479 | BRINP3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.04e-09 | -1.03e+00 | 0.0528 |
339479 | BRINP3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.29e-03 | -8.06e-01 | 0.0171 |
339479 | BRINP3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.01e-17 | -9.51e-01 | 0.0338 |
339479 | BRINP3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.28e-62 | -1.06e+00 | 0.0674 |
339479 | BRINP3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.47e-11 | -1.05e+00 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:00073461 | Colorectum | MSS | regulation of mitotic cell cycle | 108/3467 | 457/18723 | 3.30e-03 | 2.50e-02 | 108 |
GO:00073462 | Colorectum | FAP | regulation of mitotic cell cycle | 85/2622 | 457/18723 | 3.41e-03 | 2.48e-02 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRINP3 | SNV | Missense_Mutation | c.1909N>A | p.Gly637Ser | p.G637S | Q76B58 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-93-A4JQ-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BRINP3 | SNV | Missense_Mutation | c.1642N>T | p.His548Tyr | p.H548Y | Q76B58 | protein_coding | deleterious(0) | possibly_damaging(0.775) | TCGA-95-A4VK-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
BRINP3 | SNV | Missense_Mutation | c.1817N>T | p.Gln606Leu | p.Q606L | Q76B58 | protein_coding | deleterious(0) | benign(0.074) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD | |
BRINP3 | SNV | Missense_Mutation | rs201165374 | c.1370G>T | p.Arg457Leu | p.R457L | Q76B58 | protein_coding | tolerated(0.66) | benign(0) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BRINP3 | SNV | Missense_Mutation | c.167N>T | p.Arg56Leu | p.R56L | Q76B58 | protein_coding | deleterious(0.04) | benign(0.15) | TCGA-MP-A4TC-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
BRINP3 | SNV | Missense_Mutation | rs745308648 | c.1268N>T | p.Thr423Met | p.T423M | Q76B58 | protein_coding | tolerated(0.06) | benign(0.187) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BRINP3 | SNV | Missense_Mutation | c.330N>G | p.Asn110Lys | p.N110K | Q76B58 | protein_coding | deleterious(0.02) | benign(0.131) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BRINP3 | SNV | Missense_Mutation | c.928T>A | p.Trp310Arg | p.W310R | Q76B58 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
BRINP3 | SNV | Missense_Mutation | novel | c.1595N>T | p.Arg532Leu | p.R532L | Q76B58 | protein_coding | tolerated(0.11) | probably_damaging(0.931) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
BRINP3 | SNV | Missense_Mutation | c.1685N>C | p.Asn562Thr | p.N562T | Q76B58 | protein_coding | tolerated(0.05) | probably_damaging(0.956) | TCGA-18-3419-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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