Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ZNF407_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ZNF407_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ZNF407_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ZNF407_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZNF407_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ZNF407_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF407 | PERI | Colorectum | MSI-H | PTPRM,ANKRD12,ATP9B, etc. | 2.40e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSI-H/regulons_activity_in_dotplot.png) |
ZNF407 | CD8TEXP | Prostate | ADJ | ZDHHC21,UTRN,FAM172A, etc. | 3.25e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF407 | CD8TCM | Prostate | BPH | ZDHHC21,UTRN,FAM172A, etc. | 2.53e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_BPH/regulons_activity_in_dotplot.png) |
ZNF407 | BN | Prostate | Healthy | ZDHHC21,UTRN,FAM172A, etc. | 3.18e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF407 | BN | Prostate | Tumor | ZDHHC21,UTRN,FAM172A, etc. | 1.09e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Tumor/regulons_activity_in_dotplot.png) |
ZNF407 | MSC | Prostate | Healthy | TRAK1,DNAJC27,EBF1, etc. | 8.14e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF407 | SNV | Missense_Mutation | novel | c.2647G>T | p.Val883Leu | p.V883L | Q9C0G0 | protein_coding | tolerated(0.2) | benign(0.402) | TCGA-22-A5C4-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.1136G>T | p.Ser379Ile | p.S379I | Q9C0G0 | protein_coding | deleterious(0.03) | benign(0.216) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | rs746378777 | c.119T>A | p.Ile40Lys | p.I40K | Q9C0G0 | protein_coding | tolerated_low_confidence(0.88) | benign(0) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | | c.110N>T | p.Ser37Phe | p.S37F | Q9C0G0 | protein_coding | tolerated_low_confidence(0.15) | benign(0.015) | TCGA-34-5240-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
ZNF407 | SNV | Missense_Mutation | | c.799N>G | p.Thr267Ala | p.T267A | Q9C0G0 | protein_coding | deleterious(0) | possibly_damaging(0.727) | TCGA-34-5927-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.5011N>C | p.Ser1671Pro | p.S1671P | Q9C0G0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZNF407 | SNV | Missense_Mutation | | c.3617C>A | p.Ser1206Tyr | p.S1206Y | Q9C0G0 | protein_coding | tolerated(0.07) | benign(0.276) | TCGA-37-3783-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.6594N>T | p.Glu2198Asp | p.E2198D | Q9C0G0 | protein_coding | tolerated(0.16) | benign(0.028) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | | c.2823G>A | p.Met941Ile | p.M941I | Q9C0G0 | protein_coding | tolerated(0.32) | benign(0) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.1709N>T | p.Arg570Met | p.R570M | Q9C0G0 | protein_coding | deleterious(0.03) | possibly_damaging(0.533) | TCGA-43-2576-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |