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Gene: MYO18A |
Gene summary for MYO18A |
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Gene information | Species | Human | Gene symbol | MYO18A | Gene ID | 399687 |
Gene name | myosin XVIIIA | |
Gene Alias | MAJN | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q92614 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
399687 | MYO18A | NAFLD1 | Human | Liver | NAFLD | 1.27e-09 | 6.05e-01 | -0.04 |
399687 | MYO18A | S41 | Human | Liver | Cirrhotic | 2.78e-03 | 3.37e-01 | -0.0343 |
399687 | MYO18A | HCC1_Meng | Human | Liver | HCC | 3.09e-10 | -4.09e-02 | 0.0246 |
399687 | MYO18A | HCC2 | Human | Liver | HCC | 1.88e-08 | 2.94e+00 | 0.5341 |
399687 | MYO18A | S014 | Human | Liver | HCC | 3.06e-04 | 2.87e-01 | 0.2254 |
399687 | MYO18A | S015 | Human | Liver | HCC | 6.99e-03 | 2.20e-01 | 0.2375 |
399687 | MYO18A | S016 | Human | Liver | HCC | 2.32e-04 | 2.28e-01 | 0.2243 |
399687 | MYO18A | S027 | Human | Liver | HCC | 2.51e-02 | 4.81e-01 | 0.2446 |
399687 | MYO18A | S028 | Human | Liver | HCC | 2.75e-19 | 6.41e-01 | 0.2503 |
399687 | MYO18A | S029 | Human | Liver | HCC | 4.66e-16 | 8.34e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00481936 | Liver | NAFLD | Golgi vesicle transport | 66/1882 | 296/18723 | 3.66e-10 | 9.30e-08 | 66 |
GO:00071636 | Liver | NAFLD | establishment or maintenance of cell polarity | 46/1882 | 218/18723 | 8.80e-07 | 4.60e-05 | 46 |
GO:00300106 | Liver | NAFLD | establishment of cell polarity | 34/1882 | 143/18723 | 1.41e-06 | 6.56e-05 | 34 |
GO:0007030 | Liver | NAFLD | Golgi organization | 36/1882 | 157/18723 | 1.76e-06 | 7.68e-05 | 36 |
GO:00310326 | Liver | NAFLD | actomyosin structure organization | 41/1882 | 196/18723 | 4.26e-06 | 1.66e-04 | 41 |
GO:00512227 | Liver | NAFLD | positive regulation of protein transport | 55/1882 | 303/18723 | 1.07e-05 | 3.35e-04 | 55 |
GO:19049517 | Liver | NAFLD | positive regulation of establishment of protein localization | 55/1882 | 319/18723 | 4.79e-05 | 1.14e-03 | 55 |
GO:00069007 | Liver | NAFLD | vesicle budding from membrane | 17/1882 | 61/18723 | 7.31e-05 | 1.52e-03 | 17 |
GO:00160505 | Liver | NAFLD | vesicle organization | 50/1882 | 300/18723 | 2.42e-04 | 4.06e-03 | 50 |
GO:0090161 | Liver | NAFLD | Golgi ribbon formation | 6/1882 | 13/18723 | 9.41e-04 | 1.12e-02 | 6 |
GO:0050764 | Liver | NAFLD | regulation of phagocytosis | 19/1882 | 95/18723 | 2.61e-03 | 2.41e-02 | 19 |
GO:00355926 | Liver | NAFLD | establishment of protein localization to extracellular region | 52/1882 | 360/18723 | 4.80e-03 | 3.81e-02 | 52 |
GO:00507147 | Liver | NAFLD | positive regulation of protein secretion | 24/1882 | 137/18723 | 4.89e-03 | 3.85e-02 | 24 |
GO:0050766 | Liver | NAFLD | positive regulation of phagocytosis | 14/1882 | 66/18723 | 5.28e-03 | 4.08e-02 | 14 |
GO:00093066 | Liver | NAFLD | protein secretion | 51/1882 | 359/18723 | 7.17e-03 | 4.96e-02 | 51 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
GO:001605011 | Liver | Cirrhotic | vesicle organization | 133/4634 | 300/18723 | 7.35e-14 | 6.41e-12 | 133 |
GO:000690012 | Liver | Cirrhotic | vesicle budding from membrane | 41/4634 | 61/18723 | 3.12e-12 | 2.25e-10 | 41 |
GO:190495112 | Liver | Cirrhotic | positive regulation of establishment of protein localization | 135/4634 | 319/18723 | 3.20e-12 | 2.28e-10 | 135 |
GO:005122212 | Liver | Cirrhotic | positive regulation of protein transport | 126/4634 | 303/18723 | 6.85e-11 | 3.77e-09 | 126 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYO18A | SNV | Missense_Mutation | c.5954C>A | p.Ser1985Tyr | p.S1985Y | Q92614 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-DQ-5629-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD | |
MYO18A | SNV | Missense_Mutation | rs200860055 | c.4936N>T | p.Arg1646Trp | p.R1646W | Q92614 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MYO18A | SNV | Missense_Mutation | novel | c.2935N>T | p.Gly979Cys | p.G979C | Q92614 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MYO18A | SNV | Missense_Mutation | novel | c.430N>T | p.Arg144Cys | p.R144C | Q92614 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.543) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MYO18A | SNV | Missense_Mutation | c.4537N>G | p.Thr1513Ala | p.T1513A | Q92614 | protein_coding | tolerated(0.58) | benign(0.181) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MYO18A | SNV | Missense_Mutation | c.4883A>C | p.Glu1628Ala | p.E1628A | Q92614 | protein_coding | deleterious(0.01) | benign(0.156) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MYO18A | SNV | Missense_Mutation | c.2968N>A | p.Gly990Ser | p.G990S | Q92614 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYO18A | SNV | Missense_Mutation | c.5667N>C | p.Glu1889Asp | p.E1889D | Q92614 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MYO18A | SNV | Missense_Mutation | c.2327N>T | p.Lys776Met | p.K776M | Q92614 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MYO18A | SNV | Missense_Mutation | rs751612877 | c.911N>A | p.Arg304Gln | p.R304Q | Q92614 | protein_coding | tolerated(0.27) | benign(0.019) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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