![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TCF20 |
Gene summary for TCF20 |
![]() |
Gene information | Species | Human | Gene symbol | TCF20 | Gene ID | 6942 |
Gene name | transcription factor 20 | |
Gene Alias | AR1 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UGU0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6942 | TCF20 | CCI_1 | Human | Cervix | CC | 6.05e-09 | 6.63e-01 | 0.528 |
6942 | TCF20 | CCI_2 | Human | Cervix | CC | 1.01e-08 | 6.95e-01 | 0.5249 |
6942 | TCF20 | CCI_3 | Human | Cervix | CC | 6.08e-19 | 1.05e+00 | 0.516 |
6942 | TCF20 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.41e-03 | 5.03e-01 | -0.059 |
6942 | TCF20 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.96e-03 | 5.57e-01 | 0.3859 |
6942 | TCF20 | A001-C-207 | Human | Colorectum | FAP | 8.20e-04 | -9.44e-02 | 0.1278 |
6942 | TCF20 | A015-C-203 | Human | Colorectum | FAP | 1.62e-28 | -2.46e-01 | -0.1294 |
6942 | TCF20 | A015-C-204 | Human | Colorectum | FAP | 2.13e-07 | -1.99e-01 | -0.0228 |
6942 | TCF20 | A014-C-040 | Human | Colorectum | FAP | 9.71e-07 | -4.71e-01 | -0.1184 |
6942 | TCF20 | A002-C-201 | Human | Colorectum | FAP | 2.44e-12 | -2.26e-01 | 0.0324 |
6942 | TCF20 | A002-C-203 | Human | Colorectum | FAP | 3.78e-04 | 1.16e-01 | 0.2786 |
6942 | TCF20 | A001-C-119 | Human | Colorectum | FAP | 1.05e-06 | -1.73e-01 | -0.1557 |
6942 | TCF20 | A001-C-108 | Human | Colorectum | FAP | 3.61e-16 | -2.02e-01 | -0.0272 |
6942 | TCF20 | A002-C-205 | Human | Colorectum | FAP | 1.05e-23 | -1.86e-01 | -0.1236 |
6942 | TCF20 | A001-C-104 | Human | Colorectum | FAP | 3.17e-02 | -2.72e-02 | 0.0184 |
6942 | TCF20 | A015-C-005 | Human | Colorectum | FAP | 1.06e-03 | -1.31e-01 | -0.0336 |
6942 | TCF20 | A015-C-006 | Human | Colorectum | FAP | 8.20e-16 | -2.56e-01 | -0.0994 |
6942 | TCF20 | A015-C-106 | Human | Colorectum | FAP | 1.08e-10 | -1.33e-01 | -0.0511 |
6942 | TCF20 | A002-C-114 | Human | Colorectum | FAP | 8.93e-21 | -4.33e-01 | -0.1561 |
6942 | TCF20 | A015-C-104 | Human | Colorectum | FAP | 3.14e-33 | -3.65e-01 | -0.1899 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCF20 | SNV | Missense_Mutation | c.5630N>T | p.Glu1877Val | p.E1877V | Q9UGU0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
TCF20 | SNV | Missense_Mutation | novel | c.3284N>C | p.Glu1095Ala | p.E1095A | Q9UGU0 | protein_coding | deleterious_low_confidence(0) | benign(0.411) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCF20 | SNV | Missense_Mutation | rs759572513 | c.5504G>T | p.Gly1835Val | p.G1835V | Q9UGU0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-69-7765-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD |
TCF20 | SNV | Missense_Mutation | c.2908N>T | p.Ala970Ser | p.A970S | Q9UGU0 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.581) | TCGA-78-7158-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
TCF20 | SNV | Missense_Mutation | c.3667N>G | p.Leu1223Val | p.L1223V | Q9UGU0 | protein_coding | tolerated_low_confidence(0.15) | benign(0.15) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
TCF20 | SNV | Missense_Mutation | novel | c.5799G>T | p.Lys1933Asn | p.K1933N | Q9UGU0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TCF20 | SNV | Missense_Mutation | rs761776619 | c.4743N>T | p.Arg1581Ser | p.R1581S | Q9UGU0 | protein_coding | deleterious(0.01) | benign(0.365) | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCF20 | SNV | Missense_Mutation | c.4034N>A | p.Arg1345Gln | p.R1345Q | Q9UGU0 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
TCF20 | SNV | Missense_Mutation | novel | c.1648N>A | p.Gly550Ser | p.G550S | Q9UGU0 | protein_coding | tolerated_low_confidence(0.09) | benign(0.311) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TCF20 | SNV | Missense_Mutation | c.3614G>A | p.Gly1205Glu | p.G1205E | Q9UGU0 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.946) | TCGA-34-2596-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |