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Gene: DSEL |
Gene summary for DSEL |
Gene summary. |
Gene information | Species | Human | Gene symbol | DSEL | Gene ID | 92126 |
Gene name | dermatan sulfate epimerase like | |
Gene Alias | C18orf4 | |
Cytomap | 18q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006022 | UniProtAcc | Q8IZU8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92126 | DSEL | P3 | Human | Breast | IDC | 8.22e-10 | 7.51e-01 | 0.1542 |
92126 | DSEL | DCIS2 | Human | Breast | DCIS | 2.87e-22 | 1.61e-01 | 0.0085 |
92126 | DSEL | LZE7T | Human | Esophagus | ESCC | 7.63e-03 | 1.41e-01 | 0.0667 |
92126 | DSEL | P2T-E | Human | Esophagus | ESCC | 6.34e-06 | 1.46e-01 | 0.1177 |
92126 | DSEL | P4T-E | Human | Esophagus | ESCC | 4.08e-11 | 3.43e-01 | 0.1323 |
92126 | DSEL | P5T-E | Human | Esophagus | ESCC | 9.42e-11 | 3.16e-01 | 0.1327 |
92126 | DSEL | P8T-E | Human | Esophagus | ESCC | 3.89e-08 | 1.37e-01 | 0.0889 |
92126 | DSEL | P11T-E | Human | Esophagus | ESCC | 3.37e-14 | 7.72e-01 | 0.1426 |
92126 | DSEL | P16T-E | Human | Esophagus | ESCC | 8.75e-05 | 2.00e-01 | 0.1153 |
92126 | DSEL | P19T-E | Human | Esophagus | ESCC | 3.39e-06 | 2.59e-01 | 0.1662 |
92126 | DSEL | P20T-E | Human | Esophagus | ESCC | 2.82e-04 | 1.29e-01 | 0.1124 |
92126 | DSEL | P22T-E | Human | Esophagus | ESCC | 1.35e-20 | 5.29e-01 | 0.1236 |
92126 | DSEL | P23T-E | Human | Esophagus | ESCC | 2.16e-02 | 4.09e-02 | 0.108 |
92126 | DSEL | P26T-E | Human | Esophagus | ESCC | 1.61e-03 | 7.61e-02 | 0.1276 |
92126 | DSEL | P28T-E | Human | Esophagus | ESCC | 9.10e-03 | 4.13e-02 | 0.1149 |
92126 | DSEL | P30T-E | Human | Esophagus | ESCC | 7.16e-10 | 3.49e-01 | 0.137 |
92126 | DSEL | P32T-E | Human | Esophagus | ESCC | 3.29e-22 | 6.23e-01 | 0.1666 |
92126 | DSEL | P36T-E | Human | Esophagus | ESCC | 1.12e-07 | 4.18e-01 | 0.1187 |
92126 | DSEL | P37T-E | Human | Esophagus | ESCC | 2.13e-25 | 6.12e-01 | 0.1371 |
92126 | DSEL | P39T-E | Human | Esophagus | ESCC | 2.05e-06 | 1.29e-01 | 0.0894 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:0006029 | Esophagus | ESCC | proteoglycan metabolic process | 48/8552 | 79/18723 | 4.93e-03 | 1.89e-02 | 48 |
GO:0030166 | Esophagus | ESCC | proteoglycan biosynthetic process | 35/8552 | 56/18723 | 8.30e-03 | 2.94e-02 | 35 |
GO:0006024 | Esophagus | ESCC | glycosaminoglycan biosynthetic process | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
GO:0006023 | Esophagus | ESCC | aminoglycan biosynthetic process | 47/8552 | 79/18723 | 9.29e-03 | 3.23e-02 | 47 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:00442721 | Liver | Cirrhotic | sulfur compound biosynthetic process | 58/4634 | 148/18723 | 6.93e-05 | 7.83e-04 | 58 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:00442722 | Liver | HCC | sulfur compound biosynthetic process | 95/7958 | 148/18723 | 7.89e-08 | 1.58e-06 | 95 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
GO:004427212 | Thyroid | ATC | sulfur compound biosynthetic process | 66/6293 | 148/18723 | 3.43e-03 | 1.53e-02 | 66 |
GO:000910011 | Thyroid | ATC | glycoprotein metabolic process | 153/6293 | 387/18723 | 7.90e-03 | 3.06e-02 | 153 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DSEL | SNV | Missense_Mutation | c.1894N>C | p.Gly632Arg | p.G632R | Q8IZU8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-73-4668-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | pemetrexed | PD | |
DSEL | SNV | Missense_Mutation | c.1512N>T | p.Leu504Phe | p.L504F | Q8IZU8 | protein_coding | tolerated(0.11) | benign(0.024) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD | |
DSEL | SNV | Missense_Mutation | c.3213G>C | p.Leu1071Phe | p.L1071F | Q8IZU8 | protein_coding | deleterious(0.03) | possibly_damaging(0.732) | TCGA-J2-8194-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
DSEL | SNV | Missense_Mutation | novel | c.3431N>T | p.Pro1144Leu | p.P1144L | Q8IZU8 | protein_coding | deleterious(0) | possibly_damaging(0.736) | TCGA-J2-A4AD-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DSEL | SNV | Missense_Mutation | c.46N>T | p.Thr16Ser | p.T16S | Q8IZU8 | protein_coding | deleterious_low_confidence(0.05) | benign(0.133) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
DSEL | SNV | Missense_Mutation | novel | c.1958N>T | p.Ser653Ile | p.S653I | Q8IZU8 | protein_coding | deleterious(0) | possibly_damaging(0.53) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DSEL | SNV | Missense_Mutation | novel | c.1391N>G | p.Tyr464Cys | p.Y464C | Q8IZU8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DSEL | SNV | Missense_Mutation | rs765642118 | c.78G>A | p.Met26Ile | p.M26I | Q8IZU8 | protein_coding | tolerated_low_confidence(0.52) | benign(0) | TCGA-21-1075-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DSEL | SNV | Missense_Mutation | novel | c.3076N>C | p.Phe1026Leu | p.F1026L | Q8IZU8 | protein_coding | tolerated(0.99) | probably_damaging(0.99) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
DSEL | SNV | Missense_Mutation | c.2300N>C | p.Lys767Thr | p.K767T | Q8IZU8 | protein_coding | tolerated(0.06) | benign(0.1) | TCGA-22-5482-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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