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Gene: USF3 |
Gene summary for USF3 |
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Gene information | Species | Human | Gene symbol | USF3 | Gene ID | 205717 |
Gene name | upstream transcription factor family member 3 | |
Gene Alias | KIAA2018 | |
Cytomap | 3q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001837 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
205717 | USF3 | LZE24T | Human | Esophagus | ESCC | 7.38e-04 | 2.06e-01 | 0.0596 |
205717 | USF3 | P1T-E | Human | Esophagus | ESCC | 7.25e-05 | 2.88e-01 | 0.0875 |
205717 | USF3 | P2T-E | Human | Esophagus | ESCC | 8.15e-12 | 1.71e-01 | 0.1177 |
205717 | USF3 | P4T-E | Human | Esophagus | ESCC | 1.36e-05 | 1.04e-01 | 0.1323 |
205717 | USF3 | P5T-E | Human | Esophagus | ESCC | 1.89e-08 | 4.73e-02 | 0.1327 |
205717 | USF3 | P8T-E | Human | Esophagus | ESCC | 1.67e-14 | 2.44e-01 | 0.0889 |
205717 | USF3 | P10T-E | Human | Esophagus | ESCC | 1.26e-15 | 2.99e-01 | 0.116 |
205717 | USF3 | P11T-E | Human | Esophagus | ESCC | 1.08e-02 | 1.77e-01 | 0.1426 |
205717 | USF3 | P12T-E | Human | Esophagus | ESCC | 1.45e-03 | 3.06e-02 | 0.1122 |
205717 | USF3 | P15T-E | Human | Esophagus | ESCC | 7.98e-03 | 8.66e-02 | 0.1149 |
205717 | USF3 | P16T-E | Human | Esophagus | ESCC | 1.15e-14 | 1.70e-01 | 0.1153 |
205717 | USF3 | P20T-E | Human | Esophagus | ESCC | 7.24e-06 | 2.25e-01 | 0.1124 |
205717 | USF3 | P21T-E | Human | Esophagus | ESCC | 1.24e-09 | 1.23e-01 | 0.1617 |
205717 | USF3 | P22T-E | Human | Esophagus | ESCC | 1.31e-08 | 1.14e-01 | 0.1236 |
205717 | USF3 | P23T-E | Human | Esophagus | ESCC | 1.30e-14 | 2.84e-01 | 0.108 |
205717 | USF3 | P24T-E | Human | Esophagus | ESCC | 1.39e-07 | 9.64e-02 | 0.1287 |
205717 | USF3 | P26T-E | Human | Esophagus | ESCC | 2.58e-13 | 1.18e-01 | 0.1276 |
205717 | USF3 | P27T-E | Human | Esophagus | ESCC | 2.24e-15 | 1.83e-01 | 0.1055 |
205717 | USF3 | P28T-E | Human | Esophagus | ESCC | 1.92e-16 | 1.19e-01 | 0.1149 |
205717 | USF3 | P30T-E | Human | Esophagus | ESCC | 8.81e-14 | 5.20e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018378 | Esophagus | ESCC | epithelial to mesenchymal transition | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00487628 | Esophagus | ESCC | mesenchymal cell differentiation | 133/8552 | 236/18723 | 5.94e-04 | 3.22e-03 | 133 |
GO:00107174 | Esophagus | ESCC | regulation of epithelial to mesenchymal transition | 61/8552 | 99/18723 | 1.01e-03 | 5.09e-03 | 61 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:00018377 | Oral cavity | OSCC | epithelial to mesenchymal transition | 82/7305 | 157/18723 | 5.09e-04 | 2.98e-03 | 82 |
GO:00107173 | Oral cavity | OSCC | regulation of epithelial to mesenchymal transition | 54/7305 | 99/18723 | 1.21e-03 | 6.10e-03 | 54 |
GO:00487627 | Oral cavity | OSCC | mesenchymal cell differentiation | 109/7305 | 236/18723 | 1.43e-02 | 4.69e-02 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USF3 | SNV | Missense_Mutation | c.1931C>T | p.Ser644Leu | p.S644L | Q68DE3 | protein_coding | tolerated(0.07) | benign(0.341) | TCGA-18-5595-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
USF3 | SNV | Missense_Mutation | novel | c.301N>G | p.Lys101Glu | p.K101E | Q68DE3 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-21-5783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
USF3 | SNV | Missense_Mutation | rs377443949 | c.6046C>T | p.Leu2016Phe | p.L2016F | Q68DE3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-4604-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Targeted Molecular therapy | iressa | PD |
USF3 | SNV | Missense_Mutation | novel | c.5584N>T | p.His1862Tyr | p.H1862Y | Q68DE3 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.855) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
USF3 | SNV | Missense_Mutation | novel | c.712N>C | p.Glu238Gln | p.E238Q | Q68DE3 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.716) | TCGA-33-6738-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | SD |
USF3 | SNV | Missense_Mutation | novel | c.2074N>G | p.Gln692Glu | p.Q692E | Q68DE3 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-33-AASJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
USF3 | SNV | Missense_Mutation | novel | c.5381A>T | p.Tyr1794Phe | p.Y1794F | Q68DE3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
USF3 | SNV | Missense_Mutation | novel | c.4251A>T | p.Glu1417Asp | p.E1417D | Q68DE3 | protein_coding | tolerated(0.26) | benign(0.028) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
USF3 | SNV | Missense_Mutation | novel | c.4585C>A | p.Gln1529Lys | p.Q1529K | Q68DE3 | protein_coding | tolerated(0.09) | benign(0.197) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USF3 | SNV | Missense_Mutation | c.3653N>A | p.Gly1218Glu | p.G1218E | Q68DE3 | protein_coding | tolerated(0.06) | probably_damaging(0.982) | TCGA-39-5024-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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