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Gene: KIF21A |
Gene summary for KIF21A |
Gene summary. |
Gene information | Species | Human | Gene symbol | KIF21A | Gene ID | 55605 |
Gene name | kinesin family member 21A | |
Gene Alias | CFEOM1 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q7Z4S6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55605 | KIF21A | LZE2T | Human | Esophagus | ESCC | 1.56e-04 | 9.14e-01 | 0.082 |
55605 | KIF21A | LZE4T | Human | Esophagus | ESCC | 1.07e-06 | 3.55e-01 | 0.0811 |
55605 | KIF21A | LZE7T | Human | Esophagus | ESCC | 9.55e-03 | 2.65e-01 | 0.0667 |
55605 | KIF21A | LZE20T | Human | Esophagus | ESCC | 1.21e-03 | 1.86e-01 | 0.0662 |
55605 | KIF21A | LZE22T | Human | Esophagus | ESCC | 1.59e-02 | 2.50e-01 | 0.068 |
55605 | KIF21A | LZE24T | Human | Esophagus | ESCC | 2.30e-09 | 4.48e-01 | 0.0596 |
55605 | KIF21A | P1T-E | Human | Esophagus | ESCC | 8.99e-13 | 4.40e-01 | 0.0875 |
55605 | KIF21A | P2T-E | Human | Esophagus | ESCC | 6.18e-29 | 6.23e-01 | 0.1177 |
55605 | KIF21A | P4T-E | Human | Esophagus | ESCC | 3.37e-12 | 5.29e-01 | 0.1323 |
55605 | KIF21A | P5T-E | Human | Esophagus | ESCC | 2.48e-20 | 5.05e-01 | 0.1327 |
55605 | KIF21A | P8T-E | Human | Esophagus | ESCC | 2.73e-12 | 2.85e-01 | 0.0889 |
55605 | KIF21A | P9T-E | Human | Esophagus | ESCC | 4.15e-17 | 5.41e-01 | 0.1131 |
55605 | KIF21A | P10T-E | Human | Esophagus | ESCC | 2.45e-34 | 7.25e-01 | 0.116 |
55605 | KIF21A | P11T-E | Human | Esophagus | ESCC | 1.10e-05 | 4.64e-01 | 0.1426 |
55605 | KIF21A | P12T-E | Human | Esophagus | ESCC | 2.00e-89 | 1.82e+00 | 0.1122 |
55605 | KIF21A | P15T-E | Human | Esophagus | ESCC | 7.49e-21 | 6.55e-01 | 0.1149 |
55605 | KIF21A | P16T-E | Human | Esophagus | ESCC | 8.90e-08 | 1.50e-01 | 0.1153 |
55605 | KIF21A | P20T-E | Human | Esophagus | ESCC | 7.20e-28 | 6.95e-01 | 0.1124 |
55605 | KIF21A | P21T-E | Human | Esophagus | ESCC | 1.06e-09 | 2.09e-01 | 0.1617 |
55605 | KIF21A | P22T-E | Human | Esophagus | ESCC | 2.48e-15 | 2.82e-01 | 0.1236 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa048145 | Oral cavity | NEOLP | Motor proteins | 37/1112 | 193/8465 | 1.06e-02 | 3.54e-02 | 2.22e-02 | 37 |
hsa0481412 | Oral cavity | NEOLP | Motor proteins | 37/1112 | 193/8465 | 1.06e-02 | 3.54e-02 | 2.22e-02 | 37 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF21A | SNV | Missense_Mutation | c.2504G>C | p.Arg835Pro | p.R835P | Q7Z4S6 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
KIF21A | SNV | Missense_Mutation | c.2503C>T | p.Arg835Trp | p.R835W | Q7Z4S6 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
KIF21A | SNV | Missense_Mutation | c.347N>T | p.Arg116Leu | p.R116L | Q7Z4S6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIF21A | SNV | Missense_Mutation | rs778178203 | c.1397C>T | p.Ala466Val | p.A466V | Q7Z4S6 | protein_coding | tolerated(0.11) | benign(0.293) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KIF21A | SNV | Missense_Mutation | novel | c.4913A>T | p.His1638Leu | p.H1638L | Q7Z4S6 | protein_coding | tolerated(0.13) | benign(0.012) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
KIF21A | SNV | Missense_Mutation | c.1729N>T | p.Asp577Tyr | p.D577Y | Q7Z4S6 | protein_coding | deleterious(0.01) | benign(0.235) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIF21A | SNV | Missense_Mutation | novel | c.1060N>C | p.Asp354His | p.D354H | Q7Z4S6 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-MP-A4T4-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF21A | SNV | Missense_Mutation | c.2225N>T | p.His742Leu | p.H742L | Q7Z4S6 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-21-5784-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIF21A | SNV | Missense_Mutation | c.1116N>C | p.Lys372Asn | p.K372N | Q7Z4S6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-33-6737-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | PD | |
KIF21A | SNV | Missense_Mutation | c.4900G>C | p.Val1634Leu | p.V1634L | Q7Z4S6 | protein_coding | deleterious(0) | benign(0.035) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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