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Gene: ZNF521 |
Gene summary for ZNF521 |
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Gene information | Species | Human | Gene symbol | ZNF521 | Gene ID | 25925 |
Gene name | zinc finger protein 521 | |
Gene Alias | EHZF | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | J3KTI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25925 | ZNF521 | ATC12 | Human | Thyroid | ATC | 2.71e-08 | 1.55e-01 | 0.34 |
25925 | ZNF521 | ATC13 | Human | Thyroid | ATC | 1.72e-28 | 5.06e-01 | 0.34 |
25925 | ZNF521 | ATC2 | Human | Thyroid | ATC | 5.35e-04 | 3.20e-01 | 0.34 |
25925 | ZNF521 | ATC4 | Human | Thyroid | ATC | 2.47e-08 | 1.87e-01 | 0.34 |
25925 | ZNF521 | ATC5 | Human | Thyroid | ATC | 1.81e-27 | 5.56e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF521 | SNV | Missense_Mutation | c.3379N>T | p.Ile1127Phe | p.I1127F | Q96K83 | protein_coding | tolerated(0.7) | benign(0.017) | TCGA-62-A46P-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF521 | SNV | Missense_Mutation | novel | c.3176A>T | p.Gln1059Leu | p.Q1059L | Q96K83 | protein_coding | deleterious_low_confidence(0.04) | benign(0) | TCGA-62-A46R-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF521 | SNV | Missense_Mutation | c.136G>T | p.Val46Leu | p.V46L | Q96K83 | protein_coding | tolerated_low_confidence(0.35) | benign(0.001) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF521 | SNV | Missense_Mutation | c.734N>A | p.Thr245Asn | p.T245N | Q96K83 | protein_coding | tolerated(0.24) | benign(0.313) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF521 | SNV | Missense_Mutation | c.3146G>A | p.Gly1049Glu | p.G1049E | Q96K83 | protein_coding | tolerated(0.07) | benign(0.083) | TCGA-73-4677-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF521 | SNV | Missense_Mutation | novel | c.1734N>G | p.Asn578Lys | p.N578K | Q96K83 | protein_coding | tolerated(0.36) | benign(0.366) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
ZNF521 | SNV | Missense_Mutation | novel | c.368N>T | p.Cys123Phe | p.C123F | Q96K83 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
ZNF521 | SNV | Missense_Mutation | c.1087C>G | p.Leu363Val | p.L363V | Q96K83 | protein_coding | tolerated_low_confidence(0.49) | benign(0.387) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD | |
ZNF521 | SNV | Missense_Mutation | c.2963N>C | p.Gly988Ala | p.G988A | Q96K83 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
ZNF521 | SNV | Missense_Mutation | c.3238N>A | p.Leu1080Met | p.L1080M | Q96K83 | protein_coding | tolerated(0.06) | possibly_damaging(0.897) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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